| Sequence 1: | NP_524610.1 | Gene: | Med / 43725 | FlyBaseID: | FBgn0011655 | Length: | 771 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_005350.1 | Gene: | SMAD4 / 4089 | HGNCID: | 6770 | Length: | 552 | Species: | Homo sapiens |
| Alignment Length: | 756 | Identity: | 380/756 - (50%) |
|---|---|---|---|
| Similarity: | 420/756 - (55%) | Gaps: | 235/756 - (31%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 35 SNAPTSADACLSIVHSLMCHRQGGESEGFAKRAIESLVKKLKEKRDELDSLITAITTNGAHPSKC 99
Fly 100 VTIQRTLDGRLQVAGRKGFPHVIYARIWRWPDLHKNELKHVKYCAFAFDLKCDSVCVNPYHYERV 164
Fly 165 VSPGIDLSGLSLQSG--PSRLVKDEY----SAGPLVGSMDIDGNDIGTIQHHPTQMVGPGGYGYP 223
Fly 224 Q--GPSEYVGDANPMSAMFPTGRTIPKIEPQDGVAGSRGSWMVPPPPRLGQPPQQQQQQPQQQTP 286
Fly 287 QPTQQQQAQSQAAAHSLPVPHGMPGMPGPMNPGPVMAPPPPPQQAQNPQGNGVHHTQANSPTDPA 351
Fly 352 SALAMQQQQQQQQQQQQQQQQQQQQSGGVPNGSVNAGGGAAAGGQYYGQPPPVSQMQGAGGGGTS 416
Fly 417 VAPSVHAQQNGYVSQPGSAGSAPVGGGGVFGTAQPTPQQPQQPPTGVQANTGSAGAQAGAGGGAA 481
Fly 482 GTWTGPNTLTYTQSM----------QPPDPRSLPGGFWNSSLSGDLGSPQQTPPQQQQQQQQPRL 536
Fly 537 LSRQPPPEYWCSIAYFELDTQVGETFKVPSAKPNVIIDGYVDPSGGNRFCLGALSNVHRTEQSER 601
Fly 602 ARLHIGKGVQLDLRGEGDVWLRCLSDNSVFVQSYYLDREAGRTPGDAVHKIYPAACIKVFDLRQC 666
Fly 667 HQQMHSLATNAQAAAAAQAAAVAG-VANQQMGGG---GRSMTAAAGIGVDDLRRLCILRLSFVKG 727
Fly 728 WGPDYPRQSIKETPCWIEVHLHRALQLLDEVLHAMPIDGPR 768 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| Med | NP_524610.1 | MH1_SMAD_4 | 42..166 | CDD:199816 | 118/123 (96%) |
| MH2_SMAD_4 | 543..760 | CDD:199823 | 177/220 (80%) | ||
| SMAD4 | NP_005350.1 | Mediates interaction with ZBTB7A. /evidence=ECO:0000269|PubMed:25514493 | 1..322 | 198/527 (38%) | |
| MH1_SMAD_4 | 14..138 | CDD:199816 | 118/123 (96%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 168..194 | 9/28 (32%) | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 236..256 | 9/35 (26%) | |||
| SAD | 275..320 | 13/61 (21%) | |||
| MH2_SMAD_4 | 320..541 | CDD:199823 | 177/220 (80%) |
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 1 | 1.000 | 344 | 1.000 | Domainoid score | I1056 |
| eggNOG | 1 | 0.900 | - | - | E1_KOG3701 | |
| Hieranoid | 1 | 1.000 | - | - | ||
| Homologene | 1 | 1.000 | - | - | H31310 | |
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 1 | 1.010 | - | - | QHG48996 | |
| OrthoDB | 1 | 1.010 | - | - | D386709at33208 | |
| OrthoFinder | 1 | 1.000 | - | - | FOG0004851 | |
| OrthoInspector | 1 | 1.000 | - | - | oto90824 | |
| orthoMCL | 1 | 0.900 | - | - | OOG6_105347 | |
| Panther | 1 | 1.100 | - | - | LDO | PTHR13703 |
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 1 | 1.030 | - | avgDist | Average_Evolutionary_Distance | R5008 |
| SonicParanoid | 1 | 1.000 | - | - | X3979 | |
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 13 | 12.860 | |||||