DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Med and smad4

DIOPT Version :9

Sequence 1:	NP_524610.1	Gene:	Med / 43725	FlyBaseID:	FBgn0011655	Length:	771	Species:	Drosophila melanogaster
Sequence 2:	XP_002934485.1	Gene:	smad4 / 100038088	XenbaseID:	XB-GENE-485691	Length:	549	Species:	Xenopus tropicalis

Alignment Length:	753	Identity:	384/753 - (50%)
Similarity:	418/753 - (55%)	Gaps:	229/753 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 SNAPTSADACLSIVHSLMCHRQGGESEGFAKRAIESLVKKLKEKRDELDSLITAITTNGAHPSKC 99
            :|.|||.||||||||||||||||||||.||||||||||||||||:||||||||||||||||||||
Frog     4 TNTPTSNDACLSIVHSLMCHRQGGESETFAKRAIESLVKKLKEKKDELDSLITAITTNGAHPSKC 68

  Fly   100 VTIQRTLDGRLQVAGRKGFPHVIYARIWRWPDLHKNELKHVKYCAFAFDLKCDSVCVNPYHYERV 164
            ||||||||||||||||||||||||||:|||||||||||||||||.:|||||||||||||||||||
Frog    69 VTIQRTLDGRLQVAGRKGFPHVIYARLWRWPDLHKNELKHVKYCQYAFDLKCDSVCVNPYHYERV 133

  Fly   165 VSPGIDLSGLSLQSG--PSRLVKDEYSAGPLVGSMDI---DGNDIGTIQHHPTQMVGPGGYGYPQ 224
            ||||||||||:|||.  .|.||||||......|...|   ||:.|.||||.|:.......|..|
Frog   134 VSPGIDLSGLTLQSSAPSSLLVKDEYGHDYAEGQQSISAGDGHSIQTIQHPPSSRASTESYSNP- 197

  Fly   225 GPSEYVGDANPMSAMFPTGRTIPKIEPQDGVAGSRGSWMVPPPPRLGQPPQQQQQQPQQQTPQPT 289
                                                |.:.|..|               .||.||
Frog   198 ------------------------------------SMLAPSEP---------------STPNPT 211

  Fly   290 QQQQAQSQAAAHSLPVPHGMPGMPGPMNPGPVMAPPPPPQQAQNPQGNGVHHTQANSPTDPASAL 354
                     :..|:|||                                       |.:.|||.|
Frog   212 ---------SFSSIPVP---------------------------------------STSQPASLL 228

  Fly   355 AMQQQQQQQQQQQQQQQQQQQQSGGVPNGSVNAGGGAAAGGQYYGQPPPVSQMQGAGGGGTSVAP 419
            |.....                                                    |..|:||
Frog   229 AATHND----------------------------------------------------GLLSIAP 241

  Fly   420 SVHAQQNGYVSQPGSAGSAPVGGGGVFGTAQPTPQQPQQPPTGVQANTGSAGAQAGAGGGAAGTW 484
                                                  .||.|.|  .|..|..|.....:..||
Frog   242 --------------------------------------VPPQGTQ--NGFTGQPATYHHNSTTTW 266

  Fly   485 TGPNTLTYTQSM----------QPPDPRSLPGGFWNSSLSGDLGSPQQTPPQQQQQQQQPRLLSR 539
            ||..|..||.:|          .||.|.  ||.:|              |...:...|.|  :|.
Frog   267 TGSRTAAYTPNMSHHPNGHLQHHPPMPH--PGHYW--------------PVHNELAFQPP--ISN 313

  Fly   540 QPPPEYWCSIAYFELDTQVGETFKVPSAKPNVIIDGYVDPSGGNRFCLGALSNVHRTEQSERARL 604
            .|.|||||||||||:|.||||||||||:.|.|.:|||||||||:|||||.||||||||..|||||
Frog   314 HPAPEYWCSIAYFEMDVQVGETFKVPSSCPIVTVDGYVDPSGGDRFCLGQLSNVHRTEAIERARL 378

  Fly   605 HIGKGVQLDLRGEGDVWLRCLSDNSVFVQSYYLDREAGRTPGDAVHKIYPAACIKVFDLRQCHQQ 669
            ||||||||:.:||||||:|||||::||||||||||||||.||||||||||:|.||||||||||:|
Frog   379 HIGKGVQLECKGEGDVWVRCLSDHAVFVQSYYLDREAGRAPGDAVHKIYPSAYIKVFDLRQCHRQ 443

  Fly   670 MHSLATNAQAAAAAQAAAVAG-VANQQMGGG---GRSMTAAAGIGVDDLRRLCILRLSFVKGWGP 730
            |...|..|||||||||||||| :......||   ..|::|||||||||||||||||:||||||||
Frog   444 MQQQAATAQAAAAAQAAAVAGNIPGPGSVGGIAPAISLSAAAGIGVDDLRRLCILRMSFVKGWGP 508

  Fly   731 DYPRQSIKETPCWIEVHLHRALQLLDEVLHAMPIDGPR 768
            |||||||||||||||:||||||||||||||.|||..|:
Frog   509 DYPRQSIKETPCWIEIHLHRALQLLDEVLHTMPIADPQ 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Med	NP_524610.1	MH1_SMAD_4	42..166	CDD:199816	118/123 (96%)
Med	NP_524610.1	MH2_SMAD_4	543..760	CDD:199823	177/220 (80%)
smad4	XP_002934485.1	MH1_SMAD_4	11..135	CDD:199816	118/123 (96%)
smad4	XP_002934485.1	MH2_SMAD_4	317..538	CDD:199823	177/220 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	344	1.000	Domainoid score	I1052
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H31310
Inparanoid	1	1.050	399	1.000	Inparanoid score	I1886
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386709at33208
OrthoFinder	1	1.000	-	-		FOG0004851
OrthoInspector	1	1.000	-	-		otm49007
Panther	1	1.100	-	-	LDO	PTHR13703
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5008
SonicParanoid	1	1.000	-	-		X3979
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.190