DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CycG and CCNB1

DIOPT Version :9

Sequence 1:	NP_001263146.1	Gene:	CycG / 43724	FlyBaseID:	FBgn0039858	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_114172.1	Gene:	CCNB1 / 891	HGNCID:	1579	Length:	433	Species:	Homo sapiens

Alignment Length:	323	Identity:	66/323 - (20%)
Similarity:	123/323 - (38%)	Gaps:	61/323 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   183 TPGAAGLEYQKYEQQQQLEDLAESEAGAVGGASNNNGESSSSLKKLEDQLHALTSDELYETLKEY 247
            |.|.|..|          |||.::.:..:...::.:.|..:     :..|.:....::|..|::.
Human   132 TSGCAPAE----------EDLCQAFSDVILAVNDVDAEDGA-----DPNLCSEYVKDIYAYLRQL 181

  Fly   248 DVLQDKFHTVLLLPKESRREVTAGGRDGSAYVLRCLKMWYELPSDVLFSAMSLVDRFLDRMAVKP 312
            :..|......||     .||||...|......|..::|.:.|..:.::..:|::|||:....|..
Human   182 EEEQAVRPKYLL-----GREVTGNMRAILIDWLVQVQMKFRLLQETMYMTVSIIDRFMQNNCVPK 241

  Fly   313 KHMACMSVASFHLAIKQLDLKPIPAEDLVTISQCGCTAGDLERMAGVIANKLGVQMGHAPITSVS 377
            |.:..:.|.:..:|.|..::.|....|...::....|...:.:|...|...|...:|. |: .:.
Human   242 KMLQLVGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALNFGLGR-PL-PLH 304

  Fly   378 YLRIYYALFRNLAKEIGGDFFKFYQQLIKLEE---LENRLEILMCDVKTTVITPSTLALVLICLH 439
            :||        .|.:||.         :.:|:   .:..:|:.|.|.......||.:|....||.
Human   305 FLR--------RASKIGE---------VDVEQHTLAKYLMELTMLDYDMVHFPPSQIAAGAFCLA 352

  Fly   440 LDFHIKESYTRGSPELKHVFEY----ILFLQQYMRIPDRVFTCGFSIV---SGILSHYNGQNK 495
            |.......:|   |.|:|...|    :|.:.|::         ..::|   .|:..|...:||
Human   353 LKILDNGEWT---PTLQHYLSYTEESLLPVMQHL---------AKNVVMVNQGLTKHMTVKNK 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycG	NP_001263146.1	CYCLIN	<287..365	CDD:294043	15/77 (19%)
CCNB1	NP_114172.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	19..47
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	93..116
		Interaction with CDK2	169..177		1/7 (14%)
		Cyclin_N	173..298	CDD:278560	28/129 (22%)
		Interaction with CDK2	258..261		0/2 (0%)
		Cyclin_C	300..418	CDD:281044	28/134 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5024
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810