DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rod and Kntc1

DIOPT Version :9

Sequence 1:	NP_476705.1	Gene:	rod / 43719	FlyBaseID:	FBgn0003268	Length:	2089	Species:	Drosophila melanogaster
Sequence 2:	XP_008767450.1	Gene:	Kntc1 / 304477	RGDID:	1307905	Length:	2205	Species:	Rattus norvegicus

Alignment Length:	2402	Identity:	506/2402 - (21%)
Similarity:	922/2402 - (38%)	Gaps:	577/2402 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MWSNFEASSLED------------ETISNIFSSRGIFQISSEEEVNKYPDVMASVQCGKMVIGID 53
            ||:|.|..:.:|            |:::.::....:.:||| |:.:..|.:.|.......:|..|
  Rat     1 MWNNIELLTSDDTGSGFLNVGSRKESVTALYQVDLLGKISS-EKTSLSPKIQACSLSDGFIIVAD 64

  Fly    54 KSLLLLEDELVAKCSFLAFGAAIEAIAISSSGNLIVCGLSDGEVHGVFIKG-LLLFSVAV--NLE 115
            :|::||:....:...||.|...::.:.:...|..:..|...|..|.:::.. ..||:.|.  ..|
  Rat    65 QSVILLDSTCRSLQLFLIFDTDVDVVGLCPEGKFLFVGERSGNFHLIYVTSKRTLFTKAFVEKAE 129

  Fly   116 DVSLTGGTFRSI-----HQLDQRFY--FTCKNGSIY----SLSDIDETCLETLGNMSLNENETIA 169
            |..    |:||:     ...:..:|  ....||..|    .||.|::..          ||..:.
  Rat   130 DER----TYRSLVIEKDGSNEGTYYMLLLTNNGFFYITNLQLSQIEQAI----------ENTDLD 180

  Fly   170 CEKALLEDVTIQRLSKGRSSCSVDCAVLLKRLLTGNISAENNQDD-----LEAQPG------LVI 223
            ..|.|          :|:..||.             ||.|:....     |.:|.|      .||
  Rat   181 SAKKL----------QGQFKCSF-------------ISTESYHSSGCLNLLASQSGKFANETSVI 222

  Fly   224 TGDQSTMNFRNAANDVTRINLPAQYGSLKQI-----------FNLEHYIIALTDSGHLVEIC-PY 276
            .|...:..|.....|.|:.::     |||..           |.|...::.:.|:.:::.:. .|
  Rat   223 IGGTGSCAFSKWEPDSTKKDM-----SLKNFVDTDIIRGAKSFQLIDNLLFVLDTDNVLSLWDAY 282

  Fly   277 TRTVYMCQTTQQKNLLIEDLLVMECSED----------NIELLVLTKSTAEG-RFIKIVEYPTLN 330
            |.|    ......:|.||..|:...::.          |::|:.||.:|.|. |.:.|...||:.
  Rat   283 TLT----PVWNWPSLPIEQFLLTTEADSPSSVTWQGITNLKLVTLTATTKEKMRNLIIYSLPTME 343

  Fly   331 VKNEVEVPDHAWLVRQPKCAVNLYYLAAKEVNQSSI----PSVVEMMLVSETDPSDRFKKLICKG 391
            :...:||...:.||:.......:|.|.....|..::    .|.:|:..::|..|.:|..:|:.|.
  Rat   344 ILYSLEVSSVSSLVQTGISTDTIYLLEGVHKNDPNLCEDSVSNLELRYLTEVLPENRLSRLLHKH 408

  Fly   392 RLEEAEEFGKQFELCLQPIYEAKAKRILVELCNSNSQNVDTKFQDLL----QLLSQVESKAFIKS 452
            |..:||.|..||.|.::.:|:.|:..||.:|...:.::..:::|.|:    :.|.:::...|:
  Rat   409 RFADAESFAIQFGLDVELVYKVKSNDILEKLALISDKSEQSEWQQLVDEAKENLCKIQDDDFV-- 471

  Fly   453 HRMIN--LNSRHI----LERYLHEVKKRLTFEDD------EEDMLEIDEQLHRLKTL-AIIDPYE 504
               :|  |.::.:    .:..|...|.||..::|      .:|.||:.:...:|.|. ....|.:
  Rat   472 ---VNFCLKAQWVTYETTQEMLSYAKTRLMKKEDRTLPACSDDFLEVLKAHAKLTTFYGAFGPEK 533

  Fly   505 -CNTDWQKFI-YDNNLVRMVKSLFNTDMPTACLIWRRHSSSILPLLNEDELRTLLGFIPSNTKPF 567
             ..:.|.:|: .:::|..:...|...:...|..:|.||.:......:...|..||..|.:.....
  Rat   534 FSGSAWVEFLNNEDDLKDIFVQLSEGNFDCAQYLWLRHRADFESKFDVKMLENLLNSISTQIPVE 598

  Fly   568 NVVQWLR-QFIPMVSNTHPSIMPFITDWSIEMTRNLQYS--PHWPDIGLEFCTKILDIFEEIQFT 629
            .:..|.: ..||.|....|.....:..|..:.:|||:.:  .:||:.||:.........:..:|.
  Rat   599 KLCSWFKNDVIPFVRRIVPEGQNILAKWLEQASRNLELTDKANWPENGLQLAEVFFTAEKTDKFG 663

  Fly   630 YS---------DVRRQQERNVGKLRDLVNALQDLSVLKTNYNMGFTLDNYMQDSIDATALSILQH 685
            :|         |.:..:|  |.:||.||:.||:|.:|...||....|..:.:::.......:...
  Rat   664 FSSSWHWISLKDYQNTEE--VQQLRTLVSKLQELIILHRKYNCRLALSEFEKENATTVVFRMFDR 726

  Fly   686 VQLDKL-QRLVKNFMYPIFQEKGRQPLDVIKQYISQLVASRLSSSS-------WLDRAMACIELL 742
            |...:| ..:::.|:....:|:..|..:::..||..|: .|.||.|       |..:|||.|..|
  Rat   727 VSAPELIPSVLEKFVRVYIREQNLQEEELLLLYIEDLL-KRCSSKSMTLFDTAWEAKAMAVIRCL 790

  Fly   743 HNEDSRLECALSVLQNAPVPWPDTLAPLIRLRAS-THPLAVKINAEYEIQVIKIMKVKYGWPADS 806
            .:.|...:..|.::..|.|||...:..|:|.... .||....:...|.:..:|.:...||    .
  Rat   791 SDTDLIFDAVLKIMYKAVVPWSAAVEQLVRQHLEMDHPKVKLLQESYRLMEMKKLLRGYG----I 851

  Fly   807 SDIN-LELFMMRIV----KLNLPDMLDDISALTKAAPELSTSANFNC-CYQMARRGQVEMAYEFF 865
            .::| |...:||:|    |.::|..|:|...:.:.. .||....::. ...:..|.|.|......
  Rat   852 REVNLLNKEIMRVVRYILKQDIPSSLEDALKVAQGY-RLSDDEIYSLRVIDLIDRDQGEDCLLLL 915

  Fly   866 KKLNGEKNSKSAKEVVEIMANI-LENSSSASFES-------------------DIK--------- 901
            :.|...:..|:|:.|: |.|.: |:.....|.|.                   ||:
  Rat   916 RSLPPSEAEKTAERVI-IWARLALQEEPDGSEEDKAWRISVAKTSMDILKILCDIQKDNLQKKDD 979

  Fly   902 VQEHL-------NVLELFKLFLPHVESVYERRYLV---------------IKHRFR-----LRKF 939
            .:|.|       ::.|.|::|||..:  |....||               .:|:||     ....
  Rat   980 AEEFLKRFKMVASLQENFEVFLPFED--YSDTGLVAGLREQYIKAQENAQAEHKFRGPPGPTPAM 1042

  Fly   940 GILLSCSSELIPLHRRHCLLDEAIERIIERAQATLNVSAFIASEISELCTALGLPKVFGLHR--- 1001
            |...|..|:   |||:..:|..:.:.:    :|.:.:.|....::     |:.|.|...|.:
  Rat  1043 GTNASVKSK---LHRQALVLQVSTQEL----EAEMALRALKDGKV-----AVALSKCRDLLKHYC 1095

  Fly  1002 ----------ICQRIGCLPLSCALAYHVVSFVDCVPANAGEFVNLALEL---------------L 1041
                      :||::      |    |:::  |.||..|...:||..|:               |
  Rat  1096 NADTGRLLFVVCQKL------C----HMLA--DDVPMVAPVGLNLPSEIHDLTCHAVTICSPDFL 1148

  Fly  1042 VQQIESAKGKNQETASSLQLINE-----------------NDPL------SFY------------ 1071
            :..:|.:|    .|.::::|..:                 .||.      .|:
  Rat  1149 LDVLELSK----YTLTAVELCRQCQMDDCGILMKAAVGTHKDPYEEWSYSDFFSEDGIVLESQVV 1209

  Fly  1072 --LAYELLTSAL-LHESSRRHDLVELIKYIRVAVIHYPLDAIKSHYDGKEQAVNEHICRALDGIS 1133
              :.|||::|.: |.|..||                 |||:|...|           |...:|
  Rat  1210 LPVIYELISSVVPLAEGKRR-----------------PLDSISLPY-----------CSTSEG-- 1244

  Fly  1134 VALGETTINFSCALNGSFDVKTLTVPTTTKKRYSVSMFDEVEVQPIQQQPQKKSVGGRMAIVKFL 1198
                                :.|.:|..:    |:|..    ::.:|:..|.: :..|..:..|.
  Rat  1245 --------------------ENLILPLVS----SISAL----LRNLQESSQWE-LALRFVVASFG 1280

  Fly  1199 ARTLLLMVIETEPNNSLLMQVRNE-LPENTKADVESACADFFLSLEHLTKVKEHDAWYVM-SQYL 1261
            .      .::...:|.:.|.:..: |.::|.|.          |.:.:.::||....::. |...
  Rat  1281 T------CLQHSVSNVMSMSLSEKLLGKSTLAS----------SRQIIMELKEKSIAFIRGSATT 1329

  Fly  1262 LDFQKQNCRTKRIINEGFITLQLRRIFRNAMGSKDV-------------NFIELFTMLVVDSEAL 1313
            |..:..|||        .:.|.|...:...:..|||             |:.::..:.:|.|.
  Rat  1330 LLHKVFNCR--------LVDLDLALAYCTLLPQKDVFENLWKFIDKAWQNYDKILALSLVGSR-- 1384

  Fly  1314 ALLEKLSVEVKTDLQKINFLTLSAMYHEHIEDLDSVHMIRTKRLKLFYYLEFCQQDHRIKGKFNA 1378
              |..|..:|:|.|:          :||  ..:|:...||..:|.:.:...|.|       .|.:
  Rat  1385 --LANLYQDVETGLR----------FHE--LSIDAKWGIRLGKLGISFQPAFRQ-------NFLS 1428

  Fly  1379 DMDNIEDLLKEFHNKQLDVQLLERMSKDFGFDYQ---KILITQILSILSAQELRFEVKRDTFGDE 1440
            ..|.|:.|:   :|..:|..|:......|..|..   ::.|..:|...::|....:....| ..:
  Rat  1429 KKDLIKALV---NNIDMDTSLILEYCSTFQLDSDAALRLFIETLLRNTTSQSQGGDAPEPT-QHQ 1489

  Fly  1441 ELVMLSSAQEMRDMCQPYINEINNVELFTSKLKHFIEDINIYFYELYMCVINILMYFDSAPKEME 1505
            ...:|..|.||    .|.:....::.:   .|...:..::.|.||:...|:.::    ....|..
  Rat  1490 HSKLLQKATEM----VPLLKSTKDLVI---SLTEILYKLDPYDYEMIEVVLKVI----EQANEKI 1543

  Fly  1506 IWMNI---LHFLRHKMITRRRNRPGQVETDTWLKSQRENGVMPKISRYRLPFKPIV---EQPLKD 1564
            ..:||   |:.|||....||.:.|..:|....|:...   .:|..::.||||..|:   .|....
  Rat  1544 TTVNINQALNLLRHLKSYRRMSPPVDLEYQYMLEHLI---TLPPAAQTRLPFHLILFGTAQNFWK 1605

  Fly  1565 ILDSELNVDNCQSWFPLIQMYTALKGSKDSSQNCDYFCMSAVKN------------SISEYKSKN 1617
            ||.|||:.::         :.|.|..||....:.|...:|..|:            |.....|..
  Rat  1606 ILSSELSEES---------LPTLLLISKLMKFSLDTLYVSTAKHVFEKNLKPKLLKSAQARSSVM 1661

  Fly  1618 DSESWSLHPTNNAFLQSILRLVEKVNNPNKAFLILYFVSNYARDGADQVEASYECWKFVKEKGHL 1682
            ..|...|..|..::|.||:       ||..|..|...::....:|..::.:...| .::.|: .|
  Rat  1662 SKEVDKLVQTLESYLLSIV-------NPEWAVAIAISLTQEIPEGPFKMTSLKFC-LYLAER-WL 1717

  Fly  1683 ITDPKSREQVAKVKR-------RYPIQKTQHLLYVYGLTDEKLLRQVENPTELIQALYHH----- 1735
            ...|...|...|||.       ::.:..|:.:|..:.|.|::.||.|..|..||.:||.|
  Rat  1718 QNIPPQDETCEKVKALQKKLYLQFRLSGTEAVLIAHKLNDQEYLRVVGKPAHLIVSLYEHPSISE 1782

  Fly  1736 ELILKSSK--VDINALVAEIAKLHDLCLATIQYRLLQKWLALTMESAGDGTILEETFMEEQNWPE 1798
            .|...|.|  .||:|...|||:::::.|..|...||:|||.                      |.
  Rat  1783 RLCTTSGKDYPDIHAAAKEIAEVNEINLEKIWDMLLEKWLC----------------------PS 1825

  Fly  1799 QANGAESSNSQDASEN--VNRAFYILSSWPKAEAVKFLVGLIFKGGSVNTST----------QLQ 1851
            .|.|.::|...:..|:  ::|..|:|.:.|    :.:...::|...:..|||          :.:
  Rat  1826 TAPGEKASEFFELEEDEVLHRVVYLLQARP----IDYSSRMLFVFATSATSTLGIRQLTFAHRAR 1886

  Fly  1852 MYECYSKLNDGS--NSFTNTISQRQFISIKCVHEL---KALGYKSNLEKFSDDHCN--KIDILKM 1909
            ..:|...|.|..  .|.....::.....:||:..|   :.|......|.|    ||  |..::|.
  Rat  1887 ALQCLLYLADKETIESLFKKPTEEMKSYLKCITFLASFETLNIPITYELF----CNSPKEGMIKG 1947

  Fly  1910 IWQRNAQNPLSLEVMANICLGFDIHLPQIWNGILKRMVMFHMVRELNALLDVLSCRPHLLHLDGL 1974
            :|:.::..|:::.::|.:||.:.|:..|:|||:|::::.|:|:..|..:|..:|....|..:...
  Rat  1948 LWKNHSHEPMAVRLVAELCLEYKIYDLQLWNGLLQKLLGFNMIPYLRKVLSCISSVHSLWQVPYF 2012

  Fly  1975 AQAWDYVLCHPLQNA-VELRSFKQEEVLHKTLLRLQGCPVVHALNLLQFAQLCIVVHRPHMAASL 2038
            ::||..|:..||.:| ..||..:..:.. ::|:.:..|||...|:::..|:..:.:..|..|.:.
  Rat  2013 SKAWQRVIQIPLLSASCPLRPSQLADCC-ESLVAILECPVSDDLDMMGVAKQYVQLELPAFALTC 2076

  Fly  2039 LSFCQSSEQR-QKIKKMIHSHPVENLRQQILDLEDAG--------ILPVVLNFAL--KELNL 2089
            |:....||:| |:||..::|...:.:.||:.:..:||        |..:|||..:  ||..:
  Rat  2077 LTLMPHSEKRHQQIKNFLNSCDAQIILQQLEEHMNAGQLAGLSQQIRSLVLNHVVNKKEFGI 2138

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rod	NP_476705.1	Rod_C	1544..2082	CDD:287465	144/595 (24%)
Kntc1	XP_008767450.1	Rod_C	1582..2125	CDD:287465	142/591 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166354134
Domainoid	1	1.000	109	1.000	Domainoid score	I6277
eggNOG	1	0.900	-	-		E1_KOG4256
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	221	1.000	Inparanoid score	I3466
OMA	1	1.010	-	-		QHG52014
OrthoDB	1	1.010	-	-		D122381at2759
OrthoFinder	1	1.000	-	-		FOG0007375
OrthoInspector	1	1.000	-	-		oto98280
orthoMCL	1	0.900	-	-		OOG6_106565
Panther	1	1.100	-	-	LDO	PTHR15688
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6266
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.900