DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gammaCOP and AT5G22780

DIOPT Version :9

Sequence 1:	NP_001263145.1	Gene:	gammaCOP / 43717	FlyBaseID:	FBgn0028968	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	NP_001330127.1	Gene:	AT5G22780 / 832341	AraportID:	AT5G22780	Length:	1013	Species:	Arabidopsis thaliana

Alignment Length:	1037	Identity:	185/1037 - (17%)
Similarity:	351/1037 - (33%)	Gaps:	292/1037 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 NETPVNPRKCIHILTKILYLINQGEQLVAREATDCFFAMTKLFQSKDVVLRRMVYLGIKELSSIA 99
            ||..:.|.|....:.|:||:     .::..:..........|..:.....:::.|:....|.:..
plant    40 NEKVLTPYKKKKYVWKMLYI-----HMLGYDVDFGHMEAVSLISAPKYPEKQVGYIVTSCLLNEN 99

  Fly   100 EDVI-IVTSSLTKDMTGKEDLYRAAAIRALCSITDNTMLQAVERYMKQCIVDKNAAVSCAALVSS 163
            .|.: :..:::..|:.|:.:.::..|:..:.:|......:::...:::.::..    ||..||..
plant   100 HDFLKLAINTVRNDIIGRNETFQCLALTLVGNIGGRDFAESLAPDVQKLLISS----SCRPLVRK 160

  Fly   164 ------LRLANTAGDVVK--RWANEAQEALNSDNIMVQYHALGLLYHIRKSDRLAVSKLVNKLTR 220
                  |||.....|.|.  .||:...:.|:..:       ||:|   ..|..|.|:.:.|.
plant   161 KAALCLLRLFRKNPDAVNVDGWADRMAQLLDERD-------LGVL---TSSTSLLVALVSNN--- 212

  Fly   221 GSLKSPYAVCM--LIRIACKLIEEEDIPSE-----------------------ELSD----SPLF 256
               ...|:.|:  .::|..:|...:|:|.|                       .:.|    ..||
plant   213 ---HEAYSSCLPKCVKILERLARNQDVPQEYTYYGIPSPWLQVKAMRALQYFPTIEDPSTRKALF 274

  Fly   257 TFIESCL-----------RHKSEMVIYEAAHAIVNLKNTNPRMLSPAFSILQLFCSSPKATLRFA 310
            ..::..|           .:.|..|::||...:::| :....|:|...::|..|.|..:..:|:.
plant   275 EVLQRILMGTDVVKNVNKNNASHAVLFEALSLVMHL-DAEKEMMSQCVALLGKFISVREPNIRYL 338

  Fly   311 AVRTLNKVAMT---------HPAAVTTCNLDLEGLITDSNRSVATLAITTLL----KTGAESSVE 362
            .:..:.::.|.         |.:.:.|.       :.|.:.|:...|:..|.    .:.|:..||
plant   339 GLENMTRMLMVTDVQDIIKKHQSQIITS-------LKDPDISIRRRALDLLYGMCDVSNAKDIVE 396

  Fly   363 RLMKQISTFVAEISDEFKVVVVQAICALCTKYPRKHTVLMNFLSGMLREEGGLEYKTSIVDTIIT 427
            .|::.:||  ||.|...::.:..||  |..|:....:..::.:..::.:.|.. ....|...::.
plant   397 ELLQYLST--AEFSMREELSLKAAI--LAEKFAPDLSWYVDVILQLIDKAGDF-VSDDIWFRVVQ 456

  Fly   428 IIEENADAKESGLSHLCEFIEDCE-HVSLAVRILHLLGKEGPFAA-----TPSKYIRFIYNRVIL 486
            .:..|.|.:....|...|:::... |.::.....::||:.|...|     :.|:....::.::
plant   457 FVTNNEDLQPYAASKAREYMDKIAIHETMVKVSAYILGEYGHLLARQPGCSASELFSILHEKL-- 519

  Fly   487 ESPIVRAAAVTAMAQFGASCPALLSNILVLLGRCQ-MDP-----------------DDEVRDRAT 533
              |.|....:          |.|||....||...| .||                 |.|::.||.
plant   520 --PTVSTPTI----------PILLSTYAKLLMHAQPPDPELQKKVWAVFKKYESCIDVEIQQRAV 572

  Fly   534 YYLSILNSERPELYKNYIIERENCSLALLEKSLVEHLNGDVDTRFDISIVPKAAIVKPVIANDVM 598
            .|..:  |::...:.:.:.|..  .....:.||::......||. |.|.:...|..:|  :|.::
plant   573 EYFEL--SKKGPAFMDVLAEMP--KFPERQSSLIKKAENVEDTA-DQSAIKLRAQQQP--SNAIV 630

  Fly   599 LV----TSSAPRPPKI-----TREEESAARL------------AQLPGIQVL------------- 629
            |.    .:.||.|.|:     :.:.||.||.            .|.|...:|
plant   631 LADPQPVNGAPPPLKVPILSGSTDPESVARSLSHPNGTLSNIDPQTPSPDLLSDLLGPLAIEAPP 695

  Fly   630 --------GPIHRSTAPIQLTES------ETEYTVQ------------CIK---------HI--- 656
                    ||:.....|.::..|      |...||:            |:|         ||
plant   696 GAVSYEQHGPVGAEGVPDEIDGSAIVPVEEQTNTVELIGNIAERFHALCLKDSGVLYEDPHIQIG 760

  Fly   657 --------FGQHVVFQFDCLNTLSDQILENVRVELTLPEGFTTRAVIPCPKL--PYNDLQTTFVI 711
                    .|:.|:|    :...:...|.:|:. |.||.......:.|.|..  |...:|:...:
plant   761 IKAEWRGHHGRLVLF----MGNKNTSPLTSVQA-LILPPAHLRLDLSPVPDTIPPRAQVQSPLEV 820

  Fly   712 VEFPPDAANSIATFGATLRFVVKDCDPNTGEPESEEGYDDEYMLEDLELTVADQIQKTRKNNFQV 776
            :...|  :..:|....:.:|...........|.:...:     |:.|:||         ...|..
plant   821 MNIRP--SRDVAVLDFSYKFGTNVVSAKLRIPATLNKF-----LQPLQLT---------SEEFFP 869

  Fly   777 SWDAADSEEWLQAEDTFVLSAVTTLQDAVNTIVKILGLGAANLSENVPEGTHLHTLLCSG----- 836
            .|.|             :......||:.|..:..:.....|||..:      .|..:|.|
plant   870 QWRA-------------ISGPPLKLQEVVRGVRPLALPEMANLFNS------FHVTICPGLDPNP 915

  Fly   837 -------TF----RGGAEILVRAKLALSEGVTLNLTVRSTDQDVA---------ELITAAIG 878
                   ||    .|....|.|.:...::...|.|||.|.|..:.         :|||..:|
plant   916 NNLVASTTFYSETTGAMLCLARIETDPADRTQLRLTVGSGDPTLTFELKEFIKEQLITIPMG 977

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gammaCOP	NP_001263145.1	SEC21	11..877	CDD:227565	184/1034 (18%)
		HEAT repeat	402..427	CDD:293787	2/24 (8%)
		HEAT repeat	439..465	CDD:293787	4/26 (15%)
		HEAT repeat	475..505	CDD:293787	2/29 (7%)
		HEAT repeat	512..538	CDD:293787	10/43 (23%)
		COP-gamma_platf	620..761	CDD:285908	32/213 (15%)
		Coatomer_g_Cpla	763..877	CDD:292991	26/138 (19%)
AT5G22780	NP_001330127.1	Adaptin_N	23..582	CDD:279882	105/595 (18%)
		HEAT repeat	323..347	CDD:293787	4/23 (17%)
		HEAT repeat	359..387	CDD:293787	6/34 (18%)
		HEAT repeat	397..427	CDD:293787	10/33 (30%)
		Alpha_adaptinC2	751..844	CDD:197886	17/99 (17%)
		Alpha_adaptin_C	856..965	CDD:280460	27/141 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910