Protein Alignment Med and smad10

DIOPT Version :10

• Sequence 1: NP_524610.1
• Gene: Med / 43725
• FlyBaseID: FBgn0288966
• Length: 771
• Species: Drosophila melanogaster
• Sequence 2: XP_031747717.1
• Gene: smad10 / 100188925
• XenbaseID: XB-GENE-5995152
• Length: 552
• Species: Xenopus tropicalis
• Alignment Length: 729
• Identity: 312/729 - (42%)
• Similarity: 363/729 - (49%)
• Gaps: 225/729 - (30%)

  Fly    58 GESEGFAKRAIESLVKKLKEKRDELDSLITAITTNGAHPSKCVTIQRTLDGRLQVAGRKGFPHVI 122
            |.|||     :.|.|.:....:....:|:.......:|...|..:...   .|.|||||||||||
 Frog    26 GLSEG-----VRSSVTRAYTLKKGYPALVVLQLPASSHRLYCPPVWSV---PLIVAGRKGFPHVI 82

  Fly   123 YARIWRWPDLHKNELKHVKYCAFAFDLKCDSVCVNPYHYERVVSPGIDLSGLSLQSGPSRLVKDE 187
            |||:|||||||||||||||:|.||||||.||||||||||||||||||.||..|..:.|.|.||:|
 Frog    83 YARLWRWPDLHKNELKHVKFCQFAFDLKYDSVCVNPYHYERVVSPGIGLSIPSTATTPCRSVKEE 147

  Fly   188 YSAGPLVGSMDIDGNDIGTIQHHPTQMVGPGGYGYPQGPSEYVGDANPMSAMFPTGRTIPKIEPQ 252
            |:                    |..:|                    ..|:..||.:.:|
 Frog   148 YA--------------------HECEM--------------------EASSCLPTSQELP----- 167

  Fly   253 DGVAGSRGSWMVPPPPRLGQPPQQQQQQPQQQTPQPTQQQQAQSQAAAH-SLPV-PHGMPGMP-G 314
                        |.......||..|.:..:|..|..|..:..|:..:.: ::|: |...||.| .
 Frog   168 ------------PAIKHASLPPMPQSEPYRQPLPPLTLPKSPQTAISMYPNMPLSPSVAPGCPLV 220

  Fly   315 PMN-PGPVMAPPPPPQQAQNPQGNGVHHTQANSPTDPASALAMQQQQQQQQQQQQQQQQQQQQSG 378
            |:: .|.:...|..|||..:              |.|.|
 Frog   221 PLHGEGLLQIAPSHPQQMVS--------------TSPPS-------------------------- 245

  Fly   379 GVPNGSVNAGGGAAAGGQYYGQPPPVSQMQGAGGGGTSVAPSVHAQQNGYVSQPGSAGSAPVGGG 443
                                                   .|..::|||||
 Frog   246 ---------------------------------------TPGQNSQQNGY--------------- 256

  Fly   444 GVFGTAQPTPQQPQQPPTGVQANTGSAGAQAGAGGGAAGTWTGPNTLTYTQSMQPPDPRSLPGGF 508
                     |..|:||                    ...:|||.:|..||.|         |||.
 Frog   257 ---------PSPPKQP--------------------FHASWTGSSTAVYTPS---------PGGQ 283

  Fly   509 WNSSLSGDLGSPQQTPP-----------QQQQQQQQPRLLSRQPPPEYWCSIAYFELDTQVGETF 562
            .|       |...|.||           |...|.|.|  :|..|.||:|||:||||:|.||||.|
 Frog   284 QN-------GRGNQQPPLHHPNHYWPLHQSSPQYQHP--VSNHPGPEFWCSVAYFEMDVQVGEIF 339

  Fly   563 KVPSAKPNVIIDGYVDPSGGNRFCLGALSNVHRTEQSERARLHIGKGVQLDLRGEGDVWLRCLSD 627
            ||||..|.|.:|||||||||:|||||.|||||||:.||||||||||||||:.|||||||:|||||
 Frog   340 KVPSNCPVVTVDGYVDPSGGDRFCLGQLSNVHRTDTSERARLHIGKGVQLECRGEGDVWMRCLSD 404

  Fly   628 NSVFVQSYYLDREAGRTPGDAVHKIYPAACIKVFDLRQCHQQMHSLATNAQAAAAAQAAAVAGVA 692
            ::||||||||||||||.||||||||||.|.||||||||||:||...|..||||||||||||||..
 Frog   405 HAVFVQSYYLDREAGRAPGDAVHKIYPGAYIKVFDLRQCHRQMQQQAATAQAAAAAQAAAVAGTI 469

  Fly   693 NQQMGGGG----RSMTAAAGIGVDDLRRLCILRLSFVKGWGPDYPRQSIKETPCWIEVHLHRALQ 753
            ......||    .|::||||||||||||||||||||||||||||||||||:||||||||||||||
 Frog   470 PGPGSVGGIAPAVSLSAAAGIGVDDLRRLCILRLSFVKGWGPDYPRQSIKQTPCWIEVHLHRALQ 534

  Fly   754 LLDEVLHAMPIDGP 767
            |||||||.:|:..|
 Frog   535 LLDEVLHTLPMADP 548

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Med	NP_524610.1	MH1_SMAD_4	42..166	CDD:199816	59/107 (55%)
		MH2_SMAD_4	543..760	CDD:199823	176/220 (80%)
smad10	XP_031747717.1	MH1	<70..126	CDD:469592	50/55 (91%)
		Atrophin-1	<161..>331	CDD:460830	64/327 (20%)
		MH2_SMAD_4	320..541	CDD:199823	176/220 (80%)