Protein Alignment Med and SMAD9

DIOPT Version :9

• Sequence 1: NP_524610.1
• Gene: Med / 43725
• FlyBaseID: FBgn0011655
• Length: 771
• Species: Drosophila melanogaster
• Sequence 2: XP_006719890.1
• Gene: SMAD9 / 4093
• HGNCID: 6774
• Length: 479
• Species: Homo sapiens
• Alignment Length: 695
• Identity: 189/695 - (27%)
• Similarity: 250/695 - (35%)
• Gaps: 308/695 - (44%)

  Fly    48 VHSLMCHRQGGESEGFAKRAIESLVKKLKEKRDELDSLITAITTNGAHPSKCVTIQRTLDGRLQV 112
            |..|:..:||.|.|.:|::|::|||||||:|:..:|.|..|::..| .|||||||.|:|||||||
Human    18 VKRLLGWKQGDEEEKWAEKAVDSLVKKLKKKKGAMDELERALSCPG-QPSKCVTIPRSLDGRLQV 81

  Fly   113 AGRKGFPHVIYARIWRWPDLHK-NELKHVKYCAFAFDLKCDSVCVNPYHYERVVSPGIDLSGLSL 176
            :.|||.|||||.|:||||||.. :|||.::.|.|.|..|...||:|||||.||.:|.:
Human    82 SHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSKQKEVCINPYHYRRVETPVL------- 139

  Fly   177 QSGPSRLVKDEYSAGPLVGSMDIDGNDIGTIQHHPTQMVGPGGYGYPQGPSEYVGDANPMSAMFP 241
               |..||.                      :|                 |||    ||..::..
Human   140 ---PPVLVP----------------------RH-----------------SEY----NPQLSLLA 158

  Fly   242 TGRTIPKIEPQDGVAGSRGSWMVPPPPRLGQPPQQQQQQPQQQTPQPTQQQQAQSQAAAHSLP-V 305
            ..|:                                                    |:.||.| :
Human   159 KFRS----------------------------------------------------ASLHSEPLM 171

  Fly   306 PHGMPGMPGPMNPGPVMAPPPPPQQAQNPQGNGVHHTQANSPTDPASALAMQQQQQQQQQQQQQQ 370
            ||... .|......|..|.||.|..|
Human   172 PHNAT-YPDSFQQPPCSALPPSPSHA--------------------------------------- 196

  Fly   371 QQQQQQSGGVPNGSVNAGGGAAAGGQYYGQPPPVSQMQGAGGGGTSVAPSVHAQQNGYVSQPGSA 435
                                       :.|.|..:                     .|...|||.
Human   197 ---------------------------FSQSPCTA---------------------SYPHSPGSP 213

  Fly   436 GSAPVGGGGVFGTAQPTPQQPQQ-----PPTGVQANTGSAGAQAGAGGGAAGTWTGPNTLTYTQS 495
            ..               |:.|.|     ||....|...|.                      |||
Human   214 SE---------------PESPYQHSVDTPPLPYHATEASE----------------------TQS 241

  Fly   496 MQPPDPR-------SLPGGFWNSSLSGDLGSPQQTPPQQQQQQQQPRLLSRQPPPEYWCSIAYFE 553
            .||.|..       |:|.|.:.              |...::            |::|||:||:|
Human   242 GQPVDATADRHVVLSIPNGDFR--------------PVCYEE------------PQHWCSVAYYE 280

  Fly   554 LDTQVGETFKVPSAKPNVIIDGYVDPSGG-NRFCLGALSNVHRTEQSERARLHIGKGVQLDLRGE 617
            |:.:|||||:..|.  :|:|||:.|||.. ||||||.||||:|....|..|.||||||.|...|
Human   281 LNNRVGETFQASSR--SVLIDGFTDPSNNRNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVG- 342

  Fly   618 GDVWLRCLSDNSVFVQSYYLDREAGRTPGDAVHKIYPAAC-IKVFDLRQCHQQMHSLATNAQAAA 681
            |:|:..|:||:|:||||...:.:.|..|. .|.|| |:.| :|||              |.|..|
Human   343 GEVYAECVSDSSIFVQSRNCNYQHGFHPA-TVCKI-PSGCSLKVF--------------NNQLFA 391

  Fly   682 AAQAAAVAGVANQQMGGGGRSMTAAAGIGVDDLRRLCILRLSFVK 726
            ...|.:|         ..|..:       |.:|.::|.:|:||||
Human   392 QLLAQSV---------HHGFEV-------VYELTKMCTIRMSFVK 420

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Med	NP_524610.1	MH1_SMAD_4	42..166	CDD:199816	66/118 (56%)
		MH2_SMAD_4	543..760	CDD:199823	76/186 (41%)
SMAD9	XP_006719890.1	MH1_SMAD_1_5_9	13..136	CDD:199814	66/118 (56%)
		MH2	267..>420	CDD:294046	74/199 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3701
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810