DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gammaCOP and Copg2

DIOPT Version :9

Sequence 1:	NP_001263145.1	Gene:	gammaCOP / 43717	FlyBaseID:	FBgn0028968	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	XP_036022186.1	Gene:	Copg2 / 54160	MGIID:	1858683	Length:	908	Species:	Mus musculus

Alignment Length:	868	Identity:	518/868 - (59%)
Similarity:	665/868 - (76%)	Gaps:	17/868 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 SNAYQNLEKTSVLQETRTFNETPVNPRKCIHILTKILYLINQGEQLVAREATDCFFAMTKLFQSK 80
            ||.:|:|||::||||.|.|||||:|||:|:|||||||||:||||.....|||:.|||||:||||.
Mouse    53 SNPFQHLEKSAVLQEARIFNETPINPRRCLHILTKILYLLNQGEHFGTMEATEAFFAMTRLFQSN 117

  Fly    81 DVVLRRMVYLGIKELSSIAEDVIIVTSSLTKDMTGKEDLYRAAAIRALCSITDNTMLQAVERYMK 145
            |..||||.||.|||:::|:|||||||||||||||||||:||..||||||.|||.|||||||||||
Mouse   118 DQTLRRMCYLTIKEMATISEDVIIVTSSLTKDMTGKEDVYRGPAIRALCRITDGTMLQAVERYMK 182

  Fly   146 QCIVDKNAAVSCAALVSSLRLANTAGDVVKRWANEAQEALNSDNIMVQYHALGLLYHIRKSDRLA 210
            |.||||.::|:.:||||||.:...:.||||||.||||||.:||||||||||||:|||:||:||||
Mouse   183 QAIVDKVSSVASSALVSSLHMMKISYDVVKRWINEAQEAASSDNIMVQYHALGVLYHLRKNDRLA 247

  Fly   211 VSKLVNKLTRGSLKSPYAVCMLIRIACKLIEEEDIPSEELSDSPLFTFIESCLRHKSEMVIYEAA 275
            |||::||.|:..|||.:|.|||||||.:|::|    ||:..:||||.|||||||:|.||||||||
Mouse   248 VSKMLNKFTKSGLKSQFAYCMLIRIASRLLKE----SEDGHESPLFDFIESCLRNKHEMVIYEAA 308

  Fly   276 HAIVNLKNTNPRMLSPAFSILQLFCSSPKATLRFAAVRTLNKVAMTHPAAVTTCNLDLEGLITDS 340
            .||::|.|...|.|:||.|:|||||||||..||:|||||||||||.||:|||.||||||.|||||
Mouse   309 SAIIHLPNCTARELAPAVSVLQLFCSSPKPALRYAAVRTLNKVAMKHPSAVTACNLDLENLITDS 373

  Fly   341 NRSVATLAITTLLKTGAESSVERLMKQISTFVAEISDEFKVVVVQAICALCTKYPRKHTVLMNFL 405
            |||:||||||||||||:||||:|||||||:||:||||||||||||||.|||.||||||:|:|.||
Mouse   374 NRSIATLAITTLLKTGSESSVDRLMKQISSFVSEISDEFKVVVVQAISALCHKYPRKHSVMMTFL 438

  Fly   406 SGMLREEGGLEYKTSIVDTIITIIEENADAKESGLSHLCEFIEDCEHVSLAVRILHLLGKEGPFA 470
            |.|||::||.|||.:|||.||:|:|||.::||:||:|||||||||||..||.:||||||||||..
Mouse   439 SNMLRDDGGFEYKKAIVDCIISIVEENPESKEAGLAHLCEFIEDCEHTVLATKILHLLGKEGPRT 503

  Fly   471 ATPSKYIRFIYNRVILESPIVRAAAVTAMAQFGASCPALLSNILVLLGRCQMDPDDEVRDRATYY 535
            ..||||||||:|||:||:..||||||:|:|:|||...:||.:|||||.||.||.|||||||||:|
Mouse   504 PVPSKYIRFIFNRVVLENEAVRAAAVSALAKFGAQNESLLPSILVLLQRCMMDTDDEVRDRATFY 568

  Fly   536 LSILNSERPELYKNYIIERENCSLALLEKSLVEHLNGDVDTRFDISIVPKAAIVKPVI--ANDVM 598
            |::|...:..|...||......|:..:||:|.::.....:..||:..:|.|  :.||.  .:::.
Mouse   569 LNVLQQRQMALNATYIFNGLTVSIPGMEKALHQYTLEPSEKPFDMKSIPLA--MAPVFEQKSEIT 631

  Fly   599 LVTSSAPRPPKI--TREEESAARLAQLPGIQVLGPIHRSTAPIQLTESETEYTVQCIKHIFGQHV 661
            |||   |:|.|:  :|::....:||.:|....|||:.:|:.|:||||:||||.|:|:||:|..|:
Mouse   632 LVT---PKPEKLAPSRQDIFQEQLAAIPEFMNLGPLFKSSEPVQLTEAETEYFVRCVKHMFTDHI 693

  Fly   662 VFQFDCLNTLSDQILENVRVELTLPEGFTTRAVIPCPKLPYNDLQTTFVIVEFPPDAANSIA-TF 725
            ||||||.|||:||:||.|.|::...:.:.....||.|.||||.....:.:|..|.:...::| ||
Mouse   694 VFQFDCTNTLNDQLLEKVTVQMEPSDSYEVLCCIPAPSLPYNQPGICYTLVRLPDEDPTAVAGTF 758

  Fly   726 GATLRFVVKDCDPNTGEPESEEGYDDEYMLEDLELTVADQIQKTRKNNFQVSWDAADSEEWLQAE 790
            ..|::|.|:|||||||.|: |:||||||:|||||:||:|.|||..|.||..:|:  :..:..:.|
Mouse   759 SCTMKFTVRDCDPNTGVPD-EDGYDDEYVLEDLEVTVSDHIQKILKPNFAAAWE--EVGDAFEKE 820

  Fly   791 DTFVLSAVTTLQDAVNTIVKILGLGAANLSENVPEGTHLHTLLCSGTFRGGAEILVRAKLALSEG 855
            :||.||:..||::|||.|:..||:.....|:.|||..:.|:|..:|.:|||.::|||::|||::|
Mouse   821 ETFALSSTKTLEEAVNNIITFLGMQPCERSDKVPENKNSHSLYLAGVYRGGYDLLVRSRLALADG 885

  Fly   856 VTLNLTVRSTDQDVAELITAAIG 878
            ||:.:||||.::...::|.|::|
Mouse   886 VTMQVTVRSKERTPVDVILASVG 908

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gammaCOP	NP_001263145.1	SEC21	11..877	CDD:227565	517/865 (60%)
		HEAT repeat	402..427	CDD:293787	16/24 (67%)
		HEAT repeat	439..465	CDD:293787	20/25 (80%)
		HEAT repeat	475..505	CDD:293787	21/29 (72%)
		HEAT repeat	512..538	CDD:293787	20/25 (80%)
		COP-gamma_platf	620..761	CDD:285908	72/141 (51%)
		Coatomer_g_Cpla	763..877	CDD:292991	46/113 (41%)
Copg2	XP_036022186.1	SEC21	56..903	CDD:227565	513/858 (60%)
		HEAT repeat	325..350	CDD:293787	19/24 (79%)
		HEAT repeat	360..391	CDD:293787	27/30 (90%)
		HEAT repeat	400..422	CDD:293787	19/21 (90%)
		HEAT repeat	435..460	CDD:293787	16/24 (67%)
		HEAT repeat	472..498	CDD:293787	20/25 (80%)
		HEAT repeat	508..538	CDD:293787	21/29 (72%)
		HEAT repeat	545..571	CDD:293787	20/25 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835507
Domainoid	1	1.000	734	1.000	Domainoid score	I103
eggNOG	1	0.900	-	-		E1_COG5240
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56292
Inparanoid	1	1.050	1010	1.000	Inparanoid score	I287
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53896
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002163
OrthoInspector	1	1.000	-	-		otm42957
orthoMCL	1	0.900	-	-		OOG6_101348
Panther	1	1.100	-	-	LDO	PTHR10261
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R230
SonicParanoid	1	1.000	-	-		X1625
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.790