DRSC/TRiP Functional Genomics Resources

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Protein Alignment Med and Smad4

DIOPT Version :9

Sequence 1:NP_524610.1 Gene:Med / 43725 FlyBaseID:FBgn0011655 Length:771 Species:Drosophila melanogaster
Sequence 2:NP_032566.2 Gene:Smad4 / 17128 MGIID:894293 Length:551 Species:Mus musculus


Alignment Length:753 Identity:381/753 - (50%)
Similarity:423/753 - (56%) Gaps:230/753 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    35 SNAPTSADACLSIVHSLMCHRQGGESEGFAKRAIESLVKKLKEKRDELDSLITAITTNGAHPSKC 99
            :|.|||.||||||||||||||||||||.||||||||||||||||:||||||||||||||||||||
Mouse     7 TNTPTSNDACLSIVHSLMCHRQGGESETFAKRAIESLVKKLKEKKDELDSLITAITTNGAHPSKC 71

  Fly   100 VTIQRTLDGRLQVAGRKGFPHVIYARIWRWPDLHKNELKHVKYCAFAFDLKCDSVCVNPYHYERV 164
            ||||||||||||||||||||||||||:|||||||||||||||||.:|||||||||||||||||||
Mouse    72 VTIQRTLDGRLQVAGRKGFPHVIYARLWRWPDLHKNELKHVKYCQYAFDLKCDSVCVNPYHYERV 136

  Fly   165 VSPGIDLSGLSLQS-GPSRLVKDEY----SAGPLVGSMDIDGNDIGTIQHHPTQMVGPGGYGYPQ 224
            ||||||||||:||| .||.||||||    ...|   |:..:|:.|.||||.|:.......|..|.
Mouse   137 VSPGIDLSGLTLQSNAPSMLVKDEYVHDFEGQP---SLPTEGHSIQTIQHPPSNRASTETYSAPA 198

  Fly   225 GPSEYVGDANPMSAMFPTGRTIPKIEPQDGVAGSRGSWMVPPPPRLGQPPQQQQQQPQQQTPQPT 289
                                                  ::.|                       
Mouse   199 --------------------------------------LLAP----------------------- 202

  Fly   290 QQQQAQSQAAAHSLPVPHGMPGMPGPMNPGPVMAPPPPPQQAQNPQGNGVHHTQANSPTDPASAL 354
                |:|.|.:.:     ..|.:|                              ..|.:.|||.|
Mouse   203 ----AESNATSTT-----NFPNIP------------------------------VASTSQPASIL 228

  Fly   355 AMQQQQQQQQQQQQQQQQQQQQSGGVPNGSVNAGGGAAAGGQYYGQPPPVSQMQGAGGGGTSVAP 419
            |                           ||.:.|....|.|...||                   
Mouse   229 A---------------------------GSHSEGLLQIASGPQPGQ------------------- 247

  Fly   420 SVHAQQNGYVSQPGSAGSAPVGGGGVFGTAQPTPQQPQQPPTGVQANTGSAGAQAGAGGGAAGTW 484
                ||||:.:||                                         |.....:..||
Mouse   248 ----QQNGFTAQP-----------------------------------------ATYHHNSTTTW 267

  Fly   485 TGPNTLTYTQSM----------QPPDPRSLPGGFWNSSLSGDLGSPQQTPPQQQQQQQQPRLLSR 539
            ||..|..||.::          .||.|.. ||.:|              |...:...|.|  :|.
Mouse   268 TGSRTAPYTPNLPHHQNGHLQHHPPMPPH-PGHYW--------------PVHNELAFQPP--ISN 315

  Fly   540 QPPPEYWCSIAYFELDTQVGETFKVPSAKPNVIIDGYVDPSGGNRFCLGALSNVHRTEQSERARL 604
            .|.|||||||||||:|.||||||||||:.|.|.:|||||||||:|||||.||||||||..|||||
Mouse   316 HPAPEYWCSIAYFEMDVQVGETFKVPSSCPVVTVDGYVDPSGGDRFCLGQLSNVHRTEAIERARL 380

  Fly   605 HIGKGVQLDLRGEGDVWLRCLSDNSVFVQSYYLDREAGRTPGDAVHKIYPAACIKVFDLRQCHQQ 669
            ||||||||:.:||||||:|||||::||||||||||||||.||||||||||:|.||||||||||:|
Mouse   381 HIGKGVQLECKGEGDVWVRCLSDHAVFVQSYYLDREAGRAPGDAVHKIYPSAYIKVFDLRQCHRQ 445

  Fly   670 MHSLATNAQAAAAAQAAAVAG-VANQQMGGG---GRSMTAAAGIGVDDLRRLCILRLSFVKGWGP 730
            |...|..|||||||||||||| :......||   ..|::|||||||||||||||||:||||||||
Mouse   446 MQQQAATAQAAAAAQAAAVAGNIPGPGSVGGIAPAISLSAAAGIGVDDLRRLCILRMSFVKGWGP 510

  Fly   731 DYPRQSIKETPCWIEVHLHRALQLLDEVLHAMPIDGPR 768
            |||||||||||||||:||||||||||||||.|||..|:
Mouse   511 DYPRQSIKETPCWIEIHLHRALQLLDEVLHTMPIADPQ 548

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MedNP_524610.1 MH1_SMAD_4 42..166 CDD:199816 118/123 (96%)
MH2_SMAD_4 543..760 CDD:199823 177/220 (80%)
Smad4NP_032566.2 Mediates interaction with ZBTB7A. /evidence=ECO:0000250|UniProtKB:Q13485 1..321 199/524 (38%)
MH1_SMAD_4 14..138 CDD:199816 118/123 (96%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 166..192 9/28 (32%)
SAD 274..319 13/61 (21%)
MH2_SMAD_4 319..540 CDD:199823 177/220 (80%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 344 1.000 Domainoid score I1054
eggNOG 1 0.900 - - E1_KOG3701
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H31310
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S5208
OMA 1 1.010 - - QHG48996
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0004851
OrthoInspector 1 1.000 - - oto94407
orthoMCL 1 0.900 - - OOG6_105347
Panther 1 1.100 - - LDO PTHR13703
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R5008
SonicParanoid 1 1.000 - - X3979
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1413.760

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