Protein Alignment Med and SMAD6

DIOPT Version :10

• Sequence 1: NP_524610.1
• Gene: Med / 43725
• FlyBaseID: FBgn0288966
• Length: 771
• Species: Drosophila melanogaster
• Sequence 2: NP_005576.3
• Gene: SMAD6 / 4091
• HGNCID: 6772
• Length: 496
• Species: Homo sapiens
• Alignment Length: 782
• Identity: 144/782 - (18%)
• Similarity: 205/782 - (26%)
• Gaps: 410/782 - (52%)

  Fly     3 GGSGACPPAHMY--GAVAPQDIIVRDMVQMPPPPSNAPTSADACLSIVHSLMCHRQ--------- 56
            ||    ||..|.  ||.|...::  |:.: |..|...|.|  .|.::...|...|.
Human    87 GG----PPRPMSEPGAGAGSSLL--DVAE-PGGPGWLPES--DCETVTCCLFSERDAAGAPRDAS 142

  Fly    57 ------------GGES----------EGFAKRAIESLVKKLKEKRDELDSLITAITTNGAHPSKC 99
                        ||.|          |...|....||:|:|||:  .||:|:.|:.:.|..|..|
Human   143 DPLAGAALEPAGGGRSREARSRLLLLEQELKTVTYSLLKRLKER--SLDTLLEAVESRGGVPGGC 205

  Fly   100 VTIQRTLDGRLQVAGRKGFPHVIYARIWRWPDL-HKNELKHVKYC-AFAFDLKCDSVCVNPYHYE 162
            |.:.|   ..|::.|:...|.::..|::||||| |..|||.:..| :||......:||.||||:.
Human   206 VLVPR---ADLRLGGQPAPPQLLLGRLFRWPDLQHAVELKPLCGCHSFAAAADGPTVCCNPYHFS 267

  Fly   163 RVVSPGIDLSGLSLQSGPSRLVKDEYSAGPLVGSMDIDGNDIGTIQHHPTQMVGPGGYGYPQGPS 227
            |:..|
Human   268 RLCGP------------------------------------------------------------ 272

  Fly   228 EYVGDANPMSAMFPTGRTIPKIEPQDGVAGSRGSWMVPPPPRLGQPPQQQQQQPQQQTPQPTQQQ 292
                                                                             
Human   273 ----------------------------------------------------------------- 272

  Fly   293 QAQSQAAAHSLPVPHGMPGMPGPMNPGPVMAPPPPPQQAQNPQGNGVHHTQANSPTDPASALAMQ 357
                                         .:||||..:.              ||.|....|.:.
Human   273 -----------------------------ESPPPPYSRL--------------SPRDEYKPLDLS 294

  Fly   358 QQQQQQQQQQQQQQQQQQQSGGVPNGSVNAGGGAAAGGQYYGQPPPVSQMQGAGGGGTSVAPSVH 422
            .
Human   295 D---------------------------------------------------------------- 295

  Fly   423 AQQNGYVSQPGSAGSAPVGGGGVFGTAQPTPQQPQQPPTGVQANTGSAGAQAGAGGGAAGTWTGP 487
                                                                             
Human   296 ----------------------------------------------------------------- 295

  Fly   488 NTLTYTQSMQPPDPRSLPGGFWNSSLSGDLGSPQQTPPQQQQQQQQPRLLSRQPPPEYWCSIAYF 552
            :||:||::.......:.||.|.::|:|.|                       ...|.:|||:||:
Human   296 STLSYTETEATNSLITAPGEFSDASMSPD-----------------------ATKPSHWCSVAYW 337

  Fly   553 ELDTQVGETFKVPSAKPNVIIDGYVDPSGGNRFCLGALSNVHRTEQSERARLHIGKGVQLDLRGE 617
            |..|:||..:.|.....::    :.|...|:.||||.|:...|:|...|.|..||.|:.|....:
Human   338 EHRTRVGRLYAVYDQAVSI----FYDLPQGSGFCLGQLNLEQRSESVRRTRSKIGFGILLSKEPD 398

  Fly   618 GDVWLRCLSDNSVFVQSYYLDREAGRTPGDAVHKIYPAACIKVFDLRQCHQQMHSLATNAQAAAA 682
            | ||.....::.:||.|..||...||..  .|.|:.|...|||||..:         :..|.|..
Human   399 G-VWAYNRGEHPIFVNSPTLDAPGGRAL--VVRKVPPGYSIKVFDFER---------SGLQHAPE 451

  Fly   683 AQAAAVAGVANQQMGGGGRSMTAAAGIGVDDLRRLCILRLSFVKGWGPDYPRQSIKETPCWIEVH 747
            ..||......|.                         :|:||.|||||.|.||.|...|||:|:.
Human   452 PDAADGPYDPNS-------------------------VRISFAKGWGPCYSRQFITSCPCWLEIL 491

  Fly   748 LH 749
            |:
Human   492 LN 493

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Med	NP_524610.1	MH1_SMAD_4	42..166	CDD:199816	46/156 (29%)
		MH2_SMAD_4	543..760	CDD:199823	66/207 (32%)
SMAD6	NP_005576.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..116		11/35 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	136..156		0/19 (0%)
		MH1_SMAD_6	160..273	CDD:199817	41/271 (15%)
		MH2_SMAD_6	322..494	CDD:199824	68/236 (29%)