Protein Alignment Med and smad5

DIOPT Version :9

• Sequence 1: NP_524610.1
• Gene: Med / 43725
• FlyBaseID: FBgn0011655
• Length: 771
• Species: Drosophila melanogaster
• Sequence 2: NP_001333238.1
• Gene: smad5 / 30641
• ZFINID: ZDB-GENE-990603-9
• Length: 464
• Species: Danio rerio
• Alignment Length: 737
• Identity: 209/737 - (28%)
• Similarity: 279/737 - (37%)
• Gaps: 298/737 - (40%)

  Fly    39 TSADACLSI----VHSLMCHRQGGESEGFAKRAIESLVKKLKEKRDELDSLITAITTNGAHPSKC 99
            ||..:..|.    |..|:..:||.|.|.:|::|:::||||||:|:..::.|..|:::.| .||||
Zfish     2 TSMSSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEDLEKALSSPG-QPSKC 65

  Fly   100 VTIQRTLDGRLQVAGRKGFPHVIYARIWRWPDLHK-NELKHVKYCAFAFDLKCDSVCVNPYHYER 163
            |||.|:|||||||:.|||.|||||.|:||||||.. :|||.::.|.:.|..|...||:|||||:|
Zfish    66 VTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLEVCEYPFGSKQKEVCINPYHYKR 130

  Fly   164 VVSPGIDLSGLSLQSGPSRLVKDEYSAGPLVGSMDIDGNDIGTIQHHPTQMVGPGGYGYPQGPSE 228
            |.||.:
Zfish   131 VESPVL----------------------------------------------------------- 136

  Fly   229 YVGDANPMSAMFPTGRTIPKIEPQDGVAGSRGSWMVPPPPRLGQPPQQQQQQPQQQTPQPTQQQQ 293
                                                  ||.|  .|:..:..||
Zfish   137 --------------------------------------PPVL--VPRHSEFNPQ----------- 150

  Fly   294 AQSQAAAHSLPV-----PHGMPGMPGPMNPGPVMAPPPPPQQAQNPQGNGVHHTQANSPTDPASA 353
                   |||.|     .|..|.|  |:|       ...|:..|...|........|||..|:.|
Zfish   151 -------HSLLVQFRNLSHNEPHM--PLN-------ATFPESFQQHSGGSSFPISPNSPYPPSPA 199

  Fly   354 LAMQQQQQQQQQQQQQQQQQQQQSGGVPNGSVNAGGGAAAGGQYYGQPPPVSQMQGAGGGGTSVA 418
                                  .||..||
Zfish   200 ----------------------SSGTYPN------------------------------------ 206

  Fly   419 PSVHAQQNGYVSQPGSAG-SAPVGGGGVFGTAQPTPQQPQQPPTGVQANTGSAGAQAGAGGGAAG 482
                        .|.|:| |:|      |.....||.....||.......||...:.|:...
Zfish   207 ------------SPASSGPSSP------FQLPADTPPPAYMPPDEQMGQDGSQSMETGSSLA--- 250

  Fly   483 TWTGPNTLTYTQSMQPPDPRSLPGGFWNSSLSGDLGSPQQTPPQQQQQQQQPRLLSRQPPPEYWC 547
                              |:::|.|              ...|.:.|:            |.:||
Zfish   251 ------------------PQNMPRG--------------DVQPVEYQE------------PSHWC 271

  Fly   548 SIAYFELDTQVGETFKVPSAKPNVIIDGYVDPSGG-NRFCLGALSNVHRTEQSERARLHIGKGVQ 611
            ||.|:||:.:|||.:...|.  :|::||:.|||.. ||||||.||||:|....|..|.||||||.
Zfish   272 SIVYYELNNRVGEAYHASST--SVLVDGFTDPSNNKNRFCLGLLSNVNRNSTIENTRRHIGKGVH 334

  Fly   612 LDLRGEGDVWLRCLSDNSVFVQSYYLDREAGRTPGDAVHKIYPAAC-IKVFDLRQCHQQMHSLAT 675
            |...| |:|:..||||.|:||||...:...|..| ..|.|| |:.| :|:|:    :|:.
Zfish   335 LYYVG-GEVYAECLSDTSIFVQSRNCNYHHGFHP-TTVCKI-PSGCSLKIFN----NQEF----- 387

  Fly   676 NAQAAAAAQAAAVAGVANQQMGGGGRSMTAAAGIGVDDLRRLCILRLSFVKGWGPDYPRQSIKET 740
                   ||..|      |.:..|..:        |.:|.::|.:|:|||||||.:|.||.:..|
Zfish   388 -------AQLLA------QSVNHGFEA--------VYELTKMCTIRMSFVKGWGAEYHRQDVTST 431

  Fly   741 PCWIEVHLHRALQLLDEVLHAM 762
            |||||||||..||.||:||..|
Zfish   432 PCWIEVHLHGPLQWLDKVLTQM 453

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Med	NP_524610.1	MH1_SMAD_4	42..166	CDD:199816	64/128 (50%)
		MH2_SMAD_4	543..760	CDD:199823	94/218 (43%)
smad5	NP_001333238.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	166..258		31/211 (15%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3701
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810