DRSC/TRiP Functional Genomics Resources

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Protein Alignment Med and daf-3

DIOPT Version :9

Sequence 1:NP_524610.1 Gene:Med / 43725 FlyBaseID:FBgn0011655 Length:771 Species:Drosophila melanogaster
Sequence 2:NP_001300341.1 Gene:daf-3 / 180431 WormBaseID:WBGene00000899 Length:895 Species:Caenorhabditis elegans


Alignment Length:833 Identity:216/833 - (25%)
Similarity:303/833 - (36%) Gaps:260/833 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    33 PPSNAPTSADACLSIVHSLMCHRQGGESE-------------------------GFAKRAIESLV 72
            |.::||.:     .||..||.:|...|||                         .|.::|.||||
 Worm   190 PDASAPPN-----KIVEYLMYYRTLKESELIQLNAYRTKRNRLSLNLVKNNIDREFDQKACESLV 249

  Fly    73 KKLKEKRDELDSLITAITTNGAHPSKCVTIQRTLDGRLQVAGRKGFPHVIYARIWRWPDLHKNEL 137
            ||||:|:::|.:||..:.:.|...:.|:||.|||||||||.||||||||:|.::||:.::.|||.
 Worm   250 KKLKDKKNDLQNLIDVVLSKGTKYTGCITIPRTLDGRLQVHGRKGFPHVVYGKLWRFNEMTKNET 314

  Fly   138 KHVKYCAFAFDLKCD---SVCVNPYHYERVVSPGIDLSGLSLQSGPSRLVKDEYSAGPLVGSMDI 199
            :||.:|..||::|.|   .|||||||||.|:...|                        ||..|.
 Worm   315 RHVDHCKHAFEMKSDMVGEVCVNPYHYEIVIGTMI------------------------VGQRDH 355

  Fly   200 DGNDIGTIQHHPTQMVGPGGYGYPQGPSEYVGDANPMSAMFPTGRTIPKIEPQDGVAGSRGSWMV 264
            |..|:..    |.|.     |..|       |..:|:..|   .|.|                  
 Worm   356 DNRDMPP----PHQR-----YHTP-------GRQDPVDDM---SRFI------------------ 383

  Fly   265 PPPPRLGQPPQQQQQQPQQQTPQPTQQQQAQSQAAAHSLPVPHGMPGMPGPMNPGPVMAPP---- 325
             ||..:..||.....:||   |.|   ||..|..|..:.|:||..|..||..:|..: ||.    
 Worm   384 -PPASIRPPPMNMHTRPQ---PMP---QQLPSVGATFAHPLPHQAPHNPGVSHPYSI-APQTHYP 440

  Fly   326 ----PPPQQAQNPQGNGVHHTQANSPTDPASALAMQQQQQQQQQQQQQQQQQQQQSGGVPNGSVN 386
                |.||..|.||                                                   
 Worm   441 LNMNPIPQMPQMPQ--------------------------------------------------- 454

  Fly   387 AGGGAAAGGQYYGQPPPVSQMQGAGGGGTSVAPSVHAQQNGY---VSQPG--SAGSAPVGGGGVF 446
                         .|||:.|..|..|...|...:....||.:   :|.|.  |....|    .::
 Worm   455 -------------MPPPLHQGYGMNGPSCSSENNNPFHQNHHYNDISHPNHYSYDCGP----NLY 502

  Fly   447 GTAQPTP-------QQPQQPPTGVQANTGSAGA-QAGAGGGAAGTWTGPNTLTYTQSMQPPDPRS 503
            |...|.|       |||.|||...|.:|...|: |.|..|..      ||....::.:..|...:
 Worm   503 GFPTPYPDFHHPFNQQPHQPPQLSQNHTSQQGSHQPGHQGQV------PNDPPISRPVLQPSTVT 561

  Fly   504 LP-------GGFWNSSLSG-----------------DLGSP----QQTPPQQQQQQQQPRLLSRQ 540
            |.       ..|.|....|                 :..||    ....|:....:....::...
 Worm   562 LDVFRRYCRQTFGNRFFEGESEQSGAIIRSSNKFIEEFDSPICGVTVVRPRMTDGEVLENIMPED 626

  Fly   541 PP----------------------PEY------WCSIAYFELDTQVGETFKVPSAKPNVIID-GY 576
            .|                      ||.      |.:|.|:|.:.|:||.   ..::.|..:| |:
 Worm   627 APYHDICKFILRLTSESVTFSGEGPEVSDLNEKWGTIVYYEKNLQIGEK---KCSRGNFHVDGGF 688

  Fly   577 VDPSGGNRFCLGALSNVHRTEQSERARLHIGKGVQLDLRGEGDVWLRCLSDNSVFVQSYYLDREA 641
            :  ...||:.||...|..|...:.:.|..|..|::...:.:|.|||:......|||.|.|||.::
 Worm   689 I--CSENRYSLGLEPNPIREPVAFKVRKAIVDGIRFSYKKDGSVWLQNRMKYPVFVTSGYLDEQS 751

  Fly   642 GRTPGDAVHKIYPAACIKVFDLRQCHQQMHSLATNAQAAAAAQAAAVAGVANQQMGGGGRSMTAA 706
            |....|.|||:|..|.||.|......|.:.....:.|.|.......:..:...........:...
 Worm   752 GGLKKDKVHKVYGCASIKTFGFNVSKQIIRDALLSKQMATMYLQGKLTPMNYIYEKKTQEELRRE 816

  Fly   707 AGIGVDDLRRLCILRLSFVKGWGPDYP-RQSIKETPCWIEVHLHRALQLLDEV 758
            |....|.|.:.|.:|:||.||:|..|| |.||.:.|.|||:.::.|...:|.:
 Worm   817 ATRTTDSLAKYCCVRVSFCKGFGEAYPERPSIHDCPVWIELKINIAYDFMDSI 869

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MedNP_524610.1 MH1_SMAD_4 42..166 CDD:199816 66/151 (44%)
MH2_SMAD_4 543..760 CDD:199823 66/224 (29%)
daf-3NP_001300341.1 MH1_SMAD_4 218..346 CDD:199816 58/127 (46%)
DWB 659..860 CDD:197770 62/205 (30%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S5208
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR13703
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.960

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