DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RpL6 and RPL6A

DIOPT Version :9

Sequence 1:	NP_651876.1	Gene:	RpL6 / 43723	FlyBaseID:	FBgn0039857	Length:	262	Species:	Drosophila melanogaster
Sequence 2:	NP_013638.1	Gene:	RPL6A / 854902	SGDID:	S000004538	Length:	176	Species:	Saccharomyces cerevisiae

Alignment Length:	189	Identity:	80/189 - (42%)
Similarity:	106/189 - (56%)	Gaps:	24/189 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 KKSKASYPT-------KTFVKKRPSKANFSEHKRNTRRNLTPGTVLILLAGRHQGKRVVLLKVLA 139
            :|:...||:       ||....||.|         .|.:|.|||||||||||.:|||||.||.|.
Yeast     4 QKAPKWYPSEDVAALKKTRKAARPQK---------LRASLVPGTVLILLAGRFRGKRVVYLKHLE 59

  Fly   140 SGLLLVTGPFALNSCPLRRVSQRYVIGTSSKVDLGAFKVPEHLNDAYFRRLK-AKKDKKTGEADI 203
            ...||::|||.:|..|||||:.||||.||:||.:....| |..|..||.:.| .||:||  ||::
Yeast    60 DNTLLISGPFKVNGVPLRRVNARYVIATSTKVSVEGVNV-EKFNVEYFAKEKLTKKEKK--EANL 121

  Fly   204 FAAKKERFVPNEQRKKDQKEVDAALLKVIKAHPEGKFFAKYLQNMFALHSSQYPHRMRF 262
            |..::.:.:..| |.:|||.||.||:..||..|   ...:||...|:|.:...||.::|
Yeast   122 FPEQQNKEIKAE-RVEDQKVVDKALIAEIKKTP---LLKQYLSASFSLKNGDKPHMLKF 176

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RpL6	NP_651876.1	Ribosomal_L6e_N	<23..>51	CDD:281813
		KOW_RPL6	106..262	CDD:240520	71/156 (46%)
		RPL14A	111..234	CDD:225074	63/123 (51%)
RPL6A	NP_013638.1	KOW_RPL6	26..176	CDD:240520	74/165 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157341314
Domainoid	1	1.000	68	1.000	Domainoid score	I2326
eggNOG	1	0.900	-	-		E1_COG2163
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	120	1.000	Inparanoid score	I1314
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53785
OrthoFinder	1	1.000	-	-		FOG0001826
OrthoInspector	1	1.000	-	-		otm46919
orthoMCL	1	0.900	-	-		OOG6_101188
Panther	1	1.100	-	-	O	PTHR10715
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1143
SonicParanoid	1	1.000	-	-		X1520
TreeFam	1	0.960	-	-
	14	13.790