Protein Alignment Med and smad1

DIOPT Version :10

• Sequence 1: NP_524610.1
• Gene: Med / 43725
• FlyBaseID: FBgn0288966
• Length: 771
• Species: Drosophila melanogaster
• Sequence 2: NP_571431.2
• Gene: smad1 / 30628
• ZFINID: ZDB-GENE-991119-8
• Length: 472
• Species: Danio rerio
• Alignment Length: 718
• Identity: 207/718 - (28%)
• Similarity: 280/718 - (38%)
• Gaps: 273/718 - (38%)

  Fly    48 VHSLMCHRQGGESEGFAKRAIESLVKKLKEKRDELDSLITAITTNGAHPSKCVTIQRTLDGRLQV 112
            |..|:..:||.|.|.:|::|:::||||||:|:..::.|..|::..| .||.||||.|:|||||||
Zfish    14 VKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELERALSCPG-QPSNCVTIPRSLDGRLQV 77

  Fly   113 AGRKGFPHVIYARIWRWPDLHK-NELKHVKYCAFAFDLKCDSVCVNPYHYERVVSPGIDLSGLSL 176
            :.|||.|||||.|:||||||.. :|||.::.|.|.|..|...||:|||||:||.||
Zfish    78 SHRKGLPHVIYCRVWRWPDLQSHHELKALECCEFPFGSKQKDVCINPYHYKRVDSP--------- 133

  Fly   177 QSGPSRLVKDEYSAGPLVGSMDIDGNDIGTIQHHPTQMVGPGGYGYPQGPSEYVGDANPMSAMFP 241
                                                                          :.|
Zfish   134 --------------------------------------------------------------VLP 136

  Fly   242 TGRTIPKIEPQDGVAGSRGSWMVPPPPRLGQPPQQQQQQPQQQTPQPTQQQQAQSQAAAHSLPVP 306
                 |.:.|::....::.|.:    ||...|..|.:
Zfish   137 -----PVLVPRNSEFNAKLSML----PRFRNPLHQTE---------------------------- 164

  Fly   307 HGMPGMPGPMNPGPVMAPPPPPQQAQNPQGNGVHHTQANSPTDPASALAMQQQQQQQQQQQQQQQ 371
                              ||.||.|..|.         :.|..||:||..
Zfish   165 ------------------PPMPQNATFPD---------SFPQQPANALPF--------------- 187

  Fly   372 QQQQQSGGVPNGSVNAGGGAAAGGQYYGQPPPVSQMQGAGGGGTSVAPSVHAQQNGYVSQPGSAG 436
                    .||...|:          |...|      .:|.|.|:..|  |:..:   |.|||..
Zfish   188 --------TPNSPTNS----------YPSSP------NSGTGSTATFP--HSPSS---SDPGSPF 223

  Fly   437 SAPVGGGGVFGTAQPTPQQPQQPPTGVQANTGSAGAQAGAGGGAAGTWTGPNTLTYTQSMQPPDP 501
            ..|       .|..|....|::|.|                               ....||.|.
Zfish   224 QMP-------ETPPPAYMPPEEPMT-------------------------------QDCPQPMDT 250

  Fly   502 RSLPGGFWNSSLSGDLGSPQQTPPQQQQQQQQPRLLSRQPPPEYWCSIAYFELDTQVGETFKVPS 566
            ..|.     .:|..::.:.....|...|:            |::||||.|:||:.:|||.|...|
Zfish   251 NLLA-----PNLPLEISNRTDVHPVAYQE------------PKHWCSIVYYELNNRVGEAFLASS 298

  Fly   567 AKPNVIIDGYVDPSGG-NRFCLGALSNVHRTEQSERARLHIGKGVQLDLRGEGDVWLRCLSDNSV 630
            .  :|::||:.|||.. ||||||.||||:|....|..|.||||||.|...| |:|:..||||:|:
Zfish   299 T--SVLVDGFTDPSNNRNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVG-GEVYAECLSDSSI 360

  Fly   631 FVQSYYLDREAGRTPGDAVHKIYPAAC-IKVFDLRQCHQQMHSLATNAQAAAAAQAAAVAGVANQ 694
            ||||...:...|..| ..|.|| |:.| :|:|              |.|..|...|        |
Zfish   361 FVQSRNCNYHHGFHP-TTVCKI-PSRCSLKIF--------------NNQEFAELLA--------Q 401

  Fly   695 QMGGGGRSMTAAAGIGVDDLRRLCILRLSFVKGWGPDYPRQSIKETPCWIEVHLHRALQLLDEVL 759
            .:..|..:        |.:|.::|.:|:|||||||.:|.||.:..||||||:|||..||.||:||
Zfish   402 SVNHGFEA--------VYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVL 458

  Fly   760 HAM 762
            ..|
Zfish   459 TQM 461

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Med	NP_524610.1	MH1_SMAD_4	42..166	CDD:199816	63/118 (53%)
		MH2_SMAD_4	543..760	CDD:199823	94/218 (43%)
smad1	NP_571431.2	MH1_SMAD_1_5_9	9..132	CDD:199814	63/118 (53%)
		PTZ00449	<110..275	CDD:185628	60/398 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	158..238		31/185 (17%)
		MH2_SMAD_1_5_9	272..472	CDD:199822	97/237 (41%)