Protein Alignment Med and smad10b

DIOPT Version :10

• Sequence 1: NP_524610.1
• Gene: Med / 43725
• FlyBaseID: FBgn0288966
• Length: 771
• Species: Drosophila melanogaster
• Sequence 2: XP_001922725.2
• Gene: smad10b / 100151181
• ZFINID: ZDB-GENE-110408-38
• Length: 568
• Species: Danio rerio
• Alignment Length: 752
• Identity: 367/752 - (48%)
• Similarity: 419/752 - (55%)
• Gaps: 205/752 - (27%)

  Fly    36 NAPTSADACLSIVHSLMCHRQGGESEGFAKRAIESLVKKLKEKRDELDSLITAITTNGAHPSKCV 100
            |||:|.||||||||||||||||||:|.|||||||||||||||||||||||||||||||.||||||
Zfish     4 NAPSSNDACLSIVHSLMCHRQGGENESFAKRAIESLVKKLKEKRDELDSLITAITTNGVHPSKCV 68

  Fly   101 TIQRTLDGRLQVAGRKGFPHVIYARIWRWPDLHKNELKHVKYCAFAFDLKCDSVCVNPYHYERVV 165
            |||||||||||||||||||||||||:|||||||||||||||:|.:|||||.|:||||||||||||
Zfish    69 TIQRTLDGRLQVAGRKGFPHVIYARLWRWPDLHKNELKHVKFCQYAFDLKYDNVCVNPYHYERVV 133

  Fly   166 SPGIDLSGLSLQSGPSRLVKDEYSAGPLVGSMDIDGNDIGTIQ--HHPTQMVGPGGYGYPQGPSE 228
            ||||  .|.||.: ..|::|:|:    :...:.::|....|:|  |||              |..
Zfish   134 SPGI--VGFSLPN-TGRIIKEEH----IHDCIQLEGPSSMTLQHDHHP--------------PDH 177

  Fly   229 YVGDANPMSAMFPTGRTIPKIEPQDGVAGSRGSWMVPPPPRLGQPPQQQQQQPQQQTPQPTQQQQ 293
            |                                  .|.|.||     ..|:.||:.|...|.
Zfish   178 Y----------------------------------SPQPLRL-----MSQEPPQRTTSSVTL--- 200

  Fly   294 AQSQAAAHSLPVPHGMPGMPGPMNPGPVMAPPPPPQ---QAQNPQGNGVHHTQANSPTDPASALA 355
                           .|.:  |::|     ||..|:   ||:.|:|    ..|..||...|.:.:
Zfish   201 ---------------YPNL--PLSP-----PPSAPRLSIQAERPEG----LLQIASPAGRALSTS 239

  Fly   356 MQQQQQQQQQQQQQQQQQQQQSGGVPNGSVNAGGGAAAGGQYYGQPPPVSQMQGAGGGGTSVAPS 420
            ...............|...||                         |.|||.:.:....|....|
Zfish   240 TPPSTPTHSHPPTHSQPSSQQ-------------------------PSVSQSEYSNSKHTQTQSS 279

  Fly   421 VHAQQNGYVSQPGSAGSAPVGGGGVFGTAQPTPQQPQQPPTGVQANTGSAGAQAGAGGGAAGTWT 485
            .|..                                                          |||
Zfish   280 YHTT----------------------------------------------------------TWT 286

  Fly   486 GPNTLTYTQSMQPPDPRSLPGGFWNSSLSGDLGSPQQTPP--------QQQQQQQQPRLLSRQPP 542
            |.:|.:||    |..|:.          :|  .|.||.||        |.......|:.:|..|.
Zfish   287 GTSTASYT----PTGPQQ----------NG--RSHQQAPPPHTSHFWSQHHTPTSYPQPVSNHPG 335

  Fly   543 PEYWCSIAYFELDTQVGETFKVPSAKPNVIIDGYVDPSGGNRFCLGALSNVHRTEQSERARLHIG 607
            ||:||||:|||:|.||||.|||.:..|.|.:|||||||||:|||||.|||||||:.|||||||||
Zfish   336 PEFWCSISYFEMDVQVGEMFKVLANCPVVTVDGYVDPSGGDRFCLGQLSNVHRTDASERARLHIG 400

  Fly   608 KGVQLDLRGEGDVWLRCLSDNSVFVQSYYLDREAGRTPGDAVHKIYPAACIKVFDLRQCHQQMHS 672
            |||||:.|||||||:|||||::||||||||||||||.||||||||||.|.||||||||||:||..
Zfish   401 KGVQLECRGEGDVWMRCLSDHAVFVQSYYLDREAGRAPGDAVHKIYPGALIKVFDLRQCHRQMQQ 465

  Fly   673 LATNAQAAAAAQAAAVAGVANQQMGGGG----RSMTAAAGIGVDDLRRLCILRLSFVKGWGPDYP 733
            .|..||||||||||||||........||    .|::|||||||||||||||||||||||||||||
Zfish   466 QAATAQAAAAAQAAAVAGSIPGPGSVGGIAPAISLSAAAGIGVDDLRRLCILRLSFVKGWGPDYP 530

  Fly   734 RQSIKETPCWIEVHLHRALQLLDEVLHAMPIDGPRAA 770
            ||:||:||||:||||||||||||||||.||:..|..|
Zfish   531 RQTIKQTPCWVEVHLHRALQLLDEVLHTMPLADPGPA 567

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Med	NP_524610.1	MH1_SMAD_4	42..166	CDD:199816	114/123 (93%)
		MH2_SMAD_4	543..760	CDD:199823	172/220 (78%)
smad10b	XP_001922725.2	MH1_SMAD_4	10..134	CDD:199816	114/123 (93%)
		MH2_SMAD_4	336..557	CDD:199823	172/220 (78%)