DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gammaCOP and ap2b1

DIOPT Version :9

Sequence 1:	NP_001263145.1	Gene:	gammaCOP / 43717	FlyBaseID:	FBgn0028968	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	XP_012812114.1	Gene:	ap2b1 / 394814	XenbaseID:	XB-GENE-5871354	Length:	958	Species:	Xenopus tropicalis

Alignment Length:	944	Identity:	162/944 - (17%)
Similarity:	337/944 - (35%)	Gaps:	229/944 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 VAREATDCFFAMTKLFQSKDVVLRRMVYLGIKELSSIAEDV-IIVTSSLTKDMTGKEDLYRAAAI 125
            |.::.:..|..:....|:.::.|:::|||.:...:....|: |:..:|..||......|.||.|:
Frog    43 VGKDVSSLFPDVVNCMQTDNLELKKLVYLYLMNYAKSQPDMAIMAVNSFVKDCEDPNPLIRALAV 107

  Fly   126 RALCSITDNTMLQAVERYMKQCIVDKNAAVSCAALVSSLRLANTAGDVV--KRWANEAQEALNSD 188
            |.:..|..:.:.:.:...:::|:.|::..|...|.|...:|.:....:|  :.:.:..::.:...
Frog   108 RTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQMVEDQGFLDSLRDLIADS 172

  Fly   189 NIMVQYHALGLLYHIRKSDRLAVSKLVNKLTRGSLKSPYAVCMLIRIACKLIEEEDI-------- 245
            |.||..:|:..|..|.:|.  ..|.|::       .:|..:..|:....:..|...|
Frog   173 NPMVVANAVAALSEISESH--PNSNLLD-------LNPQNINKLLTALNECTEWGQIFILDCLSN 228

  Fly   246 --PSEELSDSPLFTFIESCLRHKSEMVIYEAAHAIVNLKNTNPRMLSPAFSILQLFCSSPKATL- 307
              |.:|.....:...:...|.|.:..|:..|...::......|:. |..:::|....:.|..||
Frog   229 YNPKDEREAQSICERVTPRLSHANSAVVLSAVKVLMKFLELLPKD-SDYYTMLLKKLAPPLVTLL 292

  Fly   308 ------RFAAVRTLNKVAMTHPAAVTTCNLDLEGLITDSNRS--VATLAITTLLKTGAESSVERL 364
                  ::.|:|.:|.:....|..:   ..:::......|..  |....:..:::..:::::.::
Frog   293 SGEPEVQYVALRNINLIVQKRPEIL---KQEIKVFFVKYNDPIYVKLEKLDIMIRLASQANIAQV 354

  Fly   365 MKQISTFVAEISDEFKVVVVQAI--CALCTKYPRKHTVLMNFLSGMLREEGGLEYKTSIVDTIIT 427
            :.::..:..|:..:|....|:||  ||:..:...:..|  :.|..:::.:.....:.:|| .|..
Frog   355 LAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCV--STLLDLIQTKVNYVVQEAIV-VIRD 416

  Fly   428 IIEENADAKESGLSHLCEFIEDCEHVSLAVRILHLLGKEGPFAATPSKYIRFIYNRVILESPIVR 492
            |..:..:..||.::.|||.::..:.......::.::|:.........:.:.........||..|:
Frog   417 IFRKYPNKYESIIATLCENLDSLDEPDARGAMIWIVGEYAERIDNADELLESFLEGFHDESTQVQ 481

  Fly   493 AAAVTAMAQFGASCPA----LLSNILVLLGRCQMDPDDEVRDRATYYLSILN-----------SE 542
            ...:||:.:.....|:    |:..:|.|..:...:||  :|||...|..:|:           ||
Frog   482 LTLLTAIVKLFLKKPSETQELVQQVLSLATQDSDNPD--LRDRGYIYWRLLSTDPVTAKEVVLSE 544

  Fly   543 RP------ELYKNYIIERENCSLALL-------EKSLVE--------HL---NGDVDT-RFDISI 582
            :|      :|.:..:::...|.:..|       ..:.||        ||   :|.:|. ...:..
Frog   545 KPLISEETDLIEPTLLDELICHIGSLASVYHKPPNAFVEGSHGVHRKHLPIQHGSIDIGDSPVGP 609

  Fly   583 VPKAAIVKPVI-------------------------------ANDVM------------------ 598
            .|.|.:.:|.:                               |.|::
Frog   610 TPSAGLEQPQVIPSQGDLLGDLLNLDLGPPGNVPQVSTMQMGAVDLLGGGLDSLMGEDTQWLGSD 674

  Fly   599 --------------LVTSS-----APRP-PKITR-------EEESAARLAQ----------LP-- 624
                          .:.||     ||.| |.:..       |..|...:|.          ||
Frog   675 LGGGIGGSPAVGQTFIPSSVPATFAPSPTPAVVSSGLNDLFELSSGIGMAPGGYVSQKAVWLPAV 739

  Fly   625 ---GIQVLGPIHRSTAPIQLTES--------ETEYTVQCIKHIFGQHVVFQFDCLNTLSDQILEN 678
               |:::.|......|.|.:..|        .|::.:|..|:.||   |.....| .:...::.|
Frog   740 KAKGLEISGTFSHRQAHIYMDMSFTNKALQHMTDFAIQFNKNSFG---VIPSAPL-AIHTPLMPN 800

  Fly   679 VRVELTLPEGFTTRAVIPCPKL-PYNDLQTTF--------------VIVEFPPDAANSIATFGAT 728
            ..::::||    ...:.|..|: |.|:||...              :.|.|..|.......|.||
Frog   801 QSIDISLP----LNTLGPVMKMEPLNNLQVAVKNNIDVFYFSCLIPLHVLFVEDGKMERQVFLAT 861

  Fly   729 ---------LRFVVKDCDPNTGEPESEEGYDDEYMLEDLELTVADQIQKTRKNNFQVSWDAADSE 784
                     |:|.:|||..|.....|:...::.|.:....:...|.:.::.|....:
Frog   862 WKDIPNENELQFQIKDCHLNADTVSSKLQNNNVYTIAKRNVEGQDMLYQSLKLTNGI-------- 918

  Fly   785 EWLQAE-------DTFVLSAVTTLQDAVNTIVKI 811
             |:.||       ..:.||......:..|.:.::
Frog   919 -WILAELRIQPGNPNYTLSLKCRAPEVCNYVYQV 951

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gammaCOP	NP_001263145.1	SEC21	11..877	CDD:227565	162/944 (17%)
		HEAT repeat	402..427	CDD:293787	4/24 (17%)
		HEAT repeat	439..465	CDD:293787	3/25 (12%)
		HEAT repeat	475..505	CDD:293787	5/29 (17%)
		HEAT repeat	512..538	CDD:293787	8/25 (32%)
		COP-gamma_platf	620..761	CDD:285908	38/187 (20%)
		Coatomer_g_Cpla	763..877	CDD:292991	8/56 (14%)
ap2b1	XP_012812114.1	Adaptin_N	11..534	CDD:366724	91/508 (18%)
		HEAT repeat	51..75	CDD:293787	6/23 (26%)
		HEAT repeat	87..114	CDD:293787	8/26 (31%)
		HEAT repeat	121..151	CDD:293787	6/29 (21%)
		HEAT repeat	160..186	CDD:293787	5/25 (20%)
		HEAT repeat	197..228	CDD:293787	4/37 (11%)
		HEAT repeat	392..416	CDD:293787	5/26 (19%)
		HEAT repeat	428..457	CDD:293787	4/28 (14%)
		HEAT repeat	464..494	CDD:293787	5/29 (17%)
		HEAT repeat	505..541	CDD:293787	9/37 (24%)
		Alpha_adaptinC2	738..838	CDD:197886	21/107 (20%)
		B2-adapt-app_C	847..957	CDD:198088	21/114 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910