DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CycG and Ccnb3

DIOPT Version :9

Sequence 1:	NP_001263146.1	Gene:	CycG / 43724	FlyBaseID:	FBgn0039858	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_898836.2	Gene:	Ccnb3 / 209091	MGIID:	2183443	Length:	1396	Species:	Mus musculus

Alignment Length:	445	Identity:	79/445 - (17%)
Similarity:	154/445 - (34%)	Gaps:	106/445 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 EQLMQQRTSMSSSVMPG--LALPQDHQD---HPAALLNGPHNNNIGLAMDAHSINAILVDDEQPS 124
            |..:|::.|..:.|.|.  |||.::..:   :|...|:..|..:..:.    .|..:::.||:.:
Mouse   946 ESTLQEKPSTKTDVTPKELLALEENSSNKKANPMDSLSFDHKPDTEMG----EIARMVLTDEEYN 1006

  Fly   125 TSAQAAAAAAASAGGSAGAGSGSGLGGAIGGGKLANGINRNAEMPTDWMRIADEGR-------YG 182
            .........|.|.             |.|...:|:....:|.|.    .:|.||..       :.
Mouse  1007 IDTLYERVLALSQ-------------GLIAADQLSFTDLQNFEE----TKIVDEEEFFKSFLVFE 1054

  Fly   183 TPGAAGLEYQKYEQQQQLEDLAESEAGAVGGASNNN----------------------GESSSSL 225
            ...:..:....:|.:..........:.|.....|:|                      .:.|.||
Mouse  1055 NKNSPNMSSNAFESRTDNSSAIMPSSKAFNPVENSNPYVSSSKSFKSTLGAKETEITIQDDSDSL 1119

  Fly   226 KKLEDQ-----LHALTSDELYETLKEYDVLQDKFHTVLLLPK--ESRREVTAGGRDGSAYVLRCL 283
            :::|.:     |:.:.:.:::..|||   .::||    |:.|  :.:.|:|:..|       ..|
Mouse  1120 ERIEKEGQDPLLNTIYAKDVFNYLKE---REEKF----LVQKYMDGQMELTSDMR-------AIL 1170

  Fly   284 KMW-------YELPSDVLFSAMSLVDRFLDRMAVKPKHMACMSVASFHLAIKQLDLKPIPAEDLV 341
            ..|       :::..:.|:.|:.::|.:|.:...|..|:..:...::.:|.|..:..|....:.:
Mouse  1171 VDWLVEIQGSFQMTHETLYLAVKIMDLYLMKAQCKKNHLQLLGSTTYMIAAKFEESYPPSLSEFL 1235

  Fly   342 TISQCGCTAGDLERMAGVIANKLGVQMGHAPITSVSYLRIYYALFRNLAKEIGGDFFKFYQQLIK 406
            .|.:......|:..:...|...|...: :.| |:.::||.|.:......|.:....|.....|.:
Mouse  1236 FICEDMYEKSDMVSLESSILQTLNFDI-NIP-TAYNFLRRYASCIHASMKTLTLSRFICEMTLQE 1298

  Fly   407 LEELENRLEILMCDVKTTVITPSTLALVLICLHLDFHIKESYTRGSPELKHVFEY 461
            .|.:|.|              ||.||.....|.|       |.|.........||
Mouse  1299 YEYIEER--------------PSKLAAASFILAL-------YMRNLSNCVPTLEY 1332

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycG	NP_001263146.1	CYCLIN	<287..365	CDD:294043	12/77 (16%)
Ccnb3	NP_898836.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..64
		D-box	54..62
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	259..398
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	477..500
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	775..796
		COG5024	<1054..1372	CDD:227357	55/316 (17%)
		Cyclin_N	1138..1263	CDD:365896	25/139 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5024
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810