Protein Alignment Med and smad6a

DIOPT Version :10

• Sequence 1: NP_524610.1
• Gene: Med / 43725
• FlyBaseID: FBgn0288966
• Length: 771
• Species: Drosophila melanogaster
• Sequence 2: NP_001019981.2
• Gene: smad6a / 116992
• ZFINID: ZDB-GENE-011015-1
• Length: 456
• Species: Danio rerio
• Alignment Length: 700
• Identity: 121/700 - (17%)
• Similarity: 178/700 - (25%)
• Gaps: 367/700 - (52%)

  Fly    55 RQGGESEGFAKRAIESLVKKLKEKRDELDSLITAITTNGAHPSKCVTIQRTLDGRLQVAGRKGFP 119
            :.|..:|...|:...:.:||||:|  .||.|:.|:.:.|..||.||.:.:|   .:::.|....|
Zfish   120 KTGAVTEQELKKCTYAFLKKLKDK--SLDVLLEAVESQGGMPSGCVLVSQT---EVRIGGHLVSP 179

  Fly   120 HVIYARIWRWPDLHKNE-LKHVKYCAFAFDLKCDSVCVNPYHYERVVSPGIDLSGLSLQSGPSRL 183
            ..:..|::|||||..:. ||.:.:|.........::|.||:||.|:..|
Zfish   180 QYLLCRLFRWPDLRLSSLLKPLCHCQSFRAEDSQTLCCNPHHYSRLCGP---------------- 228

  Fly   184 VKDEYSAGPLVGSMDIDGNDIGTIQHHPTQMVGPGGYGYPQGPSEYVGDANPMSAMFPTGRTIPK 248
            |||:
Zfish   229 VKDD------------------------------------------------------------- 232

  Fly   249 IEPQDGVAGSRGSWMVPPPPRLGQPPQQQQQQPQQQTPQPTQQQQAQSQAAAHSLPVPHGMPGMP 313
                           .||||                              .:|..|:|...
Zfish   233 ---------------TPPPP------------------------------YSHLSPLPEHK---- 248

  Fly   314 GPMNPGPVMAPPPPPQQAQNPQGNGVHHTQANSPTDPASALAMQQQQQQQQQQQQQQQQQQQQSG 378
             |:|....|.|
Zfish   249 -PLNSSLPMLP------------------------------------------------------ 258

  Fly   379 GVPNGSVNAGGGAAAGGQYYGQPPPVSQMQGAGGGGTSVAPSVHAQQNGYVSQPGSAGSAPVGGG 443
                                                             |:
Zfish   259 -------------------------------------------------YI-------------- 260

  Fly   444 GVFGTAQPTPQQPQQPPTGVQANTGSAGAQAGAGGGAAGTWTGPNTLTYTQSMQPPDPRSLPGGF 508
                                     ...|...|||
Zfish   261 -------------------------ETEATRSAGG------------------------------ 270

  Fly   509 WNSSLSGDLGSPQQTPPQQQQQQQQPRLLSRQPPPEYWCSIAYFELDTQVGETFKVPSAKPNVII 573
                ||.|......:|....|              .:||::||:||.|:||..:.|..|..::
Zfish   271 ----LSQDYSDASMSPSSLAQ--------------NHWCNVAYWELRTRVGRLYPVHDASLSI-- 315

  Fly   574 DGYVDPSGGNRFCLGALSNVHRTEQSERARLHIGKGVQLDLRGEGDVWLRCLSDNSVFVQSYYLD 638
              :.|...|...|||.|....|:...:|.|..||.|:.|....:| ||....|.:.:||.|..|:
Zfish   316 --FYDLPQGTGLCLGLLPLSPRSTSVQRTRGKIGHGILLSKEPDG-VWAYNRSQHPIFVNSPTLE 377

  Fly   639 REAGRTPGDAVHKIYPAACIKVFDL-RQCHQQMHSLATNAQAAAAAQAAAVAGVANQQMGGGGRS 702
            .....:.  .|.::.|...|||||. :.|..|..|...:.:......:
Zfish   378 HHPYLSL--TVRRVMPGYSIKVFDYEKSCQMQPASHPVHPEGPYDPNS----------------- 423

  Fly   703 MTAAAGIGVDDLRRLCILRLSFVKGWGPDYPRQSIKETPCWIEVHL--HR 750
                             :|:||.|||||.|.||.|...|||:|:.|  ||
Zfish   424 -----------------VRISFAKGWGPCYSRQFITSCPCWLEILLNNHR 456

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Med	NP_524610.1	MH1_SMAD_4	42..166	CDD:199816	35/111 (32%)
		MH2_SMAD_4	543..760	CDD:199823	60/210 (29%)
smad6a	NP_001019981.2	MH1_SMAD_6	118..229	CDD:199817	36/129 (28%)
		MH2	281..454	CDD:469593	61/227 (27%)