Protein Alignment Med and sma-2

DIOPT Version :9

• Sequence 1: NP_524610.1
• Gene: Med / 43725
• FlyBaseID: FBgn0011655
• Length: 771
• Species: Drosophila melanogaster
• Sequence 2: NP_001370321.1
• Gene: sma-2 / 176229
• WormBaseID: WBGene00004856
• Length: 418
• Species: Caenorhabditis elegans
• Alignment Length: 723
• Identity: 164/723 - (22%)
• Similarity: 243/723 - (33%)
• Gaps: 340/723 - (47%)

  Fly    55 RQGGESEGFAKRAIESLVKKL-KEKRDELDSLITAITTNGAHPSKCVTIQRTLDGRLQVAGRKGF 118
            :||.|.|.:||:||::|:||| |..:..|::|..|:...|...::||||.|:||||||::.||..
 Worm    17 KQGDEDENWAKKAIDNLMKKLIKHNKQALENLEFALRCQGQQKTECVTIPRSLDGRLQISHRKAL 81

  Fly   119 PHVIYARIWRWPDLHK-NELKHVKYCAFAFDLKCDSVCVNPYHYERVVSPGIDLSGLSLQSGPSR 182
            |||||.|::|||||.. :|||.::.|.|.::.....:|:|||||:||.:.|:
 Worm    82 PHVIYCRVYRWPDLQSHHELKAIEDCRFCYESGQKDICINPYHYKRVHATGV------------- 133

  Fly   183 LVKDEYSAGPLVGSMDIDGNDIGTIQHHPTQMVGPGGYGYPQGPSEYVGDANPMSAMFPTGRTIP 247
                                                                           :|
 Worm   134 ---------------------------------------------------------------LP 135

  Fly   248 KIEPQDGVAGSRGSWMVPPPPRLGQPPQQQQQQPQQQTPQPTQQQQAQSQAAAHSLPVPHGMPGM 312
            .:             :||          :..::|.|:.|....:.|....:.:.          |
 Worm   136 PV-------------LVP----------RYSEKPPQEVPPTLAKFQLMEMSGSR----------M 167

  Fly   313 PGPMNPGPVMAPPPPPQQAQNPQGNGVHHTQANSPTDPASALAMQQQQQQQQQQQQQQQQQQQQS 377
            |..:|...|           |...|..|  |.|
 Worm   168 PQNVNMANV-----------NFTANQFH--QYN-------------------------------- 187

  Fly   378 GGVPNGSVNAGGGAAAGGQYYGQPPPVSQMQGAGGGGTSVAPSVHAQQNGYVSQPGSAGSAPVGG 442
               |||                    :.:|.
 Worm   188 ---PNG--------------------IEEMD---------------------------------- 195

  Fly   443 GGVFGTAQPTPQQPQQPPTGVQANTGSAGAQAGAGGGAAGTWTGPNTLTYTQSMQPPDPRSLPGG 507
                     |.|:...||
 Worm   196 ---------TSQKFDIPP----------------------------------------------- 204

  Fly   508 FWNSSLSGDLGSPQQTPPQQQQQQQQPRLLSRQPPPEYWCSIAYFELDTQVGETFKVPSAKPNVI 572
                      |.|....|..:..::|           :|.:::|:||:|:|||..||.|.  .:.
 Worm   205 ----------GVPTCLVPFDKVWEEQ-----------FWATVSYYELNTRVGEQVKVSST--TIT 246

  Fly   573 IDGYVDPS-GGNRFCLGALSNVHRTEQSERARLHIGKGVQLD-LRGEGDVWLRCLSDNSVFVQS- 634
            |||:.||. .|::..||..|||:|....|..|.|||.||:|. :|..|.::.:|.||:::||||
 Worm   247 IDGFTDPCINGSKISLGLFSNVNRNATIENTRRHIGNGVKLTYVRSNGSLFAQCESDSAIFVQSS 311

  Fly   635 --YYLDREAGRTPGDAVHKIYPAACIKVFDLRQCHQQMHSLATNAQAAAAAQAAAVAGVANQQMG 697
              .|::.....|    |.||.....:|:||:....|.:...:..
 Worm   312 NCNYINGFHSTT----VVKIANKCSLKIFDMEIFRQLLEDCSRR--------------------- 351

  Fly   698 GGGRSMTAAAGIGVD---DLRRLCILRLSFVKGWGPDYPRQSIKETPCWIEVHLHRALQLLDEVL 759
                        |.|   ||:::..:|:|||||||.:|.||.:..||||||:|||..|..||.||
 Worm   352 ------------GFDASFDLQKMTFIRMSFVKGWGAEYQRQDVTSTPCWIEIHLHAPLAWLDRVL 404

  Fly   760 HAMPIDGP 767
            ..|   ||
 Worm   405 STM---GP 409

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Med	NP_524610.1	MH1_SMAD_4	42..166	CDD:199816	54/112 (48%)
		MH2_SMAD_4	543..760	CDD:199823	77/224 (34%)
sma-2	NP_001370321.1	MH1	5..130	CDD:412134	54/112 (48%)
		MH2_R-SMAD	222..405	CDD:199820	77/221 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3701
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810