DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CycG and CCNI

DIOPT Version :9

Sequence 1:	NP_001263146.1	Gene:	CycG / 43724	FlyBaseID:	FBgn0039858	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_001335061.1	Gene:	CCNI / 10983	HGNCID:	1595	Length:	377	Species:	Homo sapiens

Alignment Length:	313	Identity:	69/313 - (22%)
Similarity:	129/313 - (41%)	Gaps:	62/313 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   264 SRREVTAGGRDGSAYVLRCLKMWYELPSDVLFSAMSLVDRFLDRMAVKPKHMACMSVASFHLAIK 328
            |.:.|:...||.....|..||..:.|..:....|.||:||||..:...||:::|::::.|.||.|
Human    36 SNQNVSPSQRDEVIQWLAKLKYQFNLYPETFALASSLLDRFLATVKAHPKYLSCIAISCFFLAAK 100

  Fly   329 QLDL-KPIPA-EDLVTISQCGCTAGDLERMAGVIANKLGVQMGHAPITSVSYLRIYYALFRNLAK 391
            .::. :.||. :.|...|.|||::.::.||..:|.:||...:..|  |.:.:|.|::|:..:...
Human   101 TVEEDERIPVLKVLARDSFCGCSSSEILRMERIILDKLNWDLHTA--TPLDFLHIFHAIAVSTRP 163

  Fly   392 EIGGDFFKFYQQLIKLEEL----------ENRLEILMCDVKTTVITPSTLALVLICLHLDFHIKE 446
            ::          |..|.:|          :..|..:.|: :......|.|||.::.|.::..|.:
Human   164 QL----------LFSLPKLSPSQHLAVLTKQLLHCMACN-QLLQFRGSMLALAMVSLEMEKLIPD 217

  Fly   447 --SYTRGSPELKHVFEYILFLQQYMRIPDRVFTCGFSIVSGILSHYNGQNKAPYKQRLVWKLSSR 509
              |.|            |..||:......::..|     ..:::|        :...|...|...
Human   218 WLSLT------------IELLQKAQMDSSQLIHC-----RELVAH--------HLSTLQSSLPLN 257

  Fly   510 TLRVLRPINRFSSDLPTIEEGIPNALDDGLRSRTESISSEEEEDWPTSPIIPI 562
            ::.|.||:..   .|.|.::|:       .|....|:...:.....:.|.:|:
Human   258 SVYVYRPLKH---TLVTCDKGV-------FRLHPSSVPGPDFSKDNSKPEVPV 300

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycG	NP_001263146.1	CYCLIN	<287..365	CDD:294043	26/79 (33%)
CCNI	NP_001335061.1	Cyclin_N	34..142	CDD:365896	34/105 (32%)
CCNI	NP_001335061.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	357..377
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	69	1.000	Domainoid score	I9622
eggNOG	1	0.900	-	-		E1_COG5024
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm40801
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	5	4.770