Protein Alignment Med and Smad5

DIOPT Version :9

• Sequence 1: NP_524610.1
• Gene: Med / 43725
• FlyBaseID: FBgn0011655
• Length: 771
• Species: Drosophila melanogaster
• Sequence 2: NP_001157513.1
• Gene: Smad5 / 17129
• MGIID: 1328787
• Length: 465
• Species: Mus musculus
• Alignment Length: 725
• Identity: 208/725 - (28%)
• Similarity: 279/725 - (38%)
• Gaps: 295/725 - (40%)

  Fly    48 VHSLMCHRQGGESEGFAKRAIESLVKKLKEKRDELDSLITAITTNGAHPSKCVTIQRTLDGRLQV 112
            |..|:..:||.|.|.:|::|:::||||||:|:..::.|..|:::.| .|||||||.|:|||||||
Mouse    15 VKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALSSPG-QPSKCVTIPRSLDGRLQV 78

  Fly   113 AGRKGFPHVIYARIWRWPDLHK-NELKHVKYCAFAFDLKCDSVCVNPYHYERVVSPGIDLSGLSL 176
            :.|||.|||||.|:||||||.. :|||.:..|.|.|..|...||:|||||:||.||.:
Mouse    79 SHRKGLPHVIYCRVWRWPDLQSHHELKPLDICEFPFGSKQKEVCINPYHYKRVESPVL------- 136

  Fly   177 QSGPSRLVKDEYSAGPLVGSMDIDGNDIGTIQHHPTQMVGPGGYGYPQGPSEYVGDANPMSAMFP 241
               |..||.                      :|:                     :.||..::..
Mouse   137 ---PPVLVP----------------------RHN---------------------EFNPQHSLLV 155

  Fly   242 TGRTIPKIEPQDGVAGSRGSWMVPPPPRLGQPPQQQQQQPQQQT-PQPTQQQQAQSQAAAHSLPV 305
            ..|.:...||                           ..||..| |....|..
Mouse   156 QFRNLSHNEP---------------------------HMPQNATFPDSFHQPN------------ 181

  Fly   306 PHGMPGMPGPMNPGPVMAPPPPPQQAQNPQGNGVHHTQANSPTDPASALAMQQQQQQQQQQQQQQ 370
                 ..|.|::|                          |||..|:.|
Mouse   182 -----NAPFPLSP--------------------------NSPYPPSPA----------------- 198

  Fly   371 QQQQQQSGGVPNGSVNAGGGAAAGGQYYGQPPPVSQMQGAGGGGTSVAPSVHAQQNGYVSQPGSA 435
                  |...||...::|                                           |||.
Mouse   199 ------SSTYPNSPASSG-------------------------------------------PGSP 214

  Fly   436 GSAPVGGGGVFGTAQPTPQQPQQPPTGVQANTGSAGAQAGAGGGAAGTWTGPNTLTYTQSMQPPD 500
            ...|.          .||     ||                                  :..|||
Mouse   215 FQLPA----------DTP-----PP----------------------------------AYMPPD 230

  Fly   501 PRSLPGGFWNSSLSGDLGSPQQTPPQQQQQQQQPRLLSR--QP----PPEYWCSIAYFELDTQVG 559
            .:..|          |...|..| ......|..|.:.||  ||    .|::||||.|:||:.:||
Mouse   231 DQMAP----------DNSQPMDT-SSNMIPQTMPSISSRDVQPVAYEEPKHWCSIVYYELNNRVG 284

  Fly   560 ETFKVPSAKPNVIIDGYVDPSGG-NRFCLGALSNVHRTEQSERARLHIGKGVQLDLRGEGDVWLR 623
            |.|...|.  :|::||:.|||.. :|||||.||||:|....|..|.||||||.|...| |:|:..
Mouse   285 EAFHASST--SVLVDGFTDPSNNKSRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVG-GEVYAE 346

  Fly   624 CLSDNSVFVQSYYLDREAGRTPGDAVHKIYPAAC-IKVFDLRQCHQQMHSLATNAQAAAAAQAAA 687
            ||||:|:||||...:...|..| ..|.|| |::| :|:|:    :|:.            ||..|
Mouse   347 CLSDSSIFVQSRNCNFHHGFHP-TTVCKI-PSSCSLKIFN----NQEF------------AQLLA 393

  Fly   688 VAGVANQQMGGGGRSMTAAAGIGVDDLRRLCILRLSFVKGWGPDYPRQSIKETPCWIEVHLHRAL 752
                  |.:..|..:        |.:|.::|.:|:|||||||.:|.||.:..||||||:|||..|
Mouse   394 ------QSVNHGFEA--------VYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPL 444

  Fly   753 QLLDEVLHAM 762
            |.||:||..|
Mouse   445 QWLDKVLTQM 454

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Med	NP_524610.1	MH1_SMAD_4	42..166	CDD:199816	64/118 (54%)
		MH2_SMAD_4	543..760	CDD:199823	93/218 (43%)
Smad5	NP_001157513.1	MH1_SMAD_1_5_9	10..133	CDD:199814	64/118 (54%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	163..251		34/283 (12%)
		MH2_SMAD_1_5_9	265..465	CDD:199822	95/225 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3701
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810