DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gammaCOP and ap2b1

DIOPT Version :9

Sequence 1:	NP_001263145.1	Gene:	gammaCOP / 43717	FlyBaseID:	FBgn0028968	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	NP_956213.2	Gene:	ap2b1 / 334632	ZFINID:	ZDB-GENE-030131-6564	Length:	951	Species:	Danio rerio

Alignment Length:	897	Identity:	161/897 - (17%)
Similarity:	328/897 - (36%)	Gaps:	228/897 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 VAREATDCFFAMTKLFQSKDVVLRRMVYLGIKELSSIAEDV-IIVTSSLTKDMTGKEDLYRAAAI 125
            |.::.:..|..:....|:.::.|:::|||.:...:....|: |:..:|..||......|.||.|:
Zfish    43 VGKDVSSLFPDVVNCMQTDNLELKKLVYLYLMNYAKSQPDMAIMAVNSFVKDCEDPNPLIRALAV 107

  Fly   126 RALCSITDNTMLQAVERYMKQCIVDKNAAVSCAALVSSLRLANTAGDVV--KRWANEAQEALNSD 188
            |.:..|..:.:.:.:...:::|:.|::..|...|.|...:|.:....:|  :.:.:..::.:...
Zfish   108 RTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQMVEDQGFLDSLRDLIADS 172

  Fly   189 NIMVQYHALGLLYHIRKSDRLAVSKLVNKLTRGSLKSPYAVCMLIRIACKLIEEEDI-------- 245
            |.||..:|:..|..|.:|.  ..|.|::       .:|..:..|:....:..|...|
Zfish   173 NPMVVANAVAALSEISESH--PNSNLLD-------LNPQNINKLLTALNECTEWGQIFILDCLSN 228

  Fly   246 --PSEELSDSPLFTFIESCLRHKSEMVIYEAAHAIV----------NLKNTNPRMLSPAFSILQL 298
              |.:|.....:...:...|.|.:..|:..|...::          :..||..:.|||  .::.|
Zfish   229 YNPKDEREAQSICERVTPRLSHANSAVVLSAVKVLMKFLELLPKDSDYYNTLLKKLSP--PLVTL 291

  Fly   299 FCSSPKATLRFAAVRTLNKVAMTHPAAVTTCNLDLEGLITDSNRS--VATLAITTLLKTGAESSV 361
            ....|:  :::.|:|.:|.:....|..:   ..:::......|..  |....:..:::..:.:::
Zfish   292 LSGEPE--VQYVALRNINLIVQKRPEIL---KQEIKVFFVKYNDPIYVKLEKLDIMIRLASHANI 351

  Fly   362 ERLMKQISTFVAEISDEFKVVVVQAI--CALCTKYPRKHTVLMNFLSGMLREEGGLEYKTSIVDT 424
            .:::.::..:..|:..:|....|:||  ||:..:...:..|  :.|..:::.:.....:.:|| .
Zfish   352 AQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCV--STLLDLIQTKVNYVVQEAIV-V 413

  Fly   425 IITIIEENADAKESGLSHLCEFIEDCEHVSLAVRILHLLGKEGPFAATPSKYIRFIYNRVILESP 489
            |..|..:..:..||.::.|||.::..:.......::.::|:.........:.:.........||.
Zfish   414 IRDIFRKYPNKYESIIATLCENLDSLDEPDARGAMIWIVGEYAERIDNADELLESFLEGFHDEST 478

  Fly   490 IVRAAAVTAMAQFGASCPA----LLSNILVLLGRCQMDPDDEVRDRATYYLSILN---------- 540
            .|:...:||:.:.....|:    |:..:|.|..:...:||  :|||...|..:|:
Zfish   479 QVQLTLLTAIVKLFLKKPSETQELVQQVLSLATQDSDNPD--LRDRGYIYWRLLSTDPVTAKEVV 541

  Fly   541 -SERP------ELYKNYIIERENCSLALL-------EKSLVE--------HL---NGDVDT-RFD 579
             ||:|      :|.:..:::...|.:..|       ..:.||        ||   :|.:|| ...
Zfish   542 LSEKPLISEETDLIEPTLLDELICHIGSLASVYHKPPNAFVEGSHGIHRKHLPIQHGSIDTGESP 606

  Fly   580 ISIVPKAAIVKP-------------------------------VIANDVM--------------- 598
            :|..|.|:|.:|                               :.|.|::
Zfish   607 VSTGPAASIDQPQVIPSQGDLLGDLLNLDLGPPVNVPQVSSMQIAAVDLLGGGLDSLLGGDLGGG 671

  Fly   599 ----------LVTSSAPR--PPKITREEES---------------------AARLAQLP-----G 625
                      .:.||.|.  .|..|....|                     ||:...||     |
Zfish   672 VGGSPAVGQNFIPSSVPNTFAPSPTPAALSSGLNDLFELSTGMATATGGYVAAKTVWLPAVKAKG 736

  Fly   626 IQVLGPIHR--------STAPIQLTESETEYTVQCIKHIFGQHVVFQFDCLNTLSDQILENVRVE 682
            :::.|...|        .|...:..:..|::.:|..|:.||   |.....| .:...::.:..::
Zfish   737 LEISGTFSRRQGHMYMDMTFTNKALQHMTDFAIQFNKNSFG---VIPTTPL-PVHTPLMPSQSID 797

  Fly   683 LTLPEGFTTRAVIPCPKL-PYNDLQTTF--------------VIVEFPPDAANSIATFGAT---- 728
            ::||    ...:.|..|: |.|:||...              :.|.|..|.......|.||
Zfish   798 ISLP----LNTIGPVMKMDPLNNLQVAVKNNIDVFYFSTLIPLNVFFVEDGKMERQVFLATWKDI 858

  Fly   729 -----LRFVVKDC----DPNTGEPESE----------EGYDDEYMLEDLELT 761
                 |::.:|||    |..:|:.:|.          ||.|..|  :.|:||
Zfish   859 PNENELQYQIKDCHLNADTVSGKLQSNNVYTIAKRNVEGQDMLY--QSLKLT 908

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gammaCOP	NP_001263145.1	SEC21	11..877	CDD:227565	161/897 (18%)
		HEAT repeat	402..427	CDD:293787	4/24 (17%)
		HEAT repeat	439..465	CDD:293787	3/25 (12%)
		HEAT repeat	475..505	CDD:293787	5/29 (17%)
		HEAT repeat	512..538	CDD:293787	8/25 (32%)
		COP-gamma_platf	620..761	CDD:285908	39/191 (20%)
		Coatomer_g_Cpla	763..877	CDD:292991
ap2b1	NP_956213.2	Adaptin_N	11..534	CDD:279882	92/511 (18%)
		HEAT repeat	15..42	CDD:293787
		HEAT repeat	51..75	CDD:293787	6/23 (26%)
		HEAT repeat	87..114	CDD:293787	8/26 (31%)
		Cnd1	99..268	CDD:289487	32/177 (18%)
		HEAT repeat	121..151	CDD:293787	6/29 (21%)
		HEAT repeat	160..186	CDD:293787	5/25 (20%)
		HEAT repeat	197..228	CDD:293787	4/37 (11%)
		HEAT repeat	392..416	CDD:293787	5/26 (19%)
		HEAT repeat	428..457	CDD:293787	4/28 (14%)
		HEAT repeat	464..494	CDD:293787	5/29 (17%)
		HEAT repeat	505..541	CDD:293787	9/37 (24%)
		Alpha_adaptinC2	731..831	CDD:197886	19/107 (18%)
		B2-adapt-app_C	840..950	CDD:198088	19/71 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910