Protein Alignment Med and Smox

DIOPT Version :10

• Sequence 1: NP_524610.1
• Gene: Med / 43725
• FlyBaseID: FBgn0288966
• Length: 771
• Species: Drosophila melanogaster
• Sequence 2: XP_318870.3
• Gene: Smox / 1279189
• VectorBaseID: AGAMI1_006596
• Length: 506
• Species: Anopheles gambiae
• Alignment Length: 765
• Identity: 216/765 - (28%)
• Similarity: 294/765 - (38%)
• Gaps: 289/765 - (37%)

  Fly    27 MVQMPPPPSNAPTSADACLSIVHSLMCHRQ---GGESEG-FAKRAIESLVKKLKEKRDELDSLIT 87
            |:...||             ||..|:..|:   ...:|| :.::.|:||.||:| |...|:.|..
Mosquito     1 MLPFTPP-------------IVKRLLGWRKVSPDDSAEGKWGEKVIKSLAKKMK-KSSALEELER 51

  Fly    88 AITTNGAHPSKCVTIQRTLD--GRLQVAGRKGFPHVIYARIWRWPDLHKN-ELKHVKYCAFAFDL 149
            |:|...:| :||:.|.|...  |...||.:||.||||..|:||||||:.: |||.:..|.:|:.|
Mosquito    52 ALTAQSSH-TKCIPISRNASAIGENGVALKKGLPHVICCRLWRWPDLNSHTELKPLDVCEYAYHL 115

  Fly   150 KCDSVCVNPYHYERVVSPGIDLSGLSLQSGPSRLVKDEYSAGPLVGSMDIDGNDIGTIQHHPTQM 214
            |.|.||:|||||.|                     .:.:|                  ||
Mosquito   116 KKDEVCINPYHYAR---------------------NESHS------------------QH----- 136

  Fly   215 VGPGGYGYPQGPSEYVGDANPMSAMFPTGRTIPKIEPQDGVAGSRGSWMVPPPPRLGQPPQQQQQ 279
                                                                        .||||
Mosquito   137 ------------------------------------------------------------SQQQQ 141

  Fly   280 QPQQQTPQPTQQQQAQSQAAAHSLPVPHGMPGMPGP----------MNPGPVMAPPPPPQQAQNP 334
            .||||  |.:||.|...     ::.||..:....|.          .|..||           |.
Mosquito   142 SPQQQ--QSSQQLQQPL-----TILVPKNLSNSQGENSVTYTLDDLSNTVPV-----------NT 188

  Fly   335 QGNGVHHTQANSPTDPASALAMQQQQQQQQ-----QQQQQQQQQQQQSGGVPNGSVNAGGGAAAG 394
            |.|.::.....|| .|:...:.|.||||.|     ||.||||||||.|......:.
Mosquito   189 QYNALNDNYVTSP-QPSQVTSRQLQQQQLQPNQLHQQLQQQQQQQQLSSPCYMEAT--------- 243

  Fly   395 GQYYGQPPPVSQMQGAGGGGTSVAPSVHAQQNGYVSQPGSAGSAPVGGGGVFGTAQPTPQQPQQP 459
               .||..|.:         |::..||..                    ||     |.....:.|
Mosquito   244 ---LGQQIPTN---------TTIMDSVSV--------------------GV-----PNIPNTETP 271

  Fly   460 PTGVQANTGSAGAQAGAGGGAAGTWTGPNTLTYTQSMQPPDPRSLPGGFWNSSLSGDLGSPQQTP 524
            |.|..:..|....|             .:.:|....|.|                    |...|.
Mosquito   272 PPGYMSEDGDPLDQ-------------NDNMTDLSRMSP--------------------SEMDTQ 303

  Fly   525 PQQQQQQQQPRLLSRQPPPEYWCSIAYFELDTQVGETFKVPSAKPNVIIDGYVDPSGGNRFCLGA 589
            |....:            |.:||||:|:||:.:|||||.  :::|::.:||:.|||...|||||.
Mosquito   304 PVMYHE------------PTFWCSISYYELNLRVGETFH--ASQPSITVDGFTDPSNSERFCLGL 354

  Fly   590 LSNVHRTEQSERARLHIGKGVQLDLRGEGDVWLRCLSDNSVFVQSYYLDREAGRTPGDAVHKIYP 654
            ||||:|.|..|:.|.||||||:|...| |:|:..||||:|:||||...::..|..|. .|.||.|
Mosquito   355 LSNVNRNEVVEQTRRHIGKGVRLYYIG-GEVFAECLSDSSIFVQSPNCNQRYGWHPA-TVCKIPP 417

  Fly   655 AACIKVFDLRQCHQQMHSLATNAQAAAAAQAAAVAGVANQQMGGGGRSMTAAAGI-GVDDLRRLC 718
            ...:|:|:    :|:..:|.                           |.:.:.|. .|..|.|:|
Mosquito   418 GCNLKIFN----NQEFATLL---------------------------SQSVSMGFEAVYQLTRMC 451

  Fly   719 ILRLSFVKGWGPDYPRQSIKETPCWIEVHLHRALQLLDEVLHAMPIDGPR 768
            .:|:|||||||.:|.||::..||||||:||:..||.||.||..|  ..||
Mosquito   452 TIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDRVLTQM--GSPR 499

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Med	NP_524610.1	MH1_SMAD_4	42..166	CDD:199816	54/130 (42%)
		MH2_SMAD_4	543..760	CDD:199823	91/217 (42%)
Smox	XP_318870.3	MH1	5..131	CDD:469592	56/161 (35%)
		MH2_SMAD_2_3	305..495	CDD:199826	92/236 (39%)