Protein Alignment Med and daf-3

DIOPT Version :10

• Sequence 1: NP_524610.1
• Gene: Med / 43725
• FlyBaseID: FBgn0288966
• Length: 771
• Species: Drosophila melanogaster
• Sequence 2: NP_001300341.1
• Gene: daf-3 / 180431
• WormBaseID: WBGene00000899
• Length: 895
• Species: Caenorhabditis elegans
• Alignment Length: 833
• Identity: 216/833 - (25%)
• Similarity: 303/833 - (36%)
• Gaps: 260/833 - (31%)

  Fly    33 PPSNAPTSADACLSIVHSLMCHRQGGESE-------------------------GFAKRAIESLV 72
            |.::||.:     .||..||.:|...|||                         .|.::|.||||
 Worm   190 PDASAPPN-----KIVEYLMYYRTLKESELIQLNAYRTKRNRLSLNLVKNNIDREFDQKACESLV 249

  Fly    73 KKLKEKRDELDSLITAITTNGAHPSKCVTIQRTLDGRLQVAGRKGFPHVIYARIWRWPDLHKNEL 137
            ||||:|:::|.:||..:.:.|...:.|:||.|||||||||.||||||||:|.::||:.::.|||.
 Worm   250 KKLKDKKNDLQNLIDVVLSKGTKYTGCITIPRTLDGRLQVHGRKGFPHVVYGKLWRFNEMTKNET 314

  Fly   138 KHVKYCAFAFDLKCD---SVCVNPYHYERVVSPGIDLSGLSLQSGPSRLVKDEYSAGPLVGSMDI 199
            :||.:|..||::|.|   .|||||||||.|:...|                        ||..|.
 Worm   315 RHVDHCKHAFEMKSDMVGEVCVNPYHYEIVIGTMI------------------------VGQRDH 355

  Fly   200 DGNDIGTIQHHPTQMVGPGGYGYPQGPSEYVGDANPMSAMFPTGRTIPKIEPQDGVAGSRGSWMV 264
            |..|:..    |.|.     |..|       |..:|:..|   .|.|
 Worm   356 DNRDMPP----PHQR-----YHTP-------GRQDPVDDM---SRFI------------------ 383

  Fly   265 PPPPRLGQPPQQQQQQPQQQTPQPTQQQQAQSQAAAHSLPVPHGMPGMPGPMNPGPVMAPP---- 325
             ||..:..||.....:||   |.|   ||..|..|..:.|:||..|..||..:|..: ||.
 Worm   384 -PPASIRPPPMNMHTRPQ---PMP---QQLPSVGATFAHPLPHQAPHNPGVSHPYSI-APQTHYP 440

  Fly   326 ----PPPQQAQNPQGNGVHHTQANSPTDPASALAMQQQQQQQQQQQQQQQQQQQQSGGVPNGSVN 386
                |.||..|.||
 Worm   441 LNMNPIPQMPQMPQ--------------------------------------------------- 454

  Fly   387 AGGGAAAGGQYYGQPPPVSQMQGAGGGGTSVAPSVHAQQNGY---VSQPG--SAGSAPVGGGGVF 446
                         .|||:.|..|..|...|...:....||.:   :|.|.  |....|    .::
 Worm   455 -------------MPPPLHQGYGMNGPSCSSENNNPFHQNHHYNDISHPNHYSYDCGP----NLY 502

  Fly   447 GTAQPTP-------QQPQQPPTGVQANTGSAGA-QAGAGGGAAGTWTGPNTLTYTQSMQPPDPRS 503
            |...|.|       |||.|||...|.:|...|: |.|..|..      ||....::.:..|...:
 Worm   503 GFPTPYPDFHHPFNQQPHQPPQLSQNHTSQQGSHQPGHQGQV------PNDPPISRPVLQPSTVT 561

  Fly   504 LP-------GGFWNSSLSG-----------------DLGSP----QQTPPQQQQQQQQPRLLSRQ 540
            |.       ..|.|....|                 :..||    ....|:....:....::...
 Worm   562 LDVFRRYCRQTFGNRFFEGESEQSGAIIRSSNKFIEEFDSPICGVTVVRPRMTDGEVLENIMPED 626

  Fly   541 PP----------------------PEY------WCSIAYFELDTQVGETFKVPSAKPNVIID-GY 576
            .|                      ||.      |.:|.|:|.:.|:||.   ..::.|..:| |:
 Worm   627 APYHDICKFILRLTSESVTFSGEGPEVSDLNEKWGTIVYYEKNLQIGEK---KCSRGNFHVDGGF 688

  Fly   577 VDPSGGNRFCLGALSNVHRTEQSERARLHIGKGVQLDLRGEGDVWLRCLSDNSVFVQSYYLDREA 641
            :  ...||:.||...|..|...:.:.|..|..|::...:.:|.|||:......|||.|.|||.::
 Worm   689 I--CSENRYSLGLEPNPIREPVAFKVRKAIVDGIRFSYKKDGSVWLQNRMKYPVFVTSGYLDEQS 751

  Fly   642 GRTPGDAVHKIYPAACIKVFDLRQCHQQMHSLATNAQAAAAAQAAAVAGVANQQMGGGGRSMTAA 706
            |....|.|||:|..|.||.|......|.:.....:.|.|.......:..:...........:...
 Worm   752 GGLKKDKVHKVYGCASIKTFGFNVSKQIIRDALLSKQMATMYLQGKLTPMNYIYEKKTQEELRRE 816

  Fly   707 AGIGVDDLRRLCILRLSFVKGWGPDYP-RQSIKETPCWIEVHLHRALQLLDEV 758
            |....|.|.:.|.:|:||.||:|..|| |.||.:.|.|||:.::.|...:|.:
 Worm   817 ATRTTDSLAKYCCVRVSFCKGFGEAYPERPSIHDCPVWIELKINIAYDFMDSI 869

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Med	NP_524610.1	MH1_SMAD_4	42..166	CDD:199816	66/151 (44%)
		MH2_SMAD_4	543..760	CDD:199823	66/224 (29%)
daf-3	NP_001300341.1	MH1_SMAD_4	218..346	CDD:199816	58/127 (46%)
		Atrophin-1	<355..>560	CDD:460830	69/323 (21%)
		DWB	659..860	CDD:197770	62/205 (30%)