DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CycG and CCNE2

DIOPT Version :9

Sequence 1:	NP_001263146.1	Gene:	CycG / 43724	FlyBaseID:	FBgn0039858	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_477097.1	Gene:	CCNE2 / 9134	HGNCID:	1590	Length:	404	Species:	Homo sapiens

Alignment Length:	159	Identity:	31/159 - (19%)
Similarity:	67/159 - (42%)	Gaps:	27/159 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   225 LKKLEDQLHALTSDELYETLKEYDVLQDKFHTVLLLPKESRREVTAGGRDGSAYVLRCLKMWYEL 289
            |||....:|    |:.:|.|  :..|:.:..::||                 .::|...:: |.|
Human   118 LKKESRYVH----DKHFEVL--HSDLEPQMRSILL-----------------DWLLEVCEV-YTL 158

  Fly   290 PSDVLFSAMSLVDRF-LDRMAVKPKHMACMSVASFHLAIKQLDLKPIPAEDLVTISQCGCTAGDL 353
            ..:..:.|....||| |.:..:....:..:.:.|..:|.|..::.....::...::...|:..|:
Human   159 HRETFYLAQDFFDRFMLTQKDINKNMLQLIGITSLFIASKLEEIYAPKLQEFAYVTDGACSEEDI 223

  Fly   354 ERMAGVIANKLGVQMGHAPITSVSYLRIY 382
            .||..:|...|..::  .|:|.:|:|.::
Human   224 LRMELIILKALKWEL--CPVTIISWLNLF 250

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycG	NP_001263146.1	CYCLIN	<287..365	CDD:294043	15/78 (19%)
CCNE2	NP_477097.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..44
		Cyclin_N	112..239	CDD:278560	27/146 (18%)
		Cyclin_C	241..361	CDD:281044	3/10 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5024
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810