Protein Alignment Med and SMAD3

DIOPT Version :10

• Sequence 1: NP_524610.1
• Gene: Med / 43725
• FlyBaseID: FBgn0288966
• Length: 771
• Species: Drosophila melanogaster
• Sequence 2: NP_001393940.1
• Gene: SMAD3 / 4088
• HGNCID: 6769
• Length: 462
• Species: Homo sapiens
• Alignment Length: 746
• Identity: 194/746 - (26%)
• Similarity: 263/746 - (35%)
• Gaps: 356/746 - (47%)

  Fly    56 QGGESEGFAKRAIESLVKKLKEKRDELDSLITAITTNGAHPSKCVTIQRTLDGRLQVAGRKGFPH 120
            |.|:.|.:.::|::||||||| |..:||.|..||||...: :||:||.|:|||||||:.|||.||
Human    23 QNGQEEKWCEKAVKSLVKKLK-KTGQLDELEKAITTQNVN-TKCITIPRSLDGRLQVSHRKGLPH 85

  Fly   121 VIYARIWRWPDLHK-NELKHVKYCAFAFDLKCDSVCVNPYHYERVVSPGIDLSGLSLQSGPSRLV 184
            |||.|:|||||||. :||:.::.|.|||::|.|.||||||||:||.:|.:          |..||
Human    86 VIYCRLWRWPDLHSHHELRAMELCEFAFNMKKDEVCVNPYHYQRVETPVL----------PPVLV 140

  Fly   185 KDEYSAGPLVGSMDIDGNDIGTIQHHPTQMVGPGGYGYPQGPSEYVGDANPMSAMFPTGRTIPKI 249
                                      |.....|..:    .|.:....:.|.:..||.|     |
Human   141 --------------------------PRHTEIPAEF----PPLDDYSHSIPENTNFPAG-----I 170

  Fly   250 EPQDGVAGSRGSWMVPPPPRLGQPPQQQQQQPQQQTPQPTQQQQAQSQAAAHSLPVPHGMPGM-P 313
            |||..:..:      |||..|.:..:....|..                  ||:..  |.|.: |
Human   171 EPQSNIPET------PPPGYLSEDGETSDHQMN------------------HSMDA--GSPNLSP 209

  Fly   314 GPMNPGPVMAPPPPPQQAQNPQGNGVHHTQANSPTDPASALAMQQQQQQQQQQQQQQQQQQQQSG 378
            .||:|.
Human   210 NPMSPA----------------------------------------------------------- 215

  Fly   379 GVPNGSVNAGGGAAAGGQYYGQPPPVSQMQGAGGGGTSVAPSVHAQQNGYVSQPGSAGSAPVGGG 443
                                                          .|....||
Human   216 ----------------------------------------------HNNLDLQP----------- 223

  Fly   444 GVFGTAQPTPQQPQQPPTGVQANTGSAGAQAGAGGGAAGTWTGPNTLTYTQSMQPPDPRSLPGGF 508
                                                          :||.:
Human   224 ----------------------------------------------VTYCE-------------- 228

  Fly   509 WNSSLSGDLGSPQQTPPQQQQQQQQPRLLSRQPPPEYWCSIAYFELDTQVGETFKVPSAKPNVII 573
                                              |.:||||:|:||:.:|||||.  :::|::.:
Human   229 ----------------------------------PAFWCSISYYELNQRVGETFH--ASQPSMTV 257

  Fly   574 DGYVDPSGGNRFCLGALSNVHRTEQSERARLHIGKGVQLDLRGEGDVWLRCLSDNSVFVQSYYLD 638
            ||:.|||...|||||.||||:|....|..|.|||:||:|...| |:|:..||||:::||||...:
Human   258 DGFTDPSNSERFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIG-GEVFAECLSDSAIFVQSPNCN 321

  Fly   639 REAGRTPGDAVHKIYP------------------------------------AAC-IKVFDLRQC 666
            :..|..|. .|.||.|                                    |.| :|:|
Human   322 QRYGWHPA-TVCKIPPGKAPLSTPSPYFWKPSLQTSPCSGSRSLWASLPSPLAGCNLKIF----- 380

  Fly   667 HQQMHSLATNAQAAAAAQAAAVAGVANQQMGGGGRSMTAAAGIGVDDLRRLCILRLSFVKGWGPD 731
                     |.|..||..|.:|    ||...            .|..|.|:|.:|:|||||||.:
Human   381 ---------NNQEFAALLAQSV----NQGFE------------AVYQLTRMCTIRMSFVKGWGAE 420

  Fly   732 YPRQSIKETPCWIEVHLHRALQLLDEVLHAM 762
            |.||::..||||||:||:..||.||:||..|
Human   421 YRRQTVTSTPCWIELHLNGPLQWLDKVLTQM 451

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Med	NP_524610.1	MH1_SMAD_4	42..166	CDD:199816	65/110 (59%)
		MH2_SMAD_4	543..760	CDD:199823	94/253 (37%)
SMAD3	NP_001393940.1	MH1_SMAD_2_3	8..132	CDD:199815	65/110 (59%)
		MH2	224..451	CDD:469593	97/308 (31%)