Protein Alignment pygo and PYGO1

DIOPT Version :9

• Sequence 1: NP_651872.1
• Gene: pygo / 43718
• FlyBaseID: FBgn0043900
• Length: 815
• Species: Drosophila melanogaster
• Sequence 2: NP_001317255.1
• Gene: PYGO1 / 26108
• HGNCID: 30256
• Length: 419
• Species: Homo sapiens
• Alignment Length: 605
• Identity: 122/605 - (20%)
• Similarity: 175/605 - (28%)
• Gaps: 246/605 - (40%)

  Fly   238 GGMSPMGGMGGPSISPHHMGMGGLSPMGGGPNGPN-PRAMQGSPMGGPGQNSPMNSLPMGSPMGN 301
            ||.|.:.|:|||.:   .:|............||: |...:.:|...|..:..:.:.|.......
Human    17 GGDSGLDGLGGPGV---QLGSPDKKKRKANTQGPSFPPLSEYAPPPNPNSDHLVAANPFDDNYNT 78

  Fly   302 PIGSPLGPPSGP--GPGNPGNTGGPQQQQQQPPQPP-MNNGQMGPPPLHS---PLGNGPTGHGSH 360
            ....|| |.|.|  |||.|| .||....:..|..|| |::...||..|.:   |....|.|.|.:
Human    79 ISYKPL-PSSNPYLGPGYPG-FGGYSTFRMPPHVPPRMSSPYCGPYSLRNQPHPFPQNPLGMGFN 141

  Fly   361 MPGGPIPGPGPGPGGLVGPGGISPAHGNNPGGSGNNMLGGNPGGGNSNNNGSNTSNASNNNQNPH 425
            .|                       |..|.|...|:..      ||.:.|.:.:.|.:..||:..
Human   142 RP-----------------------HAFNFGPHDNSSF------GNPSYNNALSQNVNMPNQHFR 177

  Fly   426 LSPAAGRLGVPTSMQSNGPSVSS--VASSSVPSPATPTLTPTSTATSMSTSVPTSSPAPPAMSPH 488
            .:||.....:|   ..|...||:  :||:.|
Human   178 QNPAENFSQIP---PQNASQVSNPDLASNFV---------------------------------- 205

  Fly   489 HSLNSAGPSPGMPNSGPSPLQSPAGPNGPNNNNSNNNNGPMMGQMIPNAVPMQHQQHMGGGPP-- 551
                     ||..::..|||:|         |:|          .||              ||
Human   206 ---------PGNNSNFTSPLES---------NHS----------FIP--------------PPNT 228

  Fly   552 -GHGPGPMPGMGMNQMLPPQQPSHLGPPHPNMMNHPHHPHHHPGGPPPHMMGGPGMHGGPAGMPP 615
             |....|          ||:|....|.......|...|                         ||
Human   229 FGQAKAP----------PPKQDFTQGATKNTNQNSSAH-------------------------PP 258

  Fly   616 HMG-----GGPNPHMMGGPHGNA-GPHMGHGHMGGVPGPGPGPGGMNGPPHP------------H 662
            |:.     ...|..:......|| ................|..|..|.|..|            :
Human   259 HLNMDDTVNQSNIELKNVNRNNAVNQENSRSSSTEATNNNPANGTQNKPRQPRGAADACTTEKSN 323

  Fly   663 MSPHHGHPHHHHNPMGGPGPNMFGGGGGGPMGPGGPMGNMGPMGGGPMGGPMGVGPKPMTMGGGK 727
            .|..|.:.|.|
Human   324 KSSLHPNRHGH------------------------------------------------------ 334

  Fly   728 MYPPGQPMVFNPQNPNAPPIYPCGMCHKEVNDNDEAVFCESGCNFFFHRTCVGLTEAAFQMLNKE 792
                          .::.|:||||:|..||||:.:|:.||:.|..:|||.|.|:||.|:.:|..|
Human   335 --------------SSSDPVYPCGICTNEVNDDQDAILCEASCQKWFHRICTGMTETAYGLLTAE 385

  Fly   793 VFAEWCCDKCVSSKHIPMVK 812
            ..|.|.||.|::.|.:.:::
Human   386 ASAVWGCDTCMADKDVQLMR 405

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pygo	NP_651872.1	PHD_dPYGO	749..802	CDD:277107	26/52 (50%)
PYGO1	NP_001317255.1	PHD_PYGO1	341..397	CDD:277105	28/55 (51%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147903
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	131	1.000	Inparanoid score	I4635
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004253
OrthoInspector	1	1.000	-	-		otm41357
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23194
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	5.080