DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gammaCOP and AP-1-2beta

DIOPT Version :9

Sequence 1:	NP_001263145.1	Gene:	gammaCOP / 43717	FlyBaseID:	FBgn0028968	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	NP_523415.1	Gene:	AP-1-2beta / 32987	FlyBaseID:	FBgn0010380	Length:	921	Species:	Drosophila melanogaster

Alignment Length:	790	Identity:	142/790 - (17%)
Similarity:	301/790 - (38%)	Gaps:	177/790 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 VAREATDCFFAMTKLFQSKDVVLRRMVYLGIKELSSIAEDV-IIVTSSLTKDMTGKEDLYRAAAI 125
            |.::.:..|..:....|:.::.|:::|||.:...:....|: |:..::..||......|.||.|:
  Fly    43 VGKDVSALFPDVVNCMQTDNLELKKLVYLYLMNYAKSQPDMAIMAVNTFVKDCEDSNPLIRALAV 107

  Fly   126 RALCSITDNTMLQAVERYMKQCIVDKNAAVSCAALVSSLRLANTAGDVV--KRWANEAQEALNSD 188
            |.:..|..:.:.:.:...:::|:.|::..|...|.|...:|.:.:..:|  :.:.::.::.|:..
  Fly   108 RTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLYDISATMVEDQGFLDQLKDLLSDS 172

  Fly   189 NIMVQYHALGLLYHIRKSDR----------LAVSKL---VNKLTRGSLKSPYAVCMLIRIACKLI 240
            |.||..:|:..|..|.::.:          :.::||   :|:.|...     .|.:|..:|
  Fly   173 NPMVVANAVAALSEINEASQSGQPLVEMNSVTINKLLTALNECTEWG-----QVFILDSLA---- 228

  Fly   241 EEEDIPSEELSDSPLFTFIESCLRHKSEMVIYEAAHAIVNLKN----------TNPRMLSPAFSI 295
              ...|.:|.....:...|...|.|.:..|:..|...::.|..          |..:.|:|  .:
  Fly   229 --NYSPKDEREAQSICERITPRLAHANAAVVLSAVKVLMKLLEMLSSDSDFCATLTKKLAP--PL 289

  Fly   296 LQLFCSSPKATLRFAAVRTLNKVAMTHPAAVTTCNLDLEGLITDSNRS--VATLAITTLLKTGAE 358
            :.|..|.|:  :::.|:|.:|.:....|..:   ..:::......|..  |....:..:::...:
  Fly   290 VTLLSSEPE--VQYVALRNINLIVQKRPDIL---KHEMKVFFVKYNDPIYVKLEKLDIMIRLANQ 349

  Fly   359 SSVERLMKQISTFVAEISDEFKVVVVQAI--CALCTKYPRKHTVLMNFLSGMLREEGGLEYKTSI 421
            |::.:::.::..:..|:..:|....|:||  ||:..:...:..|  :.|..:::.:.....:.:|
  Fly   350 SNIAQVLSELKEYATEVDVDFVRKAVRAIGRCAIKVEPSAERCV--STLLDLIQTKVNYVVQEAI 412

  Fly   422 VDTIITIIEENADAKESGLSHLCEFIEDCEHVSLAVRILHLLGKEGPFAATPSKYIRFIYNRVIL 486
            | .|..|..:..:..||.:|.|||.::..:.......::.::|          :|...|.|...|
  Fly   413 V-VIKDIFRKYPNKYESIISTLCENLDTLDEPEARASMVWIIG----------EYAERIDNADEL 466

  Fly   487 ----------ESPIVRAAAVTAMAQFGASCPA----LLSNILVLLGRCQMDPDDEVRDRATYYLS 537
                      |:..|:...:||:.:.....|:    |:.::|.|..:...:||  :|||...|..
  Fly   467 LDSFLEGFQDENAQVQLQLLTAVVKLFLKRPSDTQELVQHVLSLATQDSDNPD--LRDRGFIYWR 529

  Fly   538 ILNSERPELYKNYIIERENCSLALLEKSLVEHLNGDVDTRFDISIVPKAAIVKPVIANDVMLVTS 602
            :|::: |...|..:         |.:|.|:..               :..:::|.:.::::...|
  Fly   530 LLSTD-PAAAKEVV---------LADKPLISE---------------ETDLLEPTLLDELICHIS 569

  Fly   603 SAP----RPPKITREEESAARLAQLPGIQVLGPIHRSTAPIQLTESETEYTVQCIKHIFGQHVVF 663
            |..    :||....|...|.....||. :..|    |.|..:..|
  Fly   570 SLASVYHKPPTAFVEGRGAGVRKSLPN-RAAG----SAAGAEQAE-------------------- 609

  Fly   664 QFDCLNTLSDQILENVRVELTLPEGFTTRAVIPCPKLPYNDLQTTFV---IVEFPPDAANSIATF 725
                 |....:.:                 |||..:....||.:..:   .:...|.|.:::...
  Fly   610 -----NAAGSEAM-----------------VIPNQESLIGDLLSMDINAPAMPSAPAATSNVDLL 652

  Fly   726 GATLRFVVKDCDPNTGEPESEEG-------YDDEYMLEDLELTVADQIQKTRKNNFQVSWDAADS 783
            |..|..::       |.|.:|..       ..|.:.|....|:|..||.|       |:|..|:.
  Fly   653 GGGLDILL-------GGPPAEAAPGGATSLLGDIFGLGGATLSVGVQIPK-------VTWLPAEK 703

  Fly   784 EEWLQAEDTF 793
            .:.|:.:.||
  Fly   704 GKGLEIQGTF 713

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gammaCOP	NP_001263145.1	SEC21	11..877	CDD:227565	142/790 (18%)
		HEAT repeat	402..427	CDD:293787	4/24 (17%)
		HEAT repeat	439..465	CDD:293787	4/25 (16%)
		HEAT repeat	475..505	CDD:293787	8/39 (21%)
		HEAT repeat	512..538	CDD:293787	8/25 (32%)
		COP-gamma_platf	620..761	CDD:285908	21/150 (14%)
		Coatomer_g_Cpla	763..877	CDD:292991	9/31 (29%)
AP-1-2beta	NP_523415.1	Adaptin_N	38..535	CDD:279882	98/525 (19%)
		HEAT repeat	51..75	CDD:293787	6/23 (26%)
		HEAT repeat	87..114	CDD:293787	7/26 (27%)
		Cnd1	99..269	CDD:289487	35/180 (19%)
		HEAT repeat	121..151	CDD:293787	6/29 (21%)
		HEAT repeat	160..186	CDD:293787	6/25 (24%)
		HEAT repeat	197..229	CDD:293787	7/42 (17%)
		HEAT repeat	393..417	CDD:293787	5/26 (19%)
		HEAT repeat	429..458	CDD:293787	6/38 (16%)
		HEAT repeat	465..495	CDD:293787	5/29 (17%)
		HEAT repeat	506..542	CDD:293787	11/38 (29%)
		Alpha_adaptinC2	703..799	CDD:197886	3/11 (27%)
		B2-adapt-app_C	809..919	CDD:198088
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910