Protein Alignment gammaCOP and APL1

DIOPT Version :9

• Sequence 1: NP_001263145.1
• Gene: gammaCOP / 43717
• FlyBaseID: FBgn0028968
• Length: 897
• Species: Drosophila melanogaster
• Sequence 2: NP_012538.3
• Gene: APL1 / 853461
• SGDID: S000003765
• Length: 700
• Species: Saccharomyces cerevisiae
• Alignment Length: 640
• Identity: 118/640 - (18%)
• Similarity: 239/640 - (37%)
• Gaps: 174/640 - (27%)

  Fly    63 AREATDCFFAMTKLFQSKD-----VVLRRMVYLGIKELSSIAEDVIIVTSSLTKDMTGKEDLYRA 122
            ||||..  |.|.. |:|:|     :.||.:|.:.:||||..|.|.||   ||....:..|.:.|
Yeast    91 AREALP--FIMDD-FKSRDEKLQIMALRTLVLVPVKELSDQAFDCII---SLVNHKSPPEQVTR- 148

  Fly   123 AAIRALCSITDNTMLQAVERYMKQCIVDKNAAVSCAALVSSLRLANTAGDVVKRWANEAQEALNS 187
            .||.||..:.:               :|....         |.|::...|:||     ||.  :|
Yeast   149 TAIYALLDLDE---------------IDHERV---------LGLSSILHDIVK-----AQS--SS 182

  Fly   188 DNIMVQYHALGLLYHIRKS---------------DRLAVSKLVNKLTRGSLKSPYAVCMLIRIAC 237
            ..::|.  ||..||.|.:.               |.|.:...:|:..:.:        :|..:..
Yeast   183 PEVIVA--ALHTLYSIHEKNANMEPFRIPLELAFDMLELLPELNEWNKAT--------VLEVLTT 237

  Fly   238 KLIEEEDIPSEELSDSPLFTFIESCLRHKSEMVIYEAAHA------IVN----LKNTNPRMLSPA 292
            .::.:..:.:.|:        ||..|.:..::..|...::      ::|    :|.|....||.
Yeast   238 SVVPQHYLDTHEM--------IELALPYLQQVNTYVVLNSLKFIMYLLNYVDVIKETLAEKLSN- 293

  Fly   293 FSILQLFCSSPKATLRFAAVRTLNKVAMTHPAAVTTCNLDLEGLITDSNRS--VATLAITTLLKT 355
             |::.|....|:  |:|..:|.:..:.::..:::  ..||:.....:.|..  :....:..|...
Yeast   294 -SVIALLDKPPE--LQFLVLRNVILLLLSRESSL--LRLDISYFFIEYNDPIYIKDTKLECLYLL 353

  Fly   356 GAESSVERLMKQISTFVAEISDEFKVVVVQAICALCTKYPRKH-----TVLMNFLSGMLREEGGL 415
            ..:.::.|:::::..:..:|..:.....|:||..|..|.....     .||::.|      |.|:
Yeast   354 ANKETLPRILEELEQYATDIDIQMSRKSVRAIGNLAVKLDEDSVHDCVAVLLDLL------EFGV 412

  Fly   416 EYKTSIVDTIITIIE-------ENADAKESGLSHLCEFIEDCEHVSLAVRILHLLGKEGPFAATP 473
            :|   :|..||::..       .|..|..:.|....|.:::.|..:..:.|:      ..::...
Yeast   413 DY---VVQEIISVFRNILRKYPNNFKANVTELVKHTEVVQEPESKNAMIWII------TQYSDVI 468

  Fly   474 SKYI---RFIYNRVILESPIVRAAAVTAMAQFGASCPALLSNIL---VLLGRCQMDPDDEVRDRA 532
            ..|:   |...:.:..|:..|:.:.:.:..:|....|...:..|   :|.|....:.:.::||:.
Yeast   469 PNYLELFRVFSSNMFSETLEVQFSILNSAIKFFIRSPTKETEELCMDLLKGCIDHENNPDLRDKT 533

  Fly   533 TYY---------------------LSILNSERPELYKNYIIERENCSLALLEKSLVEHLNGDVDT 576
            ..|                     .|:|:.|.|.:..|          ..|:.:::|.|..::.|
Yeast   534 LMYWRLLSLTKTSRISNAITFESLKSVLDGELPLIEMN----------TKLDPTVLEELELNIGT 588

  Fly   577 RFDI--------------SIVPKAAIVKPVIANDVMLVTSSAPRPPKITREEESA 617
            ...|              .::|::.|:.|  ..|::.|..::..|....|:.:::
Yeast   589 IVSIYLKPVSHIFRLNKTKLLPQSPILNP--NKDLLPVVGNSFPPTGANRDRQNS 641

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gammaCOP	NP_001263145.1	SEC21	11..877	CDD:227565	118/640 (18%)
		HEAT repeat	402..427	CDD:293787	6/24 (25%)
		HEAT repeat	439..465	CDD:293787	4/25 (16%)
		HEAT repeat	475..505	CDD:293787	5/32 (16%)
		HEAT repeat	512..538	CDD:293787	6/49 (12%)
		COP-gamma_platf	620..761	CDD:285908
		Coatomer_g_Cpla	763..877	CDD:292991
APL1	NP_012538.3	COG5096	1..700	CDD:227427	118/640 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910