DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gammaCOP and ap2a1

DIOPT Version :9

Sequence 1:	NP_001263145.1	Gene:	gammaCOP / 43717	FlyBaseID:	FBgn0028968	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	XP_009297842.1	Gene:	ap2a1 / 558153	ZFINID:	ZDB-GENE-090302-2	Length:	984	Species:	Danio rerio

Alignment Length:	949	Identity:	197/949 - (20%)
Similarity:	359/949 - (37%)	Gaps:	209/949 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 LFQSKDVVLRRMVYLGIKEL-SSIAEDVIIVTSSLTKDMTGKEDLYRAAAIRALCSITDNTMLQA 139
            |..|.....:::.||.|..| :|.:|.:.::.:::..|::.:...:...|:..:.::....|.:|
Zfish    82 LLSSNKYTEKQIGYLFISVLVNSNSELIRLINNAIKNDLSSRNPTFMCLALHCIANVGSREMAEA 146

  Fly   140 VERYMKQCIV--DKNAAVSCAALVSSLRLANTAGDVV--KRWANEAQEALNSDNIMVQYHALGLL 200
            ....:.:.:|  |...:|..:|.:..|||..|:.|:|  ..|.:.....||..::.|...|:.|:
Zfish   147 FAGEIPRILVAGDTMDSVKQSAALCLLRLYKTSPDLVLMGEWTSRVVHLLNDQHMGVVTAAISLI 211

  Fly   201 YHIRKSD--------RLAVSKLVNKLTRGS----------LKSPYAVCMLIRIACKLIEEEDIPS 247
            ..:.:.:        .||||:|...::..|          :.:|:..|.|:|    |::....|.
Zfish   212 TCLSQKNPDEFKTCVSLAVSRLSRIVSSASTDLQDYTYYFVPAPWLSCKLLR----LLQCYPPPE 272

  Fly   248 EELSDSPLFTFIESCLRHKSE--------------MVIYEAAHAIVNLKNTNPRMLSPAFSILQL 298
            :......|...:|:.|....|              .:::||...|::. ::.|.:|..|.:.|..
Zfish   273 DGAVKGRLVECLETILNKAQEPPKSKKVQHSNAKNAILFEAISLIIHY-DSEPNLLVRACNQLGQ 336

  Fly   299 FCSSPKATLRFAAVR---TLNKVAMTHPAAVTTCNLDLEGLITDSNRSVATLAITTLLKTGAESS 360
            |....:..||:.|:.   ||.....:|.|..|.....:..|.|:.:.||...|...|......|:
Zfish   337 FLQHRETNLRYLALESMCTLASSEFSHEAVKTHIETVINALKTERDVSVRQRAADLLYAMCDRSN 401

  Fly   361 VERLMKQISTFVAEISDEFKVVVVQAICALCTKYPRKHTVLMNFLSGMLREEGGLEYKTSIV-DT 424
            .::::.::.:::.......:..:|..:..|..||...::..::.:..::|..|  :|.:..| ..
Zfish   402 AKQIVAEMLSYLETADYSIREEMVLKVAILAEKYAVDYSWYVDTILNLIRIAG--DYVSEEVWYR 464

  Fly   425 IITIIEENADAKESGLSHLCEFIE--DCEHVSLAVRILHLLGKEGPFAA-----TPSKYIRFIYN 482
            :|.|:....|.:......:.|.::  .| |.::.....::||:.|...|     :|......:::
Zfish   465 VIQIVINRDDVQGYAAKTVFEALQAPAC-HENMVKVGGYILGEFGNLIAGDPRSSPLVQFNLLHS 528

  Fly   483 RVILESPIVRAAAVTAMAQFGASCPALLSNIL-VLLGRCQM-DPDDEVRDRATYYLSILNSERPE 545
            :..|.|...||..::|..:|....|...|.|. ||....|: :.|.|::.||..||.:.:....:
Zfish   529 KFHLCSVPTRALLLSAYIKFINLFPETKSTIQEVLRSDSQIRNSDVELQQRAVEYLKLSSIASTD 593

  Fly   546 LYKNYI------IERENCSLALLEK----------SLVE------HLNGDVDTR-FDISIVPKAA 587
            :....:      .|||:..||.|:|          .|.|      .|||....| .|.|.:..:.
Zfish   594 VLATVLEEMPPFPERESSILAKLKKKKGPGAVSVNELEEGKREGGELNGGGGERGGDNSTIAASN 658

  Fly   588 IVKPVIANDVMLV-----TSSAP-------------------------RPPKITREEESAARLAQ 622
            ...|..:.|::.:     .|:||                         .||    .|.|.:.||:
Zfish   659 ASTPSPSADLLGLRTGPQVSAAPPSAGSLLVDVFSEAGVNDDGFLRDLEPP----TESSDSLLAE 719

  Fly   623 LPGIQVLGP---IHRSTAPIQLTESETEYTVQCIKHIFGQHVVFQFDCLNT---LSDQILE-NVR 680
            .||.....|   :....|| .|.||              ..::.:|.|.|.   ..:|:|: .::
Zfish   720 GPGDSDSAPPSAVSEDAAP-PLPES--------------NELLNKFVCKNNGVLFENQLLQIGIK 769

  Fly   681 VELTLPEG----------------FTTRAVIPCPKLPYNDLQTTFVIVEFPPDAANSIATFGATL 729
            .|.....|                |||  .:.||    .:||:...:...|   ...:...||.:
Zfish   770 SEYRQNLGRMYLFYGNKTSVQFVTFTT--TVSCP----GELQSQLNVQAKP---VEPLIEGGAQV 825

  Fly   730 RFVVK-DCDPNTGE-PESEEGYDDEYMLEDLELTVADQIQKTRKNNFQVSWDAADSEEWLQ---- 788
            :.|:. :|..:..| |.....:.....|::|.|.:...|.|..:.....|.|.  .:.|.|
Zfish   826 QQVINIECLGDFCEAPLLNIKFRYGGALQNLSLKLPVTINKFFQPTEMASHDF--FQRWKQLSQP 888

  Fly   789 ------------AEDTFVLSAVTTLQDAVNTIVKILGLGAANLSENV---PEGTHLHTLLCSGTF 838
                        |.||.|:.|            |:||||.| |.|||   ||     ..:|:|..
Zfish   889 QQEAQKIFKASHAMDTEVIKA------------KLLGLGMA-LLENVDPNPE-----NFVCAGVI 935

  Fly   839 RGGAE---ILVRAK---LALSEGVTLNLTVRSTDQDVAE 871
            :..|:   .|:|.:   .|.|......||:||:...|::
Zfish   936 QTKAQQVGSLLRLEPNAQAQSGEQMYRLTLRSSKDTVSK 974

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gammaCOP	NP_001263145.1	SEC21	11..877	CDD:227565	197/949 (21%)
		HEAT repeat	402..427	CDD:293787	4/25 (16%)
		HEAT repeat	439..465	CDD:293787	4/27 (15%)
		HEAT repeat	475..505	CDD:293787	6/29 (21%)
		HEAT repeat	512..538	CDD:293787	10/27 (37%)
		COP-gamma_platf	620..761	CDD:285908	33/165 (20%)
		Coatomer_g_Cpla	763..877	CDD:292991	35/134 (26%)
ap2a1	XP_009297842.1	Adaptin_N	29..591	CDD:279882	104/516 (20%)
		RIX1	141..>292	CDD:285390	33/154 (21%)
		Alpha_adaptinC2	758..861	CDD:197886	21/111 (19%)
		Alpha_adaptin_C	867..979	CDD:280460	33/128 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910