Protein Alignment Med and Smad6

DIOPT Version :9

• Sequence 1: NP_524610.1
• Gene: Med / 43725
• FlyBaseID: FBgn0011655
• Length: 771
• Species: Drosophila melanogaster
• Sequence 2: NP_032568.3
• Gene: Smad6 / 17130
• MGIID: 1336883
• Length: 495
• Species: Mus musculus
• Alignment Length: 641
• Identity: 150/641 - (23%)
• Similarity: 212/641 - (33%)
• Gaps: 214/641 - (33%)

  Fly   172 SGLSLQSGPSRLVKDEYSAGPLVGSMDIDGNDIGTIQHHPTQMVGPGGYGYPQGPSEYVGDANPM 236
            |||..:...||:|.|........|.:|.||: :|: :..|......|| |..:.....|....|.
Mouse     7 SGLVRRLWRSRVVPDREEGSGGGGGVDEDGS-LGS-RAEPAPRAREGG-GCSRSEVRSVAPRRPR 68

  Fly   237 SAMFPTGRTIPKIEPQDGVAGSRGSWMVPPPPRLGQPPQQQQQQPQQQTPQPTQQQQAQSQAAAH 301
            .|:.|.|..|         ||.|        .|.|            ..|:|.    ::|.|.|.
Mouse    69 DAVGPRGAAI---------AGRR--------RRTG------------GLPRPV----SESGAGAG 100

  Fly   302 SLPVPHGMPGMPG-----------------------PMNPGPVMAPPPPPQQAQNP---QGNGVH 340
            ..|:....||.||                       |.:.|       .||..|:|   :|.|..
Mouse   101 GSPLDVAEPGGPGWLPESDCETVTCCLFSERDAAGAPRDSG-------DPQARQSPEPEEGGGPR 158

  Fly   341 HTQANSPTDPASALAMQQQ---------QQQQQQQQQQQQQQQQQSGGVPNGSVNAGGGAAAGGQ 396
            ..:|.|     ..|.::|:         ::.:::......:..:..||||.|.|..   ..|..:
Mouse   159 SREARS-----RLLLLEQELKTVTYSLLKRLKERSLDTLLEAVESRGGVPGGCVLV---PRADLR 215

  Fly   397 YYGQPPPVSQMQG-------------------------AGGGGTSVAPSVHAQQNGYVSQPGSAG 436
            ..|||.|...:.|                         |..|.|......|..:   :..|.|
Mouse   216 LGGQPAPPQLLLGRLFRWPDLQHAVELKPLCGCHSFTAAADGPTVCCNPYHFSR---LCGPES-- 275

  Fly   437 SAPVGGGGVFGTAQPTPQQPQQPPTGVQANTGSAGAQAGAGGGAAGTWTGPNTLTYTQSMQPPDP 501
                         .|.|.....||...:....|                 .:||:||::......
Mouse   276 -------------PPPPYSRLSPPDQYKPLDLS-----------------DSTLSYTETEATNSL 310

  Fly   502 RSLPGGFWNSSLSGDLGSPQQTPPQQQQQQQQPRLLSRQPPPEYWCSIAYFELDTQVGETFKVPS 566
            .:.||.|.::|:|.|                       ...|.:|||:||:|..|:||..:.|..
Mouse   311 ITAPGEFSDASMSPD-----------------------ATKPSHWCSVAYWEHRTRVGRLYAVYD 352

  Fly   567 AKPNVIIDGYVDPSGGNRFCLGALSNVHRTEQSERARLHIGKGVQLDLRGEGDVWLRCLSDNSVF 631
            ...::    :.|...|:.||||.|:...|:|...|.|..||.|:.|....:| ||.....::.:|
Mouse   353 QAVSI----FYDLPQGSGFCLGQLNLEQRSESVRRTRSKIGFGILLSKEPDG-VWAYNRGEHPIF 412

  Fly   632 VQSYYLDREAGRTPGDAVHKIYPAACIKVFDLRQCHQQMHSLATNAQAAAAAQAAAVAGVANQQM 696
            |.|..||...||..  .|.|:.|...|||||..:.....|
Mouse   413 VNSPTLDAPGGRAL--VVRKVPPGYSIKVFDFERSGLLQH------------------------- 450

  Fly   697 GGGGRSMTAAAGIGVDDLRRLCILRLSFVKGWGPDYPRQSIKETPCWIEVHL--HR 750
                    |.|..|..|...   :|:||.|||||.|.||.|...|||:|:.|  ||
Mouse   451 --------ADAAHGPYDPHS---VRISFAKGWGPCYSRQFITSCPCWLEILLNNHR 495

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Med	NP_524610.1	MH1_SMAD_4	42..166	CDD:199816
		MH2_SMAD_4	543..760	CDD:199823	68/210 (32%)
Smad6	NP_032568.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..115		37/143 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	133..161		8/34 (24%)
		MH1_SMAD_6	161..274	CDD:199817	20/123 (16%)
		MH2_SMAD_6	323..493	CDD:199824	68/235 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3701
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810