Protein Alignment gammaCOP and Ap3b2

DIOPT Version :9

• Sequence 1: NP_001263145.1
• Gene: gammaCOP / 43717
• FlyBaseID: FBgn0028968
• Length: 897
• Species: Drosophila melanogaster
• Sequence 2: NP_001101002.2
• Gene: Ap3b2 / 308777
• RGDID: 1308950
• Length: 1082
• Species: Rattus norvegicus
• Alignment Length: 586
• Identity: 113/586 - (19%)
• Similarity: 212/586 - (36%)
• Gaps: 155/586 - (26%)

  Fly    45 IHILTKILYLINQGEQLVAREATDCFFAMTKLFQSKDVVLRRMVYLGIKELSSIAEDVIIVT-SS 108
            :..:.:|:.:|.:|     :.|:|.|.|:.|....|::.::::||:.:...:...:|:.::: |:
  Rat    55 LEAMKRIVAMIARG-----KNASDLFPAVVKNVACKNIEVKKLVYVYLVRYAEEQQDLALLSIST 114

  Fly   109 LTKDMTGKEDLYRAAAIRALCSITDNTMLQAVERYMKQCIVD------KNAAVSCAALVS----- 162
            ..:.:.....|.||:|:|.|.||....::..:...:|:...|      |.||.:...|.|
  Rat   115 FQRGLKDPNQLIRASALRVLSSIRVPIIVPIMMLAIKEAASDMSPYVRKTAAHAIPKLYSLDSDQ 179

  Fly   163 --------SLRLAN----TAGDVVKRWANEAQEALNSDNIMVQYHAL-GLLYHIRKSDRLAVSKL 214
                    ...||:    .||.||..:.....|.:  |.|...|..| .||..:.:..::.:..:
  Rat   180 KDQLIEVIEKLLADKTTLVAGSVVMAFEEVCPERI--DLIHKNYRKLCNLLIDVEEWGQVVIISM 242

  Fly   215 VNKLTRGSLKSPYAVCMLIRIACKLIEEEDIPSEELSDSPLFTFIESCLRHKSEMVIY------- 272
            :.:..|....||                              |..||.|....|...|
  Rat   243 LTRYARTQFLSP------------------------------TQNESLLEENPEKAFYGSEEDEA 277

  Fly   273 ------EAAHAIVN--------------LKNTNP----RMLSPAFSILQL-FCSSPKATLRFAAV 312
                  |||.|.:.              |:||.|    |..:...::.|| |..:|||.:...|
  Rat   278 KGPGSEEAATAALPARKPYVMDPDHRLLLRNTKPLLQSRSAAVVMAVAQLYFHLAPKAEVGVIA- 341

  Fly   313 RTLNKVAMTHPAA-------VTTCNLDLEGLI-----------TDSNRSVATLAITTLLKTGAES 359
            :.|.::..:|...       |.|.::...|:.           ||..: :..|.:..|.....|:
  Rat   342 KALVRLLRSHSEVQYVVLQNVATMSIKRRGMFEPYLKSFYIRSTDPTQ-IKILKLEVLTNLANET 405

  Fly   360 SVERLMKQISTFVAEISDEFKVVVVQAICALCTKYPRKHTVLMNFLSGMLREEGGLEYKTSIVDT 424
            ::..::::..|::..:..:|....:|||....|...|.....:|.|..:|.....|....|:| .
  Rat   406 NIPTVLREFQTYIRSMDKDFVAATIQAIGRCATNIGRVRDTCLNGLVQLLSNRDELVVAESVV-V 469

  Fly   425 IITIIEENADAKESGLSHLCEFIED-----------------CEHV-SLAVRILHLLGKEGPFAA 471
            |..:::.........:.||.:..::                 |||| .:|..:|..:.|.  |.|
  Rat   470 IKKLLQMQPAQHGEIIKHLAKLTDNIQVPMARASILWLIGEYCEHVPKIAPDVLRKMAKS--FTA 532

  Fly   472 TPSKYIRFIYNRVILESPIVRAAAVTAMAQF---GASCPALLSNILVLLGRCQMDPDDEVRDRAT 533
                           |..||:...:...|:.   .:....||:..::.|.:  .|.:.::||||.
  Rat   533 ---------------EEDIVKLQVINLAAKLYLTNSKQTKLLTQYVLSLAK--YDQNYDIRDRAR 580

  Fly   534 Y 534
            :
  Rat   581 F 581

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gammaCOP	NP_001263145.1	SEC21	11..877	CDD:227565	113/586 (19%)
		HEAT repeat	402..427	CDD:293787	7/24 (29%)
		HEAT repeat	439..465	CDD:293787	8/43 (19%)
		HEAT repeat	475..505	CDD:293787	4/32 (13%)
		HEAT repeat	512..538	CDD:293787	6/23 (26%)
		COP-gamma_platf	620..761	CDD:285908
		Coatomer_g_Cpla	763..877	CDD:292991
Ap3b2	NP_001101002.2	Adaptin_N	34..590	CDD:366724	113/586 (19%)
		HEAT repeat	111..139	CDD:293787	9/27 (33%)
		HEAT repeat	145..173	CDD:293787	5/27 (19%)
		HEAT repeat	182..208	CDD:293787	6/25 (24%)
		AP3B1_C	804..947	CDD:373301

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910