DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gammaCOP and AT1G31730

DIOPT Version :9

Sequence 1:	NP_001263145.1	Gene:	gammaCOP / 43717	FlyBaseID:	FBgn0028968	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	NP_174454.2	Gene:	AT1G31730 / 840060	AraportID:	AT1G31730	Length:	938	Species:	Arabidopsis thaliana

Alignment Length:	727	Identity:	140/727 - (19%)
Similarity:	280/727 - (38%)	Gaps:	139/727 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 LEKTSVLQETRTFNETPVNPRKCIHILTKILYLINQGEQLVAREATDCFFAMTKLFQSKDVVLRR 86
            |.:..:|:  |...|..:..||....:.:::|:     :::..:|:..:....|:....:::|:|
plant    46 LSEVDILK--RRLLEPDIPKRKMKEYIIRLVYI-----EMLGHDASFGYIYAVKMTHDDNLLLKR 103

  Fly    87 MVYLGIKELSSIAED-VIIVTSSLTKDMTGKEDLYRAAAIRALCSITDNTMLQAVERYMKQCIVD 150
            ..||.:....:...| :|::.:::.||:.....|...||:.|:|.:.:...:.||...:.:.:..
plant   104 TGYLAVTLFLNEDHDLIILIVNTIQKDLRSDNYLVVCAALNAICRLINEETIPAVLPQVVELLNH 168

  Fly   151 KNAAVSCAALVSSLRLANTAGDVVKRWANEAQEALNSDNIMVQYHALGLLYHIRKSD----RLAV 211
            :..||...|:::..|....:...|....:..::.|..::..|....|..|:.:...|    :..|
plant   169 QKEAVRKKAIMALHRFHRKSPSSVSHLVSNFRKRLCDNDPGVMGATLCPLFDLISEDVNSYKDLV 233

  Fly   212 SKLVNKLTR------------GSLKSPYAVCMLIRIACKL----IEEEDIPSEELSDSPLFTFIE 260
            |..|:.|.:            ..:.:|:....|::|...|    ....||.|..|.|  ||...:
plant   234 SSFVSILKQVTERRLPKSYDYHQMPAPFIQIKLLKIMALLGSGDKNASDIMSMVLGD--LFRKCD 296

  Fly   261 SCLRHKSEMVIYEAAHAIVNLKNTNPRMLSPAFSILQLFCSSPKATLRFAAVRTLNK-------V 318
            |. .:....::||....|..:. .||::|..|...:..|..|....|::..:..|.:       :
plant   297 SS-TNIGNAILYECIRCISCIL-PNPKLLEAAADAISKFLKSDSHNLKYMGIDGLGRLIKISPDI 359

  Fly   319 AMTHPAAVTTCNLDLEGLITDSNRSVATLAITTLLKTGAESSVERLMKQISTFVAEISD-EFKVV 382
            |..|..||..|       :.|.:.::.......|.|....|:||.::.::..::..|:| .:|..
plant   360 AEQHQLAVIDC-------LEDPDDTLKRKTFELLYKMTKSSNVEVIVDRMIDYMISINDNHYKTE 417

  Fly   383 VVQAICALCTKYPRKHTVLMNFLSGMLREEGGLEYKTSIVDTIITII-------EENADAK--ES 438
            :......|..::...:...:..::.:....|.| ....:...::.:|       :::||:|  .|
plant   418 IASRCVELAEQFAPSNQWFIQIMNKVFEHAGDL-VNIKVAHNLMRLIAEGFGEDDDDADSKLRLS 481

  Fly   439 GLSHLCEFIEDCEHVSLAVRILH-LLGKEGPFAATPSKY-IRFIYNRV------ILESPIVRAAA 495
            .:....:.|.:.:..||.::::. :||:.|   ....|| ..:|..::      ......|:..|
plant   482 AVESYLQLISEPKLPSLFLQVISWVLGEYG---TADGKYSASYISGKLCDVADAYSSDETVKGYA 543

  Fly   496 VTAMAQFGA-------------SCPALL-----------------------------SNILVLLG 518
            |:|:.:..|             .|.:|:                             ..||.|..
plant   544 VSALMKIYAFEIASGRKVDVLPECQSLIEELLASHSTDLQQRAYELQALLALDARAVETILPLDA 608

  Fly   519 RCQMDPDDEV-RDRATYYLSILNSERPELYKN----YIIERENCSL-ALLEKSLVEHLNGDVDT- 576
            .|:   |.|| :|     ||.||....:..::    ||.|||...: ...:....:|  .:|.|
plant   609 SCE---DIEVDKD-----LSFLNGYIQQAIESGAQPYISERERSGMFETTDYHPQDH--HEVPTH 663

  Fly   577 --RFDISIVPKAAIVKPVIANDVMLV-------TSSAPRPPKITREEESAARLAQLPGI-QVLG- 630
              ||:...:||.: |.|..:|:::.|       .|..|....:..|.||:....:|.|: |..|
plant   664 ALRFEAYELPKPS-VPPQASNELVPVPEPSYYSESHQPISTSLVSERESSEIKLRLDGVKQKWGR 727

  Fly   631 PIHRSTAPIQLT 642
            |.::||.....|
plant   728 PSYQSTTAASST 739

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gammaCOP	NP_001263145.1	SEC21	11..877	CDD:227565	140/727 (19%)
		HEAT repeat	402..427	CDD:293787	2/24 (8%)
		HEAT repeat	439..465	CDD:293787	4/26 (15%)
		HEAT repeat	475..505	CDD:293787	8/49 (16%)
		HEAT repeat	512..538	CDD:293787	9/26 (35%)
		COP-gamma_platf	620..761	CDD:285908	8/25 (32%)
		Coatomer_g_Cpla	763..877	CDD:292991
AT1G31730	NP_174454.2	Adaptin_N	41..593	CDD:279882	99/568 (17%)
		HEAT repeat	123..148	CDD:293787	6/24 (25%)
		HEAT repeat	157..185	CDD:293787	6/27 (22%)
		HEAT repeat	194..221	CDD:293787	4/26 (15%)
		HEAT repeat	320..351	CDD:293787	7/30 (23%)
		HEAT repeat	363..391	CDD:293787	7/34 (21%)
		HEAT repeat	401..428	CDD:293787	4/26 (15%)
		HEAT repeat	439..461	CDD:293787	2/22 (9%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910