DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gammaCOP and ap1g1

DIOPT Version :9

Sequence 1:	NP_001263145.1	Gene:	gammaCOP / 43717	FlyBaseID:	FBgn0028968	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	XP_017212304.1	Gene:	ap1g1 / 324466	ZFINID:	ZDB-GENE-030131-3187	Length:	822	Species:	Danio rerio

Alignment Length:	815	Identity:	153/815 - (18%)
Similarity:	310/815 - (38%)	Gaps:	190/815 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 KTSVLQETRTFNETPVNPRKCIHILTKILYLINQG-----EQLVAREATDCFFAMTKLFQSKDVV 83
            ::|..:|..|:        :|.:: .|:||:...|     .||      :|.    ||..|:...
Zfish    35 RSSFREEDNTY--------RCRNV-AKLLYMHMLGYPAHFGQL------ECL----KLIASQKFT 80

  Fly    84 LRRMVYLGIKELSSIAEDV-IIVTSSLTKDMTGKEDLYRAAAIRALCSITDNTMLQAVERYMKQC 147
            .:|:.|||...|....:|| :::|:.:..|:.......:..|:..|..:..:.|.:.:...:::.
Zfish    81 DKRIGYLGAMLLLDERQDVHLLMTNCIKNDLNHSTQYVQGLALCTLGCMGSSEMCRDLAGEVEKL 145

  Fly   148 IVDKNAAVSCAALVSSLRLANTAGDVVKRWANEAQEALNSDNIMVQYHAL-----------GLLY 201
            :...|:.:...|.:.::.:.....::::.:....:..|:..|..|.:.::           .:|.
Zfish   146 LKTSNSYLRKKAALCAVHVIRKVPELMEMFLPATKNLLSEKNHGVLHTSVVLLTEMCERSPDMLS 210

  Fly   202 HIRKSDRLA---VSKLVNKLTRG--------SLKSPYAVCMLIRIACKLIEEEDIPSEELSD--S 253
            |.||:::|.   |..|.|.:..|        .:..|:....::|:...|.:.:|..||.::|  :
Zfish   211 HFRKNEKLVPQLVRILKNLIMSGYSPEHDVSGISDPFLQVRILRLLRILGKGDDDSSEAMNDILA 275

  Fly   254 PLFTFIESCLRHKSEMVIYEAAHAIVNLKN-TNPRMLSPAFSILQLFCSSPKATLRFAAVRTLNK 317
            .:.|..|:. ::....::||....|:::|: :..|:|  |.:||..|..:....:|:.|:.:|.|
Zfish   276 QVATNTETS-KNVGNAILYETVLTIMDIKSESGLRVL--AINILGRFLLNNDKNIRYVALTSLLK 337

  Fly   318 VAMT-------HPAAVTTCNLDLEGLITDSNRSVATLAITTLLKTGAESSVERLMKQISTFVAEI 375
            ...|       |.:.:..|..||:  ::...|:   :.::..|..|  :::..:||::..|:...
Zfish   338 TVQTDHNAVQRHRSTIVDCLKDLD--VSIKRRA---MELSFALVNG--NNIRGMMKELLYFLDSC 395

  Fly   376 SDEFKVVVVQAICALCTKY-PRKH---TVLMNFLSGMLREEGGLEYKTSIVDTIITIIEENADAK 436
            ..|||......|.....|| |.|.   ..:|..|:     ..|...:...|..:|.:|..:.:..
Zfish   396 DPEFKADCASGIFLAAEKYAPSKRWHIDTIMRVLT-----TAGSYVRDDSVPNLIQLITNSVEMH 455

  Fly   437 ESGLSHLCE-FIEDCEHVSLAVRILHLLGKEG------------PFAATPSKYIRFIYNRVI--L 486
            ...:..|.: .::|.....|.......:|:.|            |...:..:.:..:...::  |
Zfish   456 AYTVQRLYKALLDDISQQPLVQVASWCIGEYGDLLVSGQCEEEEPIQVSEDEVLDVLEGLLVSNL 520

  Fly   487 ESPIVRAAAVTAMAQFGASCPAL--LSNILVLLGRCQMDPDDEVRDRATYYLSILNSERPELYKN 549
            .:|:.|..::||:.:......::  :..::.:.|   ...|.|::.||..|.:        |:|.
Zfish   521 SAPVTRGYSLTAIMKLSTRFSSVNRIKKVVSIYG---SSIDVELQQRAVEYNA--------LFKK 574

  Fly   550 Y------IIERENCSLALLEKSL------VEHLNGDVDTRFDISIVPKAAIVKPVIANDVMLVTS 602
            |      ::||    :.::|||.      :...||:.|.              |::
Zfish   575 YDHMRPALLER----MPIMEKSATNGPAEIVQTNGETDA--------------PIL--------- 612

  Fly   603 SAPRPPKITREEESAARLAQLPGIQVLGPIHRSTAPIQLTESETEYTVQCIKHIFGQHVVFQFDC 667
            ....||.|.:....|..|..|.|...:.|:.::|||.:...:..|                   .
Zfish   613 DTKHPPNIPQPISQANDLLDLLGGNDVVPVIQTTAPTKPASAGGE-------------------L 658

  Fly   668 LNTLSDQILEN-------VRVELTLP----EGFTTR-------AVIPCPKLPY--NDLQTTFVIV 712
            |:.|.|..|..       ..|.::.|    :|.|::       |.|| |...|  |.|:..|...
Zfish   659 LDLLGDLSLTGGPAPTPAPSVPMSQPPFLLDGLTSQPLFNDIGAGIP-PMTAYNKNGLKIEFTFE 722

  Fly   713 EFPPDAANSIATFGAT-------LRFVVKDCDPNT 740
            ...|:...::.|..||       ..||.:...|.|
Zfish   723 RSNPNPNIAVITIHATNTTEVDMTEFVFQAAVPKT 757

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gammaCOP	NP_001263145.1	SEC21	11..877	CDD:227565	153/815 (19%)
		HEAT repeat	402..427	CDD:293787	4/24 (17%)
		HEAT repeat	439..465	CDD:293787	3/26 (12%)
		HEAT repeat	475..505	CDD:293787	5/31 (16%)
		HEAT repeat	512..538	CDD:293787	6/25 (24%)
		COP-gamma_platf	620..761	CDD:285908	32/148 (22%)
		Coatomer_g_Cpla	763..877	CDD:292991
ap1g1	XP_017212304.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910