Protein Alignment Med and smad2

DIOPT Version :10

• Sequence 1: NP_524610.1
• Gene: Med / 43725
• FlyBaseID: FBgn0288966
• Length: 771
• Species: Drosophila melanogaster
• Sequence 2: NP_571441.3
• Gene: smad2 / 30639
• ZFINID: ZDB-GENE-990603-7
• Length: 468
• Species: Danio rerio
• Alignment Length: 738
• Identity: 199/738 - (26%)
• Similarity: 259/738 - (35%)
• Gaps: 345/738 - (46%)

  Fly    56 QGGESEGFAKRAIESLVKKLKEKRDELDSLITAITTNGAHPSKCVTI------------------ 102
            |.|:.|.:.::|::||||||| |..:||.|..||||...: :|||||
Zfish    34 QNGQEEKWCEKAVKSLVKKLK-KTGQLDELEKAITTQNRN-TKCVTIPSNCSEIWGLSTPNTIEQ 96

  Fly   103 ------------QRTLDGRLQVAGRKGFPHVIYARIWRWPDLHK-NELKHVKYCAFAFDLKCDSV 154
                        .|:|||||||:.|||.|||||.|:|||||||. :||:.::.|.:||:||.|.|
Zfish    97 WDTSGLYSYPDQTRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELRAIETCEYAFNLKKDEV 161

  Fly   155 CVNPYHYERVVSPGIDLSGLSLQSGPSRLVKDEYSAGPLVGSMDIDGNDIGTIQHHPTQMVGPGG 219
            |||||||:||.:|.:          |..||.........:..:|...|.|
Zfish   162 CVNPYHYQRVETPVL----------PPVLVPRHTEILTELPPLDDYTNSI--------------- 201

  Fly   220 YGYPQGPSEYVGDANPMSAMFPTGRTIPKIEPQDGVAGSRGSWMVPPPPRLGQPPQQQQQQPQQQ 284
                           |.:..||||     |||                             |...
Zfish   202 ---------------PENTNFPTG-----IEP-----------------------------PNNY 217

  Fly   285 TPQPTQQQQAQSQAAAHSLPVPHGMPGMPGPMNPGPVMAPPPPPQQAQNPQGNGVHHTQANSPTD 349
            .|:                                   .|||
Zfish   218 IPE-----------------------------------TPPP----------------------- 224

  Fly   350 PASALAMQQQQQQQQQQQQQQQQQQQQSGGVPNGSVNAGGGAAAGGQYYGQPPPVSQMQGAGGGG 414
                                                                             
Zfish   225 ----------------------------------------------------------------- 224

  Fly   415 TSVAPSVHAQQNGYVSQPGSAGSAPVGGGGVFGTAQPTPQQPQQPPTGVQANTGSAGAQAGAGGG 479
                        ||:|:.|.|..                   ||
Zfish   225 ------------GYISEDGEASD-------------------QQ--------------------- 237

  Fly   480 AAGTWTGPNTLTYTQSMQPPDPRSLPGGFWNSSLSGDLGSPQQTPPQQQQQQQQPRLLSRQPPPE 544
                        ..|||....|..|              ||....|.......||...|.   |.
Zfish   238 ------------MNQSMDTGSPAEL--------------SPSTLSPVNHGMDLQPVTYSE---PA 273

  Fly   545 YWCSIAYFELDTQVGETFKVPSAKPNVIIDGYVDPSGGNRFCLGALSNVHRTEQSERARLHIGKG 609
            :||||||:||:.:|||||.  :::|::.:||:.|||...|||||.||||:|....|..|.|||:|
Zfish   274 FWCSIAYYELNQRVGETFH--ASQPSLTVDGFTDPSNSERFCLGLLSNVNRNATVEMTRRHIGRG 336

  Fly   610 VQLDLRGEGDVWLRCLSDNSVFVQSYYLDREAGRTPGDAVHKIYPAACIKVFDLRQCHQQMHSLA 674
            |:|...| |:|:..||||:::||||...::..|..|. .|.||.|...:|:|
Zfish   337 VRLYYIG-GEVFAECLSDSAIFVQSPNCNQRYGWHPA-TVCKIPPGCNLKIF------------- 386

  Fly   675 TNAQAAAAAQAAAVAGVANQQMGGGGRSMTAAAGIGVDDLRRLCILRLSFVKGWGPDYPRQSIKE 739
             |.|..||..|.:|    ||...            .|..|.|:|.:|:|||||||.:|.||::..
Zfish   387 -NNQEFAALLAQSV----NQGFE------------AVYQLTRMCTIRMSFVKGWGAEYRRQTVTS 434

  Fly   740 TPCWIEVHLHRALQLLDEVLHAM 762
            ||||||:||:..||.||:||..|
Zfish   435 TPCWIELHLNGPLQWLDKVLTQM 457

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Med	NP_524610.1	MH1_SMAD_4	42..166	CDD:199816	66/140 (47%)
		MH2_SMAD_4	543..760	CDD:199823	93/216 (43%)
smad2	NP_571441.3	MH1_SMAD_2_3	8..173	CDD:199815	66/140 (47%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	224..254		15/195 (8%)
		MH2_SMAD_2_3	267..457	CDD:199826	95/226 (42%)