DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rod and Kntc1

DIOPT Version :9

Sequence 1:	NP_476705.1	Gene:	rod / 43719	FlyBaseID:	FBgn0003268	Length:	2089	Species:	Drosophila melanogaster
Sequence 2:	NP_001035886.1	Gene:	Kntc1 / 208628	MGIID:	2673709	Length:	2207	Species:	Mus musculus

Alignment Length:	2403	Identity:	504/2403 - (20%)
Similarity:	925/2403 - (38%)	Gaps:	578/2403 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MWSNFEASSLED------------ETISNIFSSRGIFQISSEEEVNKYPDVMASVQCGKMVIGID 53
            ||:|.|..:.:|            |.::.::.:..:.:||| |:.:..|.:.|.......:|..|
Mouse     1 MWNNIELLTSDDTGSGCLSVGSRKENVTALYQADLLGKISS-EKTSLSPKIQAFSLSHGFIIVAD 64

  Fly    54 KSLLLLEDELVAKCSFLAFGAAIEAIAISSSGNLIVCGLSDGEVHGVFIKG-LLLFSVAVNLEDV 117
            :|::||:....:...||.|...::.:.:...|..:..|...|..|.:::.. ..||:.|...:.:
Mouse    65 QSVILLDSICRSLQLFLIFDTDVDVVGLCQEGKFLFVGERSGNFHLIYVTSKQTLFTKAFVEKAL 129

  Fly   118 SLTGGTFRSI-----HQLDQRFY--FTCKNGSIY----SLSDIDETCLETLGNMSLNENETIACE 171
            ..:..|:|::     ...:..:|  ....||..|    .||.|::..          ||..:...
Mouse   130 DESQRTYRNLIIEKDGSNEGTYYMLLLTNNGFFYITNLQLSQIEQAI----------ENTDLDSA 184

  Fly   172 KALLEDVTIQRLSKGRSSCSVDCAVLLKRLLTGNISAEN---------NQDDLEAQPGLVITGDQ 227
            |.|          :|:..||.             ||.||         :|....|....||.|..
Mouse   185 KKL----------QGQFKCSF-------------ISTENYHSCLSLVASQSGTFASKTSVIIGGT 226

  Fly   228 STMNFRNAANDVTRINLPAQYGSLKQI-----------FNLEHYIIALTDSGHLVEIC-PYTRTV 280
            .:..|.....|.|:..:     |||..           |.|...::.:.|:.:::.:. .||.|
Mouse   227 GSCAFSKWEPDSTKKEM-----SLKNFVGTDIIKGAKSFQLIDNLLFVLDTDNVLSLWDAYTLT- 285

  Fly   281 YMCQTTQQKNLLIEDLLVMECSED----------NIELLVLTKSTAEGRFIKIVEY--PTLNVKN 333
               ......:|.:|..::...::.          |::|:.|| :||:.:...::.|  |::....
Mouse   286 ---PVWNWPSLPVEQFVLTTEADSPSSVTWQGITNLKLVTLT-ATAKEKMRSLIIYSLPSMETLY 346

  Fly   334 EVEVPDHAWLVRQPKCAVNLYYLAAKEVNQSSI--PSVVEMML--VSETDPSDRFKKLICKGRLE 394
            .:||...:.||:.......:|.|.....|..::  .||.:::|  ::|..|.:|..:|:.|.|..
Mouse   347 SLEVSSVSSLVQTGISTDTIYLLEGIHKNDPNLCEDSVSDLVLRYLTEVLPENRLSRLLHKHRFA 411

  Fly   395 EAEEFGKQFELCLQPIYEAKAKRILVELC-NSNSQNVDTKFQDLL----QLLSQVESKAFIKSHR 454
            |||.|..||.|.::.:|:.|:..:|.:|. .|:.::..:|:|.|:    :.|.:::...|:
Mouse   412 EAESFAIQFGLDVELVYKVKSNDMLEKLALISSDKSEQSKWQQLVDEAKENLCKIQDDDFV---- 472

  Fly   455 MIN--LNSRHI----LERYLHEVKKRLTFEDDEEDMLEIDEQLHRLKTLAIIDPYE--------C 505
             :|  |.::.:    .:..|...|.||..::|.......|..:..||..|.:..:.        .
Mouse   473 -VNFCLKAQWVTYETTQEMLSYAKTRLMKKEDRALPASSDAFMEVLKAHAKLTTFYGAFGPEKFS 536

  Fly   506 NTDWQKFIYDNNLVRMV-KSLFNTDMPTACLIWRRHSSSILPLLNEDELRTLLGFIPSNTKPFNV 569
            .:.|.:|:.:.:.:|.| ..|...:...|..:|.||.:......:...|..||..|.:.....|:
Mouse   537 GSSWIEFLNNEDDLRDVFLQLSEGNFACAQYLWLRHRADFESKFDVKMLENLLNSISTQFPLENL 601

  Fly   570 VQWLR-QFIPMVSNTHPSIMPFITDWSIEMTRNLQYS--PHWPDIGLEFCTKILDIFEEIQFTYS 631
            ..|.: :.||.|....|.....:..|..:.:|||:.:  .:||:.||:..        |:.||..
Mouse   602 CSWFKNEVIPFVRRIVPEGQNILAKWLEQASRNLELTDKANWPENGLQLA--------EVFFTAE 658

  Fly   632 DVRR--------------QQERNVGKLRDLVNALQDLSVLKTNYNMGFTLDNYMQDSIDATALSI 682
            ...|              |....|.:||.||:.|::|.:|...||....|.::.:::.......:
Mouse   659 KTDRFGFASSWHWISLDYQNTEEVRQLRTLVSKLRELIILHRKYNCKLALSDFEKENATTVVFRM 723

  Fly   683 LQHVQLDK-----LQRLVKNFMYPIFQEKGRQPLDVIKQYISQLVASRLSSSS-------WLDRA 735
            ...|...:     |::.|:.::    :|:..|..:::..||..|: .|.||.|       |..:|
Mouse   724 FDRVSAPELIPSVLEKSVRVYI----REQNLQEEELLLLYIEDLL-KRCSSKSMTLFDTAWEAKA 783

  Fly   736 MACIELLHNEDSRLECALSVLQNAPVPWPDTLAPLIRLRAS-THPLAVKINAEYEIQVIK----- 794
            ||.|..|.:.|...:..|.::..|.|||...:..|::.... .||....:...|::..:|
Mouse   784 MAVIRCLSDTDLIFDAVLKIMYKAVVPWSAAVEQLVKQHLEMDHPKVKLLQESYKLMEMKKLLRG 848

  Fly   795 ------------IMKV-----KYGWPADSSDI----------NLELFMMRIVKLNLPDMLD---- 828
                        ||:|     |...|:...|.          :.|::.:||:     |::|
Mouse   849 YGIREVNLLNKEIMRVIRYILKQDIPSSLEDALKVAQGYRLSDDEIYSLRII-----DLIDREQG 908

  Fly   829 -DISALTKAAPELSTSANFNCCYQMARRGQVEMAYEFFKKLNGEKN--------SKSAKEVVEIM 884
             |...|.|:.|.....       :.|.|..:.......::.:|.:.        :|::.::::|:
Mouse   909 GDCLLLLKSLPAAEAE-------KTAERVIIWARLALQEEPDGSEEDKAWRISVAKTSVDILKIL 966

  Fly   885 ANILENSSSASFESD---IKVQEHLNVLELFKLFLPHVESVYERRYLV---------------IK 931
            .:|.:::.....||:   .:.|...::.|.|::|||..:  |....||               .:
Mouse   967 CDIRKDNLQKKDESEEFLKRFQMVASLQENFEVFLPFED--YSNTALVAGLREQYIKAQEAAQAE 1029

  Fly   932 HRFR-----LRKFGILLSCSSELIPLHRRHCLLDEAIERIIERAQATLN-------VSAFIASEI 984
            |:.|     ....|..||..|:   |||:...| :..|:.:| |:.||.       |:|.  |:.
Mouse  1030 HKHRGPPGPTPARGTHLSIKSK---LHRQALAL-QVSEQELE-AELTLRALKDGKVVAAL--SKC 1087

  Fly   985 SEL----CTA-LGLPKVFGLHRICQRI---------GCLPLSCA---LAYHVVSFVDCVP----- 1027
            .:|    |.| .|........::||.:         |.|.|...   ||.|.|:.  |.|
Mouse  1088 RDLLKHYCNADTGRLLFVVCQKLCQMLADDVPMVAPGGLSLPSEIHDLACHAVTI--CSPDYLLD 1150

  Fly  1028 -ANAGEFVNLALELLVQ--------QIESAKGKNQ---ETASSLQLINEN-----DPLSFYLAYE 1075
             ....::...|:||..|        .:::|.|.::   |..|.....:|:     ..:...:.||
Mouse  1151 VLELSKYTLTAVELCRQCQMDDCGMLMKAALGTHKDPYEEWSFSDFFSEDGIVLESQVVLPVIYE 1215

  Fly  1076 LLTSALLHESSRRHDLVELIKYIRVAVIHYPLDAIKSHYDGKEQAVNEHICRALDGISVAL---- 1136
            |::|.:....|:||                |||:|...|....:..| .|...:..||..|
Mouse  1216 LISSVMPPAESKRH----------------PLDSISLPYCSTSEGEN-RILPLVSSISALLRSLQ 1263

  Fly  1137 ----GETTINFSCALNGSFDVKTLTVPTTTKKRYSVSMFDEVEVQPIQQQPQKKSVGGRMAIVKF 1197
                .|..:.|   :.|||.         |..::|:|                    ..|:|
Mouse  1264 ECSQWELALRF---VVGSFG---------TCLQHSMS--------------------NVMSI--- 1293

  Fly  1198 LARTLLLMVIETEPNNSLLMQVRNELPENTKADVESACADFFLSLEHLTKVKEHDAWYVMSQYLL 1262
                            ||..|:   |.:||.|:          |...:.::||..         :
Mouse  1294 ----------------SLSKQL---LGKNTLAN----------SRHIIMELKEKS---------I 1320

  Fly  1263 DFQKQNCRT--KRIINEGFITLQLRRIFRNAMGSKDV-------------NFIELFTMLVVDSEA 1312
            .|.::|..|  .::.|...:.|.|...:...:..|||             |:.::..:.:|.|:
Mouse  1321 TFIRENATTLLHKVFNCRVVDLDLALAYCTLLPQKDVFDNLWKFIDKAWQNYDKILALSLVGSQ- 1384

  Fly  1313 LALLEKLSVEVKTDLQKINFLTLSAMYHEHIEDLDSVHMIRTKRLKLFYYLEFCQQDHRIKGKFN 1377
               |..|..:::|.|          .:||  ..:|:...||..:|.:.:...| :|:...|
Mouse  1385 ---LANLYQDIETGL----------WFHE--LSIDAKWGIRLGKLGISFQPAF-RQNFLTK---- 1429

  Fly  1378 ADMDNIEDLLKEF-HNKQLDVQLLERMSKDFGFDYQ---KILITQILSILSAQELRFEVKRDTFG 1438
                  :||:|.. :|..:|..|:......|..|..   ::.|..:|...|:|. :.:...::..
Mouse  1430 ------KDLIKALVNNIDMDTSLILEYCSTFQLDSDAALRLFIETLLRNTSSQS-QGDAAPESTK 1487

  Fly  1439 DEELVMLSSAQEMRDMCQPYINEINNVELFTSKLKHFIEDINIYFYELYMCVINILMYFDSAPKE 1503
            .:...:|:.|.|:       :..:.|.:.....|...:..::.|.||:...|:.:|    ....|
Mouse  1488 HQHSKLLAKATEL-------VPLLKNTKDLVISLSEILYKLDPYDYEMIDVVLKVL----EQANE 1541

  Fly  1504 MEIWMNI---LHFLRHKMITRRRNRPGQVETDTWLKSQRENGVMPKISRYRLPFKPIV---EQPL 1562
            ....:||   |:.|||....||.:.|...|....|:...   .:|..:..||||..|:   .|..
Mouse  1542 KITSVNINQALNLLRHLKSYRRISPPVDHEYQYALEHMI---TLPPAAHTRLPFHLILFGTAQNF 1603

  Fly  1563 KDILDSELNVDNCQSWFPLIQMYTALKGSKDSSQNCDYFCMSAVKNSISE------YKSKNDSES 1621
            ..||.|||:.::..:   |:.:...:|.|.|:      ..:|..|:...:      .||.....|
Mouse  1604 WKILSSELSEESLPT---LLLIAKLMKFSLDT------LYVSTAKHLFEKNLKPKLLKSAQARSS 1659

  Fly  1622 WSLHPTNNAFLQSILRLVEKVNNPNKAFLILYFVSNYARDGADQVEASYECWKFVKEKGHLITDP 1686
            ..:....:..:|::...:..:.||..|..|...::....:|..::.:...| .::.|: .|...|
Mouse  1660 TLMSKEVDKLMQTLESYLLSIVNPEWAVAIAISLTQEVPEGPFKMSSLKFC-LYLAER-WLQNIP 1722

  Fly  1687 KSREQVAKVKRRYPIQK----------TQHLLYVYGLTDEKLLRQVENPTELIQALYHH-----E 1736
            ...|...|.|   .:||          |:.:|..:.|.|::.||.:..|..||.:||.|     .
Mouse  1723 PQDETCEKAK---ALQKKLCLQVRLSGTEAVLIAHKLNDQEYLRVIGKPAHLIVSLYEHPSISER 1784

  Fly  1737 LILKSSK--VDINALVAEIAKLHDLCLATIQYRLLQKWL---ALTMESAGDGTILEETFMEEQNW 1796
            |...|.|  .||:....|||:::::.|..|...||:|||   .:..|.|.:...|||
Mouse  1785 LCTTSGKDYPDIHTAAKEIAEVNEVNLEKIWDMLLEKWLCPSTVPSEKASEFFELEE-------- 1841

  Fly  1797 PEQANGAESSNSQDASENVNRAFYILSSWPKAEAVKFLVGLIFKGGSVNTST----------QLQ 1851
                           .|.::|..|:|.:.|    |.:...::|...:..|||          :.:
Mouse  1842 ---------------DEVLHRVVYLLQARP----VDYCSRMLFVFATSATSTLGMRQLTFAHKAR 1887

  Fly  1852 MYECYSKLNDG---SNSFTNTISQRQFISIKCVHEL---KALGYKSNLEKFSDDHCN--KIDILK 1908
            ..:|...|.|.   .:.|...|.:.:.. :||:..|   :.|......|.|    ||  |..::|
Mouse  1888 ALQCLLYLADKETIESLFKKPIKEMKSY-LKCITFLASFETLNIPITYELF----CNSPKEGMIK 1947

  Fly  1909 MIWQRNAQNPLSLEVMANICLGFDIHLPQIWNGILKRMVMFHMVRELNALLDVLSCRPHLLHLDG 1973
            .:|:.::..|:::.::|.:||.:.|:..|:|||:|::::.|:|:..|..:|..:|....|..:..
Mouse  1948 GLWKNHSHEPMAVRLVAELCLEYKIYDLQLWNGLLQKLLGFNMIPYLRKVLSCISSIHSLWQVPY 2012

  Fly  1974 LAQAWDYVLCHPLQNA-VELRSFKQEEVLHKTLLRLQGCPVVHALNLLQFAQLCIVVHRPHMAAS 2037
            .::||..|:..||.:| ..||..:..:.. .:|:.:..|||...|:::..|:..:.:..|..|.:
Mouse  2013 FSKAWQRVIQIPLLSASCPLRPSQLADCC-DSLVAILECPVSDDLDMMGVAKQYVQLDLPAFALT 2076

  Fly  2038 LLSFCQSSEQR-QKIKKMIHSHPVENLRQQILDLEDAGIL--------PVVLNFAL--KELNL 2089
            .|:....||:| |:||..::|.....:.|||.:..:.|.|        .:|||..:  ||..:
Mouse  2077 CLTLMPHSEKRHQQIKNFLNSCDARIILQQIEEHMNTGQLAGFSHQIGSLVLNHVVNKKEFGI 2139

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rod	NP_476705.1	Rod_C	1544..2082	CDD:287465	141/594 (24%)
Kntc1	NP_001035886.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1024..1045		3/20 (15%)
Kntc1	NP_001035886.1	Rod_C	1582..2126	CDD:287465	139/590 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850436
Domainoid	1	1.000	126	1.000	Domainoid score	I5416
eggNOG	1	0.900	-	-		E1_KOG4256
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	238	1.000	Inparanoid score	I3368
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52014
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007375
OrthoInspector	1	1.000	-	-		oto94777
orthoMCL	1	0.900	-	-		OOG6_106565
Panther	1	1.100	-	-	LDO	PTHR15688
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3830
SonicParanoid	1	1.000	-	-		X6266
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.790