Protein Alignment Med and SMAD7

DIOPT Version :9

• Sequence 1: NP_524610.1
• Gene: Med / 43725
• FlyBaseID: FBgn0011655
• Length: 771
• Species: Drosophila melanogaster
• Sequence 2: NP_005895.1
• Gene: SMAD7 / 4092
• HGNCID: 6773
• Length: 426
• Species: Homo sapiens
• Alignment Length: 502
• Identity: 119/502 - (23%)
• Similarity: 153/502 - (30%)
• Gaps: 235/502 - (46%)

  Fly   381 PNG--SVNAGGGAAAGGQYYGQPPPVSQMQGAGGGGTSVAPSVHAQQNGYVSQPGSAGSAPVGGG 443
            |.|  .....||...||:..|:....|:..||||||                 ||.||.. :|..
Human    19 PGGEDEEEGAGGGGGGGELRGEGATDSRAHGAGGGG-----------------PGRAGCC-LGKA 65

  Fly   444 --GVFGTAQPTPQQPQQPPTGVQANTGSAGAQAGAGGGA-------------------------- 480
              |..|...|.|     |..|           |||.|||
Human    66 VRGAKGHHHPHP-----PAAG-----------AGAAGGAEADLKALTHSVLKKLKERQLELLLQA 114

  Fly   481 ----AGTWT-------------GPNTLTYTQSMQPPDPRSLPGGF-----WNSSLSGDLGSPQQT 523
                .||.|             ||......|..|||...|||...     |
Human   115 VESRGGTRTACLLLPGRLDCRLGPGAPAGAQPAQPPSSYSLPLLLCKVFRW-------------- 165

  Fly   524 PPQQQQQQQQPRL--------------------LSR-----QPPPEY------------------ 545
             |..:...:..||                    |||     .|||.|
Human   166 -PDLRHSSEVKRLCCCESYGKINPELVCCNPHHLSRLCELESPPPPYSRYPMDFLKPTADCPDAV 229

  Fly   546 -------------------------------WCSIAYFELDTQVGETFKV--PSAKPNVIIDGYV 577
                                           ||.:||:|..|:||..:.|  ||      :|.:.
Human   230 PSSAETGGTNYLAPGGLSDSQLLLEPGDRSHWCVVAYWEEKTRVGRLYCVQEPS------LDIFY 288

  Fly   578 DPSGGNRFCLGALSNVHRTEQSERARLHIGKGVQLDLRGEGDVWLRCLSDNSVFVQSYYLDREAG 642
            |...||.||||.|::.::::..::.|..||.|:||....:| ||:...|...:|::|..||....
Human   289 DLPQGNGFCLGQLNSDNKSQLVQKVRSKIGCGIQLTREVDG-VWVYNRSSYPIFIKSATLDNPDS 352

  Fly   643 RTPGDAVHKIYPAACIKVFDLRQC--------HQQMHSLATNAQAAAAAQAAAVAGVANQQMGGG 699
            ||.  .|||::|...||.||..:.        |:.|                       ||...|
Human   353 RTL--LVHKVFPGFSIKAFDYEKAYSLQRPNDHEFM-----------------------QQPWTG 392

  Fly   700 GRSMTAAAGIGVDDLRRLCILRLSFVKGWGPDYPRQSIKETPCWIEV 746
                              ..:::|||||||..|.||.|...|||:||
Human   393 ------------------FTVQISFVKGWGQCYTRQFISSCPCWLEV 421

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Med	NP_524610.1	MH1_SMAD_4	42..166	CDD:199816
		MH2_SMAD_4	543..760	CDD:199823	67/263 (25%)
SMAD7	NP_005895.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	13..55		14/52 (27%)
		MH1_SMAD_7	60..205	CDD:199818	32/176 (18%)
		Important for interaction with SMURF2	208..217		3/8 (38%)
		PY-motif	208..211		2/2 (100%)
		MH2_SMAD_7	254..424	CDD:199825	65/218 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3701
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810