Protein Alignment Med and Dad

DIOPT Version :9

• Sequence 1: NP_524610.1
• Gene: Med / 43725
• FlyBaseID: FBgn0011655
• Length: 771
• Species: Drosophila melanogaster
• Sequence 2: NP_001369021.1
• Gene: Dad / 42059
• FlyBaseID: FBgn0020493
• Length: 665
• Species: Drosophila melanogaster
• Alignment Length: 688
• Identity: 146/688 - (21%)
• Similarity: 195/688 - (28%)
• Gaps: 289/688 - (42%)

  Fly   251 PQDGVAGSRGSWMVPP--PPRLGQPPQQQQQQPQQ------------------QTPQPTQ----- 290
            |.:||:.:      ||  |||  .||...:.:|.|                  |||.|..
  Fly    19 PSNGVSAA------PPAQPPR--PPPPPHRPRPHQCTPSFGYSCNEEDSLAMRQTPLPPYSSIAC 75

  Fly   291 -------------QQQAQSQAAAHSLPVPHGMPGMPGPMNPGPVMAPPPPPQQAQNPQGNGVHHT 342
                         |..:.||...|:....|....:|..|:     ..||||....
  Fly    76 GMDCSSSNSSSCGQSLSLSQGQGHNNNNSHPYRRLPNHMD-----VLPPPPSACD---------- 125

  Fly   343 QANSPTDPASALAMQQQQQQQQQQQQQQQQQQQQSGGVPNGSVNAGGGAAAGGQYYGQPPPV--- 404
              ...|.|..:.|..............|.:...|                      ||..||
  Fly   126 --RCCTAPGYSCASSCDDMLIDGSDLDQDRSPDQ----------------------GQVQPVDRR 166

  Fly   405 --------SQMQGAGGGGTSVAPSVHAQQNGYVSQPGSAGSAPVGGGGVFGTAQPTPQQPQ---- 457
                    :..:...||.|.             |..||..:.||....  .||.|...|.|
  Fly   167 MISATTFTTMFRKCCGGATE-------------STSGSTLTIPVSTSR--ATAHPPQTQAQNGKR 216

  Fly   458 ----------------------------QPPTGVQANTGSAGAQAGAGGGAAGTWTGPNTLTY-- 492
                                        .|||..|.:...           ..|.|.|   ||
  Fly   217 FREDFEALMKQLKRKQRNELLLAVKSRLDPPTKTQRDVVE-----------PTTTTAP---TYLQ 267

  Fly   493 -------TQSMQPPDPRSLPGGFWNSSLSGD---------------------------LGSPQ-- 521
                   ||::..|...:....||....:..                           |..|:
  Fly   268 CILIPCKTQTVWEPHVTASRLFFWRELWNAKELKRLPTCPAARDCIYMCCNPLHWFRILHQPETE 332

  Fly   522 -QTPPQQQ---------------QQQQQPRLLSR-----------QPPPEY-------------- 545
             .|||.|:               |...:...||.           ..|..|
  Fly   333 SPTPPYQRSKMLRLKDADFEEDSQNDAKSAALSTWSAESTSISNIYKPALYESVTTDGKDHNINS 397

  Fly   546 --WCSIAYFELDTQVGETFKVPSAKPNVIIDGYVDPSGGNRFCLGAL----SNVHRTEQSERARL 604
              ||.|||:|:..:|||.|...:...|:..||.| .|..:..||..|    :.:|..  ..:||.
  Fly   398 QVWCQIAYWEMAHRVGEFFHAKTNAVNIYTDGIV-ASEVDSMCLRDLTPAGNQIHSV--VPKARH 459

  Fly   605 HIGKGVQLDLRGEGDVWLRCLSDNSVFVQSYYLDREAGRTPGDAVHKIYPAACIKVFDLRQCHQQ 669
            .:|.||.|.|. .||||:....:.::||.|..|....     |.|.|:.|..|:|.|:
  Fly   460 TVGLGVTLSLE-NGDVWIYNRGNTTIFVDSPTLSENL-----DRVCKVMPGYCLKAFE------- 511

  Fly   670 MHSLATNAQAAAAAQAAAVAGVANQQMGGGGRSMTAAAGIGVDDLRRLCILRLSFVKGWGPDYPR 734
                 ||     .|:..::....:..||            .||...    :::||.||||.||.|
  Fly   512 -----TN-----RAELLSMRDHGHHPMG------------PVDYFS----IKISFGKGWGRDYKR 550

  Fly   735 QSIKETPCWIEVHL-HRALQLLDEVLHAMPIDGPRAAA 771
            |.|...|||:|||. |...|.|.....|    ||.:|:
  Fly   551 QDIMGCPCWLEVHFSHLRXQYLMLARSA----GPHSAS 584

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Med	NP_524610.1	MH1_SMAD_4	42..166	CDD:199816
		MH2_SMAD_4	543..760	CDD:199823	69/237 (29%)
Dad	NP_001369021.1	MH1_SMAD_6_7	197..329	CDD:199813	21/147 (14%)
		MH2_I-SMAD	400..565	CDD:199821	65/206 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45444267
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3701
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR13703
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840