Protein Alignment Med and SMAD3

DIOPT Version :9

• Sequence 1: NP_524610.1
• Gene: Med / 43725
• FlyBaseID: FBgn0011655
• Length: 771
• Species: Drosophila melanogaster
• Sequence 2: NP_005893.1
• Gene: SMAD3 / 4088
• HGNCID: 6769
• Length: 425
• Species: Homo sapiens
• Alignment Length: 709
• Identity: 192/709 - (27%)
• Similarity: 261/709 - (36%)
• Gaps: 319/709 - (44%)

  Fly    56 QGGESEGFAKRAIESLVKKLKEKRDELDSLITAITTNGAHPSKCVTIQRTLDGRLQVAGRKGFPH 120
            |.|:.|.:.::|::||||||| |..:||.|..||||...: :||:||.|:|||||||:.|||.||
Human    23 QNGQEEKWCEKAVKSLVKKLK-KTGQLDELEKAITTQNVN-TKCITIPRSLDGRLQVSHRKGLPH 85

  Fly   121 VIYARIWRWPDLHK-NELKHVKYCAFAFDLKCDSVCVNPYHYERVVSPGIDLSGLSLQSGPSRLV 184
            |||.|:|||||||. :||:.::.|.|||::|.|.||||||||:||.:|.:          |..||
Human    86 VIYCRLWRWPDLHSHHELRAMELCEFAFNMKKDEVCVNPYHYQRVETPVL----------PPVLV 140

  Fly   185 KDEYSAGPLVGSMDIDGNDIGTIQHHPTQMVGPGGYGYPQGPSEYVGDANPMSAMFPTGRTIPKI 249
                                      |.....|..:    .|.:....:.|.:..||.|     |
Human   141 --------------------------PRHTEIPAEF----PPLDDYSHSIPENTNFPAG-----I 170

  Fly   250 EPQDGVAGSRGSWMVPPPPRLGQPPQQQQQQPQQQTPQPTQQQQAQSQAAAHSLPVPHGMPGM-P 313
            |||..:..:      |||..|.:..:....|..                  ||:..  |.|.: |
Human   171 EPQSNIPET------PPPGYLSEDGETSDHQMN------------------HSMDA--GSPNLSP 209

  Fly   314 GPMNPGPVMAPPPPPQQAQNPQGNGVHHTQANSPTDPASALAMQQQQQQQQQQQQQQQQQQQQSG 378
            .||:|.
Human   210 NPMSPA----------------------------------------------------------- 215

  Fly   379 GVPNGSVNAGGGAAAGGQYYGQPPPVSQMQGAGGGGTSVAPSVHAQQNGYVSQPGSAGSAPVGGG 443
                                                          .|....||
Human   216 ----------------------------------------------HNNLDLQP----------- 223

  Fly   444 GVFGTAQPTPQQPQQPPTGVQANTGSAGAQAGAGGGAAGTWTGPNTLTYTQSMQPPDPRSLPGGF 508
                                                          :||.:
Human   224 ----------------------------------------------VTYCE-------------- 228

  Fly   509 WNSSLSGDLGSPQQTPPQQQQQQQQPRLLSRQPPPEYWCSIAYFELDTQVGETFKVPSAKPNVII 573
                                              |.:||||:|:||:.:|||||.  :::|::.:
Human   229 ----------------------------------PAFWCSISYYELNQRVGETFH--ASQPSMTV 257

  Fly   574 DGYVDPSGGNRFCLGALSNVHRTEQSERARLHIGKGVQLDLRGEGDVWLRCLSDNSVFVQSYYLD 638
            ||:.|||...|||||.||||:|....|..|.|||:||:|...| |:|:..||||:::||||...:
Human   258 DGFTDPSNSERFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIG-GEVFAECLSDSAIFVQSPNCN 321

  Fly   639 REAGRTPGDAVHKIYPAACIKVFDLRQCHQQMHSLATNAQAAAAAQAAAVAGVANQQMGGGGRSM 703
            :..|..|. .|.||.|...:|:|              |.|..||..|.:|    ||...
Human   322 QRYGWHPA-TVCKIPPGCNLKIF--------------NNQEFAALLAQSV----NQGFE------ 361

  Fly   704 TAAAGIGVDDLRRLCILRLSFVKGWGPDYPRQSIKETPCWIEVHLHRALQLLDEVLHAM 762
                  .|..|.|:|.:|:|||||||.:|.||::..||||||:||:..||.||:||..|
Human   362 ------AVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQM 414

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Med	NP_524610.1	MH1_SMAD_4	42..166	CDD:199816	65/110 (59%)
		MH2_SMAD_4	543..760	CDD:199823	92/216 (43%)
SMAD3	NP_005893.1	MH1_SMAD_2_3	8..132	CDD:199815	65/110 (59%)
		Linker	137..231		32/364 (9%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	165..208		16/73 (22%)
		MH2_SMAD_2_3	224..414	CDD:199826	95/271 (35%)
		Sufficient for interaction with XPO4. /evidence=ECO:0000269|PubMed:16449645	271..324		26/53 (49%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3701
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810