Protein Alignment Med and SMAD2

DIOPT Version :9

• Sequence 1: NP_524610.1
• Gene: Med / 43725
• FlyBaseID: FBgn0011655
• Length: 771
• Species: Drosophila melanogaster
• Sequence 2: NP_001003652.1
• Gene: SMAD2 / 4087
• HGNCID: 6768
• Length: 467
• Species: Homo sapiens
• Alignment Length: 738
• Identity: 198/738 - (26%)
• Similarity: 262/738 - (35%)
• Gaps: 345/738 - (46%)

  Fly    56 QGGESEGFAKRAIESLVKKLKEKRDELDSLITAITTNGAHPSKCVTI------------------ 102
            |.|:.|.:.::|::||||||| |...||.|..||||...: :|||||
Human    33 QNGQEEKWCEKAVKSLVKKLK-KTGRLDELEKAITTQNCN-TKCVTIPSTCSEIWGLSTPNTIDQ 95

  Fly   103 ------------QRTLDGRLQVAGRKGFPHVIYARIWRWPDLHK-NELKHVKYCAFAFDLKCDSV 154
                        .|:|||||||:.|||.|||||.|:|||||||. :|||.::.|.:||:||.|.|
Human    96 WDTTGLYSFSEQTRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELKAIENCEYAFNLKKDEV 160

  Fly   155 CVNPYHYERVVSPGIDLSGLSLQSGPSRLVKDEYSAGPLVGSMDIDGNDIGTIQHHPTQMVGPGG 219
            |||||||:||.:|.:          |..||.                      :|  |::
Human   161 CVNPYHYQRVETPVL----------PPVLVP----------------------RH--TEI----- 186

  Fly   220 YGYPQGPSEYVGDANPMSAMFPTGRTIPKIEPQDGVAGSRGSWMVPPPPRLGQPPQQQQQQPQQQ 284
                                      :.::.|.|..
Human   187 --------------------------LTELPPLDDY----------------------------- 196

  Fly   285 TPQPTQQQQAQSQAAAHSLPVPHGMPGMPGPMNPGPVMAPPPPPQQAQNPQGNGVHHTQANSPTD 349
                           .||:|.....|.                   ...||.|.:..|
Human   197 ---------------THSIPENTNFPA-------------------GIEPQSNYIPET------- 220

  Fly   350 PASALAMQQQQQQQQQQQQQQQQQQQQSGGVPNGSVNAGGGAAAGGQYYGQPPPVSQMQGAGGGG 414
                                                               |||
Human   221 ---------------------------------------------------PPP----------- 223

  Fly   415 TSVAPSVHAQQNGYVSQPGSAGSAPVGGGGVFGTAQPTPQQPQQPPTGVQANTGSAGAQAGAGGG 479
                        ||:|:.|                :.:.||
Human   224 ------------GYISEDG----------------ETSDQQ------------------------ 236

  Fly   480 AAGTWTGPNTLTYTQSMQPPDPRSLPGGFWNSSLSGDLGSPQQTPPQQQQQQQQPRLLSRQPPPE 544
                        ..|||....|..|              ||....|.......||...|.   |.
Human   237 ------------LNQSMDTGSPAEL--------------SPTTLSPVNHSLDLQPVTYSE---PA 272

  Fly   545 YWCSIAYFELDTQVGETFKVPSAKPNVIIDGYVDPSGGNRFCLGALSNVHRTEQSERARLHIGKG 609
            :||||||:||:.:|||||.  :::|::.:||:.|||...|||||.||||:|....|..|.|||:|
Human   273 FWCSIAYYELNQRVGETFH--ASQPSLTVDGFTDPSNSERFCLGLLSNVNRNATVEMTRRHIGRG 335

  Fly   610 VQLDLRGEGDVWLRCLSDNSVFVQSYYLDREAGRTPGDAVHKIYPAACIKVFDLRQCHQQMHSLA 674
            |:|...| |:|:..||||:::||||...::..|..|. .|.||.|...:|:|
Human   336 VRLYYIG-GEVFAECLSDSAIFVQSPNCNQRYGWHPA-TVCKIPPGCNLKIF------------- 385

  Fly   675 TNAQAAAAAQAAAVAGVANQQMGGGGRSMTAAAGIGVDDLRRLCILRLSFVKGWGPDYPRQSIKE 739
             |.|..||..|.:|    ||...            .|..|.|:|.:|:|||||||.:|.||::..
Human   386 -NNQEFAALLAQSV----NQGFE------------AVYQLTRMCTIRMSFVKGWGAEYRRQTVTS 433

  Fly   740 TPCWIEVHLHRALQLLDEVLHAM 762
            ||||||:||:..||.||:||..|
Human   434 TPCWIELHLNGPLQWLDKVLTQM 456

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Med	NP_524610.1	MH1_SMAD_4	42..166	CDD:199816	67/140 (48%)
		MH2_SMAD_4	543..760	CDD:199823	93/216 (43%)
SMAD2	NP_001003652.1	MH1_SMAD_2_3	8..172	CDD:199815	67/140 (48%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	207..251		19/209 (9%)
		PY-motif	221..225		3/26 (12%)
		MH2_SMAD_2_3	266..456	CDD:199826	95/226 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3701
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810