Protein Alignment Med and Smad1

DIOPT Version :9

• Sequence 1: NP_524610.1
• Gene: Med / 43725
• FlyBaseID: FBgn0011655
• Length: 771
• Species: Drosophila melanogaster
• Sequence 2: NP_032565.2
• Gene: Smad1 / 17125
• MGIID: 109452
• Length: 465
• Species: Mus musculus
• Alignment Length: 719
• Identity: 211/719 - (29%)
• Similarity: 278/719 - (38%)
• Gaps: 282/719 - (39%)

  Fly    48 VHSLMCHRQGGESEGFAKRAIESLVKKLKEKRDELDSLITAITTNGAHPSKCVTIQRTLDGRLQV 112
            |..|:..:||.|.|.:|::|:::||||||:|:..::.|..|::..| .||.||||.|:|||||||
Mouse    14 VKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALSCPG-QPSNCVTIPRSLDGRLQV 77

  Fly   113 AGRKGFPHVIYARIWRWPDLHK-NELKHVKYCAFAFDLKCDSVCVNPYHYERVVSPGIDLSGLSL 176
            :.|||.|||||.|:||||||.. :|||.::.|.|.|..|...||:|||||:||.||.:
Mouse    78 SHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSKQKEVCINPYHYKRVESPVL------- 135

  Fly   177 QSGPSRLVKDEYSAGPLVGSMDIDGNDIGTIQHHPTQMVGPGGYGYPQGPSEYVGDANPMSAMFP 241
               |..||.                      :|                 |||    ||..::..
Mouse   136 ---PPVLVP----------------------RH-----------------SEY----NPQHSLLA 154

  Fly   242 TGRTIPKIEPQDGVAGSRGSWMVPPPPRLGQPPQQQQQQPQQQT-PQPTQQQQAQSQAAAHSLPV 305
            ..|.:.:.||                           ..|...| |...||        .:|.|.
Mouse   155 QFRNLGQNEP---------------------------HMPLNATFPDSFQQ--------PNSHPF 184

  Fly   306 PHGMPGMPGPMNPGPVMAPPPPPQQAQNPQGNGVHHTQANSPTDPASALAMQQQQQQQQQQQQQQ 370
            ||. |....|.:||                  |...|..:|||.
Mouse   185 PHS-PNSSYPNSPG------------------GSSSTYPHSPTS--------------------- 209

  Fly   371 QQQQQQSGGVPNGSVNAGGGAAAGGQYYGQPPPVSQMQGAGGGGTSVAPSVHAQQNGYVSQPGSA 435
                                                                       |.|||.
Mouse   210 -----------------------------------------------------------SDPGSP 215

  Fly   436 GSAPVGGGGVFGTAQPTPQQPQQPPTGVQANTGSAGAQAGAGGGAAGTWTGPNTLTYTQSMQPPD 500
            ...|.          .||.....||....|..||....                   |..|.||.
Mouse   216 FQMPA----------DTPPPAYLPPEDPMAQDGSQPMD-------------------TNMMAPPL 251

  Fly   501 PRSLPGGFWNSSLSGDLGSPQQTPPQQQQQQQQPRLLSRQPPPEYWCSIAYFELDTQVGETFKVP 565
            |..:.        .||:    |....::              |::||||.|:||:.:|||.|...
Mouse   252 PAEIS--------RGDV----QAVAYEE--------------PKHWCSIVYYELNNRVGEAFHAS 290

  Fly   566 SAKPNVIIDGYVDPSGG-NRFCLGALSNVHRTEQSERARLHIGKGVQLDLRGEGDVWLRCLSDNS 629
            |.  :|::||:.|||.. ||||||.||||:|....|..|.||||||.|...| |:|:..||||:|
Mouse   291 ST--SVLVDGFTDPSNNKNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVG-GEVYAECLSDSS 352

  Fly   630 VFVQSYYLDREAGRTPGDAVHKIYPAAC-IKVFDLRQCHQQMHSLATNAQAAAAAQAAAVAGVAN 693
            :||||...:...|..| ..|.|| |:.| :|:|:    :|:.            ||..|
Mouse   353 IFVQSRNCNYHHGFHP-TTVCKI-PSGCSLKIFN----NQEF------------AQLLA------ 393

  Fly   694 QQMGGGGRSMTAAAGIGVDDLRRLCILRLSFVKGWGPDYPRQSIKETPCWIEVHLHRALQLLDEV 758
            |.:..|..:        |.:|.::|.:|:|||||||.:|.||.:..||||||:|||..||.||:|
Mouse   394 QSVNHGFET--------VYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKV 450

  Fly   759 LHAM 762
            |..|
Mouse   451 LTQM 454

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Med	NP_524610.1	MH1_SMAD_4	42..166	CDD:199816	63/118 (53%)
		MH2_SMAD_4	543..760	CDD:199823	94/218 (43%)
Smad1	NP_032565.2	MH1_SMAD_1_5_9	9..132	CDD:199814	63/118 (53%)
		PRK10263	<133..>244	CDD:236669	43/326 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	162..246		33/246 (13%)
		MH2_SMAD_1_5_9	265..465	CDD:199822	96/239 (40%)
		L3 loop. /evidence=ECO:0000250|UniProtKB:Q15797	418..428		6/9 (67%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3701
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810