Protein Alignment pygo and Pygo1

DIOPT Version :9

• Sequence 1: NP_651872.1
• Gene: pygo / 43718
• FlyBaseID: FBgn0043900
• Length: 815
• Species: Drosophila melanogaster
• Sequence 2: NP_082392.1
• Gene: Pygo1 / 72135
• MGIID: 1919385
• Length: 417
• Species: Mus musculus
• Alignment Length: 602
• Identity: 122/602 - (20%)
• Similarity: 182/602 - (30%)
• Gaps: 242/602 - (40%)

  Fly   238 GGMSPMGGMGGPSISPHHMGMGGLSPMGGGPNGPNPRA-MQGS---PMG--GPGQNSPMNSLPMG 296
            ||.|.:.|:|||:|..            |.|:....:| .|||   |:.  .|..|...:.|...
Mouse    17 GGDSGLDGLGGPNIQL------------GSPDKKKRKANTQGSSFPPLSEYAPPPNPNSDHLVAA 69

  Fly   297 SPMGNPIGS----PLGPPSGP--GPGNPGNTGGPQQQQQQPPQPP-MNNGQMGPPPLHS---PLG 351
            :|..:...:    || |.|.|  |||.|| .||....:..|..|| |::...||..|.:   |..
Mouse    70 NPFDDSYNTISYKPL-PSSNPYLGPGYPG-FGGYSTFRMPPHVPPRMSSPYCGPYSLRNQPHPFP 132

  Fly   352 NGPTGHGSHMPGGPIPGPGPGPGGLVGPGGISPAHGNNPGGSGNNMLGGNPGGGNSNNNGSNTSN 416
            ..|.|.|.:.|                       |..|.|...|:..|..|        .:|...
Mouse   133 QNPLGMGFNRP-----------------------HAFNFGPHDNSNFGNPP--------YNNVLT 166

  Fly   417 ASNNNQNPHLSPAAGRLGVPTSMQSNGPSVSSVASSSVPSPATPTLTPTSTATSMSTSVPTSSPA 481
            ...|....|.            .|.:..:.|.:...:|...:.|.|
Mouse   167 QDINMPGQHF------------RQGSAENFSQIPPQNVGQVSNPDL------------------- 200

  Fly   482 PPAMSPHHSLNSAGPSPGMPNSGPSPLQSPAGPNGPNNNNSNNNNGPMMGQMIPNAVPMQHQQHM 546
                       ::..:||..::..|||::         |:|          .||
Mouse   201 -----------ASNFAPGNNSNFTSPLET---------NHS----------FIP----------- 224

  Fly   547 GGGPP---GHGPGPMPGMGMNQ--MLPPQQPSHLGPPHPNMMNHPHHPHHHPGGPPPHMMGGPGM 606
               ||   |....|:|.....|  ...|.|.|...|||.||.:
Mouse   225 ---PPNAFGQAKAPLPKQDFTQGATKTPNQNSSTHPPHLNMED---------------------- 264

  Fly   607 HGGPAGMPPHMGGGPNPHMMGGPHGNAGPHMGHGHMGGVPGPGPGPGGMNGPPHPHMSPHHGHPH 671
                                  |...:...:.:.:...|.......|....            .:
Mouse   265 ----------------------PVNQSNVELKNVNRNNVVQENSRSGSAEA------------TN 295

  Fly   672 HHHNPMGGPGPNMFGGGGGGPMGPGGPMGNMGPMGGGPMGGPMGVGPKP-MTMGGGKMYPPGQPM 735
            :|.|                                       |...|| ...|...:..|.:..
Mouse   296 NHAN---------------------------------------GTQNKPRQPRGAADLCTPDKSR 321

  Fly   736 VFN--PQ---NPNAPPIYPCGMCHKEVNDNDEAVFCESGCNFFFHRTCVGLTEAAFQMLNKEVFA 795
            .|:  |.   :.::.|:||||:|..||||:.:|:.||:.|..:|||.|.|:||.|:.:|..|..|
Mouse   322 KFSLLPSRHGHSSSDPVYPCGICTNEVNDDQDAILCEASCQKWFHRICTGMTETAYGLLTAEASA 386

  Fly   796 EWCCDKCVSSKHIPMVK 812
            .|.||.|::.|.:.:::
Mouse   387 VWGCDTCMADKDVQLMR 403

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pygo	NP_651872.1	PHD_dPYGO	749..802	CDD:277107	26/52 (50%)
Pygo1	NP_082392.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..71		18/65 (28%)
		Nuclear localization signal. /evidence=ECO:0000255	35..41		1/5 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	175..265		29/208 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	284..318		7/84 (8%)
		PHD_PYGO1	339..395	CDD:277105	28/55 (51%)
		Interaction with H3K4me2. /evidence=ECO:0000250	339..386		23/46 (50%)
		Interaction with BCL9. /evidence=ECO:0000250	371..389		7/17 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837987
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004253
OrthoInspector	1	1.000	-	-		otm43414
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23194
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4735
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.060