DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pygo and Col8a1

DIOPT Version :9

Sequence 1:	NP_651872.1	Gene:	pygo / 43718	FlyBaseID:	FBgn0043900	Length:	815	Species:	Drosophila melanogaster
Sequence 2:	NP_031765.2	Gene:	Col8a1 / 12837	MGIID:	88463	Length:	744	Species:	Mus musculus

Alignment Length:	708	Identity:	206/708 - (29%)
Similarity:	239/708 - (33%)	Gaps:	269/708 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   150 GGPPPPPHMHPHMHPHHPG-GPMGH--PHGP--------------------HPHMGGPPPMRGMS 191
            |..|.||.:.|.:.|..|. .|:|.  ||.|                    :||:  |..|:.:.
Mouse    32 GIKPLPPQIPPQIPPQIPQYQPLGQQVPHMPLGKDGLSMGKEMPHMQYGKEYPHL--PQYMKEIP 94

  Fly   192 PMHPHQMG----PGPGVGLPPHMN-------HGRPGGPGGPGGPVPMGSPMGGIAGMGGMSPMGG 245
            |:  .:||    |..|.|..|..:       .|.||..|.||.|...|..|.||.|..|.....|
Mouse    95 PV--PRMGKEVVPKKGKGEVPLASLRGEQGPRGEPGPRGPPGPPGLPGHGMPGIKGKPGPQGYPG 157

  Fly   246 MGGPSI-----SPHHMGMGGLSPMGGGPNGPNPRAMQGSPMGGPGQNSPMNSLPMGSPMGNPIGS 305
            :|.|.:     .|..|||.|..    |..||....   .|||.||        |.|.|  .|.|.
Mouse   158 IGKPGMPGMPGKPGAMGMPGAK----GEIGPKGEI---GPMGIPG--------PQGPP--GPHGL 205

  Fly   306 P-LGPPSGPG-PGNPGNTG--GPQQQQQQPPQPPMNNGQ--------------MGPPPLHSPLGN 352
            | :|.|.||| ||.||..|  ||    :.||.||...|.              .|||.:|.|  .
Mouse   206 PGIGKPGGPGLPGQPGAKGERGP----KGPPGPPGLQGPKGEKGFGMPGLPGLKGPPGMHGP--P 264

  Fly   353 GPTG-HGSHMPG--------GPIPGPG----PGPGGLVG-PGGISPAHGNNPGGSGNNMLGGNPG 403
            ||.| .|...||        ||:..||    |||.||:| ||...|......|..|.:.:.|.||
Mouse   265 GPVGLPGVGKPGVTGFPGPQGPLGKPGPPGEPGPQGLIGVPGVQGPPGMPGVGKPGQDGIPGQPG 329

  Fly   404 --GGNSNNNGSNTSNASNNNQNPHLSPAAGRLGVPTSMQSNGPSVSSVASSSVPSPATPTLTPTS 466
              ||.                        |..|:|                .:|.|
Mouse   330 FPGGK------------------------GEQGLP----------------GLPGP--------- 345

  Fly   467 TATSMSTSVPTSSPAPPAMSPHHSLNSAGPSPGMPNSGPSPLQSPAGPNG----PNNNNSNNNNG 527
                                           ||:|..|......|.|..|    |.........|
Mouse   346 -------------------------------PGLPGVGKPGFPGPKGDRGIGGVPGVLGPRGEKG 379

  Fly   528 PMMGQMIPNAVPMQHQQHMGGGPPGHGPGPMPGMGMNQMLPPQQPSHLGPPHPNMMNHPHHPHHH 592
            |:      .|..|       |||||. || :||:          |..:||  |..:..| .|...
Mouse   380 PI------GAPGM-------GGPPGE-PG-LPGI----------PGPMGP--PGAIGFP-GPKGE 416

  Fly   593 PG--GP--PPHMMGGPGMHGGPAGMPPHMGGGPNPHMMG-----GPHGNAGPHMGHGHMGGVPG- 647
            .|  ||  ||...|.||:.|.| |.|..:|....|.|.|     ||.|..| |.|...:.||||
Mouse   417 GGVVGPQGPPGPKGEPGLQGFP-GKPGFLGEVGPPGMRGLPGPIGPKGEGG-HKGLPGLPGVPGL 479

  Fly   648 ------PG-PGPGGMNGPPHPHMSPHHGHPHHHHNPMGGPGPNMFGGGGGGPMGPGGPMGNMGPM 705
                  || ||..|:.|||        |.|                 |..||.||.||.|..||.
Mouse   480 LGPKGEPGIPGDQGLQGPP--------GIP-----------------GIVGPSGPIGPPGIPGPK 519

  Fly   706 G----GGPMGGPMGVGPKPMTMG-------GGKMYPPGQPMVFNPQNPNAPPIYPCGM 752
            |    .||.|.| ||| ||...|       .|.:.|.|||.:..|..|..||..|..|
Mouse   520 GEPGLPGPPGFP-GVG-KPGVAGLHGPPGKPGALGPQGQPGLPGPPGPPGPPGPPAVM 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pygo	NP_651872.1	PHD_dPYGO	749..802	CDD:277107	2/4 (50%)
Col8a1	NP_031765.2	Nonhelical region (NC2)	29..118		23/89 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	101..395		111/411 (27%)
		Triple-helical region (COL1)	119..572		181/612 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	412..439		11/27 (41%)
		Collagen	445..502	CDD:189968	24/82 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	457..590		52/147 (35%)
		Nonhelical region (NC1)	573..744		1/3 (33%)
		C1Q	609..744	CDD:128420
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000