Protein Alignment Med and Smox

DIOPT Version :9

• Sequence 1: NP_524610.1
• Gene: Med / 43725
• FlyBaseID: FBgn0011655
• Length: 771
• Species: Drosophila melanogaster
• Sequence 2: NP_001285006.1
• Gene: Smox / 31738
• FlyBaseID: FBgn0025800
• Length: 486
• Species: Drosophila melanogaster
• Alignment Length: 728
• Identity: 203/728 - (27%)
• Similarity: 286/728 - (39%)
• Gaps: 262/728 - (35%)

  Fly    47 IVHSLMCHRQGGES---EG-FAKRAIESLVKKLKEKRDELDSLITAITTNGAHPSKCVTIQRTLD 107
            :|..|:..::|.|.   || ::::|:::||||:| |..:|:.|..||:|.... ::|||:.|:..
  Fly     8 VVKRLLALKKGNEDNSVEGKWSEKAVKNLVKKIK-KNSQLEELERAISTQNCQ-TRCVTVPRSKP 70

  Fly   108 GRLQVAGRKGFPHVIYARIWRWPDLH-KNELKHVKYCAFAFDLKCDSVCVNPYHYERVVSPGIDL 171
            .......|||.|||||.|:||||||. :||||.:.:|.:||.|:.:.:|:|||||::     |:|
  Fly    71 APAGEHLRKGLPHVIYCRLWRWPDLQSQNELKPLDHCEYAFHLRKEEICINPYHYKK-----IEL 130

  Fly   172 SGLSLQSGPSRLVKDEYSAGPLVGSMDIDGNDIGTIQHHPTQMVGPGGYGYPQGPSEYVGDANPM 236
            |.|
  Fly   131 SIL-------------------------------------------------------------- 133

  Fly   237 SAMFPTGRTIPKIEPQDGVAGSRGSWMVPPPPRLGQPPQQQQQQPQQQTPQPTQQQQAQSQAAAH 301
                     :||..|             .||..:...|....   ..|.|..|....|..::|
  Fly   134 ---------VPKSLP-------------TPPDSIVDYPLDNH---THQIPNNTDYNAAIIRSA-- 171

  Fly   302 SLPVPHGMP-GMPGPMNPGPVMAPPPPPQQAQNPQGNGVHHTQANSPTDPASALAMQQQQQQQQQ 365
            ||..|..|. |..||::.....:..|    |....|.|...:.::|.:..|||...||||....|
  Fly   172 SLSPPQYMELGGAGPVSVSSSASSTP----ATAAGGGGGPSSSSSSSSSAASAYQQQQQQLSFGQ 232

  Fly   366 QQQQQQQQQQQSGGVPNGSVNAGGGAAAGGQYYGQPPPVSQMQGAGGGGTSVAPSVHAQQNGYVS 430
            ....|.........:||               .|.|||                       ||:|
  Fly   233 NMDSQSSVLSVGSSIPN---------------TGTPPP-----------------------GYMS 259

  Fly   431 QPGSAGSAPVGGGGVFGTAQPTPQQPQQPPTGVQANTGSAGAQAGAGGGAAGTWTGPNTLTYTQS 495
            :.|
  Fly   260 EDG-------------------------------------------------------------- 262

  Fly   496 MQPPDPRSLPGGFWNSSLSGDLGSPQQTPPQQQQQQQQPRLLSRQPPPEYWCSIAYFELDTQVGE 560
             .|.||..      |.::| .|..|....|....:            |.:||||:|:||:|:|||
  Fly   263 -DPIDPND------NMNMS-RLTPPADAAPVMYHE------------PAFWCSISYYELNTRVGE 307

  Fly   561 TFKVPSAKPNVIIDGYVDPSGGNRFCLGALSNVHRTEQSERARLHIGKGVQLDLRGEGDVWLRCL 625
            ||.  :::|::.:||:.|||...|||||.||||:|.|..|:.|.||||||:|...| |:|:..||
  Fly   308 TFH--ASQPSITVDGFTDPSNSERFCLGLLSNVNRNEVVEQTRRHIGKGVRLYYIG-GEVFAECL 369

  Fly   626 SDNSVFVQSYYLDREAGRTPGDAVHKIYPAACIKVFDLRQCHQQMHSLATNAQAAAAAQAAAVAG 690
            ||:|:||||...::..|..|. .|.||.|...:|:|              |.|..||
  Fly   370 SDSSIFVQSPNCNQRYGWHPA-TVCKIPPGCNLKIF--------------NNQEFAA-------- 411

  Fly   691 VANQQMGGGGRSMTAAAGIGVDDLRRLCILRLSFVKGWGPDYPRQSIKETPCWIEVHLHRALQLL 755
            :.:|.:..|..:        |..|.|:|.:|:|||||||.:|.||::..||||||:||:..||.|
  Fly   412 LLSQSVSQGFEA--------VYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWL 468

  Fly   756 DEVLHAMPIDGPR 768
            |.||..|  ..||
  Fly   469 DRVLTQM--GSPR 479

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Med	NP_524610.1	MH1_SMAD_4	42..166	CDD:199816	51/123 (41%)
		MH2_SMAD_4	543..760	CDD:199823	94/216 (44%)
Smox	NP_001285006.1	MH1_R-SMAD	7..130	CDD:199812	52/128 (41%)
		MH2_SMAD_2_3	285..475	CDD:199826	95/235 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45444266
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3701
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR13703
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840