Protein Alignment Med and sma-3

DIOPT Version :9

• Sequence 1: NP_524610.1
• Gene: Med / 43725
• FlyBaseID: FBgn0011655
• Length: 771
• Species: Drosophila melanogaster
• Sequence 2: NP_498493.1
• Gene: sma-3 / 175955
• WormBaseID: WBGene00004857
• Length: 393
• Species: Caenorhabditis elegans
• Alignment Length: 726
• Identity: 150/726 - (20%)
• Similarity: 233/726 - (32%)
• Gaps: 365/726 - (50%)

  Fly    48 VHSLMCHRQGGESEGFAKRAIESLVKKLKEKRDELDSL--ITAITTNGAHPSKCVTIQRTLDGRL 110
            |..|:..:.|.:.|.:.::|:|:||||||:|.:...:|  :..:..|....|:|:||.::|||||
 Worm    12 VKKLLGWKIGEDEEKWCEKAVEALVKKLKKKNNGCGTLEDLECVLANPCTNSRCITIAKSLDGRL 76

  Fly   111 QVAGRKGFPHVIYARIWRWPDLHK-NELKHVKYCAFAFD--LKCDSVCVNPYHYERVVSPGIDLS 172
            ||:.:||.|||||.|:|||||:.. :||:.:..|::.::  .|...:|:|||||:|:
 Worm    77 QVSHKKGLPHVIYCRVWRWPDISSPHELRSIDTCSYPYESSSKTMYICINPYHYQRL-------- 133

  Fly   173 GLSLQSGPSRLVKDEYSAGPLVGSMDIDGNDIGTIQHHPTQMVGPGGYGYPQGPSEYVGDANPMS 237
                    ||                                        |||.:.
 Worm   134 --------SR----------------------------------------PQGLNS--------- 141

  Fly   238 AMFPTGRTIPKIEPQDGVAGSRGSWMVPPPPRLGQPPQQQQQQPQQQTPQPTQQQQAQSQAAAHS 302
                                                                            |
 Worm   142 ----------------------------------------------------------------S 142

  Fly   303 LPVPHGMPGMPGPMNPGPVMAPPPPPQQAQNPQGNGVHHTQANSPTDPASALAMQQQQQQQQQQQ 367
            :|            :|.|:.:|            |.:..:..:|....||
 Worm   143 MP------------SPQPISSP------------NTIWQSSGSSTASCAS--------------- 168

  Fly   368 QQQQQQQQQSGGVPNGSVNAGGGAAAGGQYYGQPPPVSQMQGAGGGGTSVAPSVHAQQNGYVSQP 432
                                                            |.:|||.::..|.|
 Worm   169 ------------------------------------------------SPSPSVFSEDGGEV--- 182

  Fly   433 GSAGSAPVGGGGVFGTAQPTPQQPQQPPTGVQANTGSAGAQAGAGGGAAGTWTGPNTLTYTQSMQ 497
                                                                             
 Worm   183 ----------------------------------------------------------------- 182

  Fly   498 PPDPRSLPGGFWNSSLSGDLGSPQQTPPQQQQQQQQPRLLSRQPP---PEYWCSIAYFELDTQVG 559
                                           |..|:|      ||   |:.|..|.||||:::||
 Worm   183 -------------------------------QVHQRP------PPFRHPKSWAQITYFELNSRVG 210

  Fly   560 ETFKVPSAKPNVIIDGYVDPSGGN-RFCLGALSNVHRTEQSERARLHIGKGVQLDLR-GEGDVWL 622
            |.||:.:.  ::.:|||.:||..| |.|||.|:||:|....|..|:|||||:|||.: .:..:.:
 Worm   211 EVFKLVNL--SITVDGYTNPSNSNTRICLGQLTNVNRNGTIENTRMHIGKGIQLDNKEDQMHIMI 273

  Fly   623 RCLSDNSVFVQSYYLDREAGRTPGDAVHKIYPAACIKVFDLRQCHQQMHSLATNAQAAAAAQAAA 687
            ...||..|||||...:... ..|...|.:|.|.:.:.||:.....|.:.....::.
 Worm   274 TNNSDMPVFVQSKNTNLMM-NMPLVKVCRIPPHSQLCVFEFNLFFQMLEQSCNDSD--------- 328

  Fly   688 VAGVANQQMGGGGRSMTAAAGIGVDDLRRLCILRLSFVKGWGPDYPRQSIKETPCWIEVHLHRAL 752
                                  |:::|.:.|.:|:|||||||.|||||.:..||||:|:.|:..|
 Worm   329 ----------------------GLNELSKHCFIRISFVKGWGEDYPRQDVTSTPCWLELRLNVPL 371

  Fly   753 QLLDEVLHAMP 763
            ..:|:.:...|
 Worm   372 AYIDQKMKQTP 382

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Med	NP_524610.1	MH1_SMAD_4	42..166	CDD:199816	50/122 (41%)
		MH2_SMAD_4	543..760	CDD:199823	74/218 (34%)
sma-3	NP_498493.1	MH1	10..133	CDD:260161	49/120 (41%)
		MH2_R-SMAD	197..379	CDD:199820	73/215 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3701
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810