DRSC/TRiP Functional Genomics Resources

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Protein Alignment Med and sma-4

DIOPT Version :9

Sequence 1:NP_524610.1 Gene:Med / 43725 FlyBaseID:FBgn0011655 Length:771 Species:Drosophila melanogaster
Sequence 2:NP_001040864.1 Gene:sma-4 / 175815 WormBaseID:WBGene00004858 Length:565 Species:Caenorhabditis elegans


Alignment Length:754 Identity:233/754 - (30%)
Similarity:294/754 - (38%) Gaps:339/754 - (44%)


- Green bases have known domain annotations that are detailed below.


  Fly    31 PPP---------PSNA----PTSADACLSIVHSLMCHRQGGESEGFAKRAIESLVKKLKEKRDEL 82
            |||         |.||    .|:.|:|..|.|.|.|::||||...|.::||||||||||:||.||
 Worm   117 PPPTPTVNPTPIPPNAGAVLTTAMDSCQQISHVLQCYQQGGEDSDFVRKAIESLVKKLKDKRIEL 181

  Fly    83 DSLITAITTNGAHPSKCVTIQRTLDGRLQVAGRKGFPHVIYARIWRWPDLHKNELKHVKYCAFAF 147
            |:||||:|:||..|:.||||||:||||||||||||.|||:||||||||.:.||||..:..|..:.
 Worm   182 DALITAVTSNGKQPTGCVTIQRSLDGRLQVAGRKGVPHVVYARIWRWPKVSKNELVKLVQCQTSS 246

  Fly   148 DLKCDSVCVNPYHYERVVSPGIDLSGLSLQSGPSRLVKDEYSAGPLVGSMDIDGNDIGTIQHHPT 212
            | ..|::|:||||||||||..|..:..||.                             :::.|.
 Worm   247 D-HPDNICINPYHYERVVSNRITSADQSLH-----------------------------VENSPM 281

  Fly   213 QMVGPGGYGYPQGPSEYVGDANPMSAMFPTGRTIPKIEPQDGVAGSRGSWMVPPPPRLGQPPQQQ 277
            :             |||:|||                    ||..|...|               
 Worm   282 K-------------SEYLGDA--------------------GVIDSCSDW--------------- 298

  Fly   278 QQQPQQQTPQPTQQQQAQSQAAAHSLPVPHGMPGMPGPMNPGPVMAPPPPPQQAQNPQGNGVHHT 342
                                                          |..||..            
 Worm   299 ----------------------------------------------PNTPPDN------------ 305

  Fly   343 QANSPTDPASALAMQQQQQQQQQQQQQQQQQQQQSGGVPNGSVNAGGGAAAGGQYYGQPPPVSQM 407
                                                       |..||.|               
 Worm   306 -------------------------------------------NFNGGFA--------------- 312

  Fly   408 QGAGGGGTSVAPSVHAQQNGYVSQPGSAGSAPVGGGGVFGTAQPTPQQPQQPPTGVQANTGSAGA 472
                                                         |.|||               
 Worm   313 ---------------------------------------------PDQPQ--------------- 317

  Fly   473 QAGAGGGAAGTWTGPNTLTYTQSMQPPDPRSL--PGGFWNSSLSGDLGSPQQTPPQQQQQQQQPR 535
                            .:|...|..|.|...:  |                 ||||         
 Worm   318 ----------------LVTPIISDIPIDLNQIYVP-----------------TPPQ--------- 340

  Fly   536 LLSRQPPPEYWCSIAYFELDTQVGETFKVPSAKPN--VIIDGYVDPSGGN--RFCLGALSNVHRT 596
            ||      :.||||.|:||||.:|||||| ||:.:  ||:||.:||.|.|  |.|||||||||||
 Worm   341 LL------DNWCSIIYYELDTPIGETFKV-SARDHGKVIVDGGMDPHGENEGRLCLGALSNVHRT 398

  Fly   597 EQSERARLHIGKGVQLDLRGEGDVWLRCLSDNSVFVQSYYLDREAGRTPGDAVHKIYP-AACIKV 660
            |.||:||:|||:||:|....:|::.:  .|:..:||:|.|||...|.......|:..| .:...|
 Worm   399 EASEKARIHIGRGVELTAHADGNISI--TSNCKIFVRSGYLDYTHGSEYSSKAHRFTPNESSFTV 461

  Fly   661 FDLRQCHQQMHSLATNAQAAAAAQAAAVAGVANQQMGGGGRSMTAAAGI----GVDDLRR-LCIL 720
            ||:|..:.||...:.::..|..||||||||.|         .|:....|    |||.:|| .|.:
 Worm   462 FDIRWAYMQMLRRSRSSNEAVRAQAAAVAGYA---------PMSVMPAIMPDSGVDRMRRDFCTI 517

  Fly   721 RLSFVKGWGPDYPRQSIKETPCWIEVHLHRALQLLDEVL 759
            .:||||.||..|.|::||||||||||.|||.||:||::|
 Worm   518 AISFVKAWGDVYQRKTIKETPCWIEVTLHRPLQILDQLL 556

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MedNP_524610.1 MH1_SMAD_4 42..166 CDD:199816 79/123 (64%)
MH2_SMAD_4 543..760 CDD:199823 109/227 (48%)
sma-4NP_001040864.1 MH1_SMAD_4 141..264 CDD:199816 79/123 (64%)
MH2 343..557 CDD:294046 109/226 (48%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C160166831
Domainoid 1 1.000 173 1.000 Domainoid score I2215
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 365 1.000 Inparanoid score I1259
Isobase 1 0.950 - 0 Normalized mean entropy S5208
OMA 1 1.010 - - QHG48996
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0004851
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_105347
Panther 1 1.100 - - LDO PTHR13703
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R5008
SonicParanoid 1 1.000 - - X3979
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1312.880

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