DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gammaCOP and betaCOP

DIOPT Version :9

Sequence 1:	NP_001263145.1	Gene:	gammaCOP / 43717	FlyBaseID:	FBgn0028968	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	NP_523400.1	Gene:	betaCOP / 32820	FlyBaseID:	FBgn0008635	Length:	964	Species:	Drosophila melanogaster

Alignment Length:	860	Identity:	148/860 - (17%)
Similarity:	298/860 - (34%)	Gaps:	207/860 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 NLEKTSVLQETRTFNETPVNPRKCIHILTKILYLINQGEQLVAREATDCFFAMTKLFQSKDVVLR 85
            :||.|:.:|..|...:...|.:  |..|.:::.|:..||:......|...|.:.  .|:..:...
  Fly    15 DLEVTNEMQLKRDLEKGDTNVK--IETLKRVIKLLLNGERYPGLIMTIIRFVLP--VQNHTIKKL 75

  Fly    86 RMVYLGIKELSS----IAEDVIIVTSSLTKDMTGKEDLYRAAAIRALCSITDNTMLQAVERYMKQ 146
            .:::..|...:|    :.:::|:|..:..||:....:..|.:.:|.||.:.:..:|:.:...::.
  Fly    76 LLIFWEIVPKTSADGKLLQEMILVCDAYRKDLQHPNEFLRGSTLRFLCKLKEPELLEPLMPAIRA 140

  Fly   147 CI------VDKNAAVSCAALVSSL------------RLANTAGDV-VKRWA------NEAQEALN 186
            |:      |.:||.::...:..:.            ...:|..|: .||.|      .:.:.|||
  Fly   141 CLDHRHSYVRRNAVLAIFTIYKNFDWLVPDGPELIASFLDTQQDMSCKRNAFLMLLHADQERALN 205

  Fly   187 -SDNIMVQYHALGLLYHIRKSDRLAVSKLVNKLTRGSLKSPYAVCMLIRIACKLIEEEDIPSEEL 250
             ..:.:.|.|..|.:.      :|.:.:|:           |.||            ...|:|.
  Fly   206 YLASCIDQVHTFGDIL------QLVIVELI-----------YKVC------------HANPAER- 240

  Fly   251 SDSPLFTFIESCLRHKSEMVIYEAAHAIVNLKNTNPRMLSPAFSILQLFCSSPKATLRFAAVRTL 315
              |.....|.:.|...|..|.||:|..::.|
  Fly   241 --SRFIRCIYNLLNSSSNAVRYESAGTLITL---------------------------------- 269

  Fly   316 NKVAMTHPAAVTTCNLDLEGLITDSNRSVATLAITTLLKTGAESSVERLMKQISTFVAEISDEFK 380
             .:|.|...|..:|.::|  ::.:|:.:|..:.:..|:.......:|::|:.:      :.|..:
  Fly   270 -SLAPTAIKAAASCYIEL--VVKESDNNVKLIVLDRLVAMKEHEGMEKVMQDL------VMDVLR 325

  Fly   381 VVVVQAI--------CALCTKYPRKHTVLMNFLSGMLREEGGLE------YKTSIVDTIITIIEE 431
            |:....|        .||...|.|....::..|...:.:...:|      |:..:|.|:.|...:
  Fly   326 VLAAPDIEVRRKTLALALDLVYSRNIGEMVLVLKKEVAKTHNVEHEDTGKYRQLLVRTLHTCSIK 390

  Fly   432 NADAKESGLSHLCEFIEDCEHVSLAVRILHLLGKEGPFAATPSKYIRFIYNRV-ILESPIVRAAA 495
            ..|...:.:..|.||:.|...::.|..::.:......|.|..:..|..:.... .::|..:..||
  Fly   391 FPDVAANVIPVLVEFLSDTNELAAADVLIFIREAIQKFPALRALIIEHLIEAFPQIKSSKIHRAA 455

  Fly   496 VTAMAQF--GASCPALLSNILVLLGRCQMDPDDEVRDRATYYLSILNSERPELYKNYIIERENCS 558
            |..:.::  |:....:::.|...||...|...::.|         |..::.|..|    :::..:
  Fly   456 VWILGEYVEGSQILEVIAVIQQTLGEVPMVEAEQRR---------LAGDQTEEQK----QQQGSA 507

  Fly   559 LALLEKSLVEHL-NGDVDTRFDISIVPKAAIVKPVIANDVMLVTSSA-PRPPKITREEESAARLA 621
            ......|..|.. :|:...:               :.:|....|.|| ...|....|:....|..
  Fly   508 GGNAAGSAAEGSGSGNASNK---------------VTSDGTYATQSAYSLAPVAKAEKRPPLRQY 557

  Fly   622 QLPGIQVLGPIHRST---APIQLTESETEYTVQCIKHIFGQHVVFQFDCLNTLSDQILENVRVEL 683
            .:.|...:|....:|   ..::..|.|||...|                 |.|:.|::..:...|
  Fly   558 LMDGDFFIGAALSATLTKLALRYAELETEARAQ-----------------NRLTTQVMLIMSSIL 605

  Fly   684 TL-PEGFTTRAVIPCPKLPYNDLQTTFV----IVEFPPDAANSIATFGATLRFVVKDCDPNTGEP 743
            .| ..||      |...:..:|....||    :.|..|:|.:....:          |....|:.
  Fly   606 HLGKSGF------PSKPITNDDTDRIFVCLRTLSERTPEAISVFTLY----------CREALGKM 654

  Fly   744 ESEEGYDDEYMLEDLELTVAD----------QIQKTRKNNFQVSWDAADSEEWLQAEDTFVLSAV 798
            ...:..:|:.||::.:...|.          |:...|.|....:...:...:.|.......||.|
  Fly   655 LDAQHDEDQRMLKEKQKATAKVQPDDPVLFAQLSNGRDNQLGENVFESSLNQALAGSKNAQLSDV 719

  Fly   799 TTLQDAVNTIVKILG 813
            .:....:|.:.::.|
  Fly   720 ASPNSKLNKVTQLTG 734

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gammaCOP	NP_001263145.1	SEC21	11..877	CDD:227565	148/860 (17%)
		HEAT repeat	402..427	CDD:293787	5/30 (17%)
		HEAT repeat	439..465	CDD:293787	5/25 (20%)
		HEAT repeat	475..505	CDD:293787	6/32 (19%)
		HEAT repeat	512..538	CDD:293787	5/25 (20%)
		COP-gamma_platf	620..761	CDD:285908	27/148 (18%)
		Coatomer_g_Cpla	763..877	CDD:292991	10/61 (16%)
betaCOP	NP_523400.1	Adaptin_N	17..562	CDD:279882	110/651 (17%)
		Coatamer_beta_C	678..820	CDD:285019	9/57 (16%)
		Coatomer_b_Cpla	826..953	CDD:291472
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910