Protein Alignment Med and daf-8

DIOPT Version :9

• Sequence 1: NP_524610.1
• Gene: Med / 43725
• FlyBaseID: FBgn0011655
• Length: 771
• Species: Drosophila melanogaster
• Sequence 2: NP_492321.1
• Gene: daf-8 / 187612
• WormBaseID: WBGene00000904
• Length: 546
• Species: Caenorhabditis elegans
• Alignment Length: 706
• Identity: 136/706 - (19%)
• Similarity: 240/706 - (33%)
• Gaps: 221/706 - (31%)

  Fly    68 IESLVKKLKEKRDELDSLITAITTNGAHPSKCVTIQRTLDGRLQVAGRKGFPHVIYARIWRWPDL 132
            :..|:.::.:|....::...|: ..|...::|......     ::.|..|...:...|.:|:|.:
 Worm    40 VTRLLSRVAKKHQCFEAFYDAV-IKGDPKTRCCPAHNE-----KLIGNFGRAIMCVLRAFRFPVI 98

  Fly   133 -HKNELKHVKYCAFAFDLKCDSVCVNPYHYERVVSPGIDLSGLSLQSGPSRLVKDEYSAGPLVGS 196
             :::::|.:..|..||:....:||:|||||..|..|...:.                   |::.:
 Worm    99 RYESQVKSILTCRHAFNSHSRNVCLNPYHYRWVELPTCQVP-------------------PIIVN 144

  Fly   197 MDIDGNDIGTIQHHPTQMVGPGGYGYPQGPSE-YVGDANPMSAMFPTGRTIPKIEPQDGVAGSRG 260
            .::|                   ||.|...:| .:.|.|...           ::.:..||
 Worm   145 KELD-------------------YGEPPIRTEDALDDWNQKD-----------LKEEQVVA---- 175

  Fly   261 SWMVPPPPRLGQPPQQQQQQPQQQTPQPTQQQQAQSQAAAHSLPVPHGMPGMPGPMNPGPVMAPP 325
            ||.||                 ..|.:..:.:....:.||.:....:        ||.|
 Worm   176 SWDVP-----------------NVTMRGDEIKLLYDRYAAENGDFQY--------MNYG------ 209

  Fly   326 PPPQQAQNPQGNGVHHTQANSPTDPASALAMQQQQQQQQQQQQQQQQQQQQSGGVPNGSVNAGGG 390
                            ...:....|.|:..|..........||..:|..::.|...:|..:....
 Worm   210 ----------------NFGSFDGSPCSSTTMSLGSSFASLLQQSNRQDDEEPGYYRSGLSSPASH 258

  Fly   391 AAAGGQYYGQPPPVSQMQGAGGGGTSVAPSVHAQ----QNGYVSQPGSAGSAPVGGGGVFGTAQP 451
            ||:..::.........:.......:.|:..:|::    :|....:|..|...|:
 Worm   259 AASPREFIPNGNDTISLDQEMMDDSEVSDIMHSENFSSENNGNRKPTYADGRPI----------- 312

  Fly   452 TPQQPQQPPTGVQANTGSAGAQAGAGGGAAGTWTGPNTLTYTQSMQPPDPRSLPGGFWNSSLS-G 515
                                                         .|.:||.|   :.:|:|. |
 Worm   313 ---------------------------------------------TPIEPRPL---YRSSALELG 329

  Fly   516 DLGSPQQTPPQQQQQQQQPRLLSRQPPPEYWCSIAYFELDTQVGETFKVPSAKPNVIIDGY---- 576
            || |.|....:..:.::.|.          |..:.|:|..|.:||  |......:.:|||:
 Worm   330 DL-SRQAGIYECVEYEESPS----------WLKLIYYEEGTMIGE--KADVEGHHCLIDGFTASR 381

  Fly   577 VDPSGGNRFCLGALSNVHRTEQSERARLHIGKGVQLDLRGEGDVWLRCLSDNSVFVQSYYLDREA 641
            .|....:||.||..:|.:|:.|:...|..|||||:..|.. |:|::..|.:..|||||...:.:.
 Worm   382 TDSETRSRFSLGWYNNPNRSPQTAEVRGLIGKGVRFYLLA-GEVYVENLCNIPVFVQSIGANMKN 445

  Fly   642 GRTPGDAVHKIYPAACIKVFDLRQCHQQMHSLATNAQAAAAAQAAAVAGVANQQMGGGGRSMTAA 706
            | ...:.|.|:.|...:||||:|...:|:.:.|.....
 Worm   446 G-FQLNTVSKLPPTGTMKVFDMRLFSKQLRTAAEKTYQ--------------------------- 482

  Fly   707 AGIGVDDLRRLCILRLSFVKGWGPDYPRQSIKETPCWIEVHLHRALQLLDEVLHAM 762
               .|..|.|:|.:|:||.||||..|.|.::..:|.|.:.||:..:..:|.||..|
 Worm   483 ---DVYCLSRMCTVRVSFCKGWGEHYRRSTVLRSPVWFQAHLNNPMHWVDSVLTCM 535

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Med	NP_524610.1	MH1_SMAD_4	42..166	CDD:199816	22/98 (22%)
		MH2_SMAD_4	543..760	CDD:199823	63/220 (29%)
daf-8	NP_492321.1	DWA	32..135	CDD:214708	22/100 (22%)
		DWB	348..522	CDD:197770	60/217 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3701
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810