Protein Alignment Med and Smad6

DIOPT Version :9

• Sequence 1: NP_524610.1
• Gene: Med / 43725
• FlyBaseID: FBgn0011655
• Length: 771
• Species: Drosophila melanogaster
• Sequence 2: NP_001102472.2
• Gene: Smad6 / 367100
• RGDID: 1305069
• Length: 495
• Species: Rattus norvegicus
• Alignment Length: 815
• Identity: 150/815 - (18%)
• Similarity: 212/815 - (26%)
• Gaps: 436/815 - (53%)

  Fly     2 GGGSG-----ACPPAHMYGAVAPQDIIV---RDMVQMPPPPSNAPTSA----------------- 41
            |||.|     :..|..:..||.|:..::   |.....||.|.:.|.:.
  Rat    51 GGGCGRSEVRSVAPRRLRDAVGPRGALIAGRRRRTGGPPRPVSEPGAGAGGSPLDVVEPGGPGWL 115

  Fly    42 --DACLSIVHSLMCHR------------QGGES----EGFAKRAIE-----------------SL 71
              ..|.::...|...|            |..:|    ||...|:.|                 ||
  Rat   116 PESDCETVTCCLFSERDAAGAPRDSGDPQARQSPEPEEGGGPRSREARSRLLLLEQELKTVTYSL 180

  Fly    72 VKKLKEKRDELDSLITAITTNGAHPSKCVTIQRTLDGRLQVAGRKGFPHVIYARIWRWPDL-HKN 135
            :|:|||:  .||:|:.|:.:.|..|..||.:.|   ..|::.|:...|.::..|::||||| |..
  Rat   181 LKRLKER--SLDTLLEAVESRGGVPGGCVLVPR---ADLRLGGQPAPPQLLLGRLFRWPDLQHAV 240

  Fly   136 ELKHVKYC-AFAFDLKCDSVCVNPYHYERVVSPGIDLSGLSLQSGPSRLVKDEYSAGPLVGSMDI 199
            |||.:..| :||......:||.||||:.|:.
  Rat   241 ELKPLCGCHSFAAAADGPTVCCNPYHFSRLC---------------------------------- 271

  Fly   200 DGNDIGTIQHHPTQMVGPGGYGYPQGPSEYVGDANPMSAMFPTGRTIPKIEPQDGVAGSRGSWMV 264
                                     ||..
  Rat   272 -------------------------GPES------------------------------------ 275

  Fly   265 PPPP--RLGQPPQQQQQQPQQQTPQPTQQQQAQSQAAAHSLPVPHGMPGMPGPMNPGPVMAPPPP 327
            ||||  ||..|.|
  Rat   276 PPPPYSRLSPPDQ---------------------------------------------------- 288

  Fly   328 PQQAQNPQGNGVHHTQANSPTDPASALAMQQQQQQQQQQQQQQQQQQQQSGGVPNGSVNAGGGAA 392
                             :.|.|
  Rat   289 -----------------HKPLD------------------------------------------- 293

  Fly   393 AGGQYYGQPPPVSQMQGAGGGGTSVAPSVHAQQNGYVSQPGSAGSAPVGGGGVFGTAQPTPQQPQ 457
                                                                             
  Rat   294 ----------------------------------------------------------------- 293

  Fly   458 QPPTGVQANTGSAGAQAGAGGGAAGTWTGPNTLTYTQSMQPPDPRSLPGGFWNSSLSGDLGSPQQ 522
                                       ...:||:||::.......:.||.|.::|:|.|
  Rat   294 ---------------------------LSDSTLSYTETEATNSLITAPGEFSDASMSPD------ 325

  Fly   523 TPPQQQQQQQQPRLLSRQPPPEYWCSIAYFELDTQVGETFKVPSAKPNVIIDGYVDPSGGNRFCL 587
                             ...|.:|||:||:|..|:||..:.|.....::    :.|...|:.|||
  Rat   326 -----------------ATKPSHWCSVAYWEHRTRVGRLYAVYDQAVSI----FYDLPQGSGFCL 369

  Fly   588 GALSNVHRTEQSERARLHIGKGVQLDLRGEGDVWLRCLSDNSVFVQSYYLDREAGRTPGDAVHKI 652
            |.|:...|:|...|.|..||.|:.|....:| ||.....::.:||.|..||...||..  .|.|:
  Rat   370 GQLNLEQRSESVRRTRSKIGFGILLSKEPDG-VWAYNRGEHPIFVNSPTLDAPGGRAL--VVRKV 431

  Fly   653 YPAACIKVFDLRQCHQQMHSLATNAQAAAAAQAAAVAGVANQQMGGGGRSMTAAAGIGVDDLRRL 717
            .|...|||||..:.....|                                 |.|..|..|...
  Rat   432 PPGYSIKVFDFERSGLLQH---------------------------------ADAAHGPYDPHS- 462

  Fly   718 CILRLSFVKGWGPDYPRQSIKETPCWIEVHL--HR 750
              :|:||.|||||.|.||.|...|||:|:.|  ||
  Rat   463 --VRISFAKGWGPCYSRQFITSCPCWLEILLNNHR 495

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Med	NP_524610.1	MH1_SMAD_4	42..166	CDD:199816	47/158 (30%)
		MH2_SMAD_4	543..760	CDD:199823	68/210 (32%)
Smad6	NP_001102472.2	MH1_SMAD_6	161..274	CDD:199817	40/176 (23%)
		MH2_SMAD_6	323..493	CDD:199824	68/235 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3701
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810