DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gammaCOP and COPG2

DIOPT Version :9

Sequence 1:	NP_001263145.1	Gene:	gammaCOP / 43717	FlyBaseID:	FBgn0028968	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	NP_036265.3	Gene:	COPG2 / 26958	HGNCID:	2237	Length:	871	Species:	Homo sapiens

Alignment Length:	876	Identity:	521/876 - (59%)
Similarity:	668/876 - (76%)	Gaps:	14/876 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 EKDDEEDGP-SNAYQNLEKTSVLQETRTFNETPVNPRKCIHILTKILYLINQGEQLVAREATDCF 70
            :|.|||.|. ||.:|:|||::||||.|.|||||:|||:|:|||||||||:||||.....|||:.|
Human     6 DKKDEESGSGSNPFQHLEKSAVLQEARIFNETPINPRRCLHILTKILYLLNQGEHFGTTEATEAF 70

  Fly    71 FAMTKLFQSKDVVLRRMVYLGIKELSSIAEDVIIVTSSLTKDMTGKEDLYRAAAIRALCSITDNT 135
            ||||:||||.|..||||.||.|||:::|:|||||||||||||||||||:||..||||||.|||.|
Human    71 FAMTRLFQSNDQTLRRMCYLTIKEMATISEDVIIVTSSLTKDMTGKEDVYRGPAIRALCRITDGT 135

  Fly   136 MLQAVERYMKQCIVDKNAAVSCAALVSSLRLANTAGDVVKRWANEAQEALNSDNIMVQYHALGLL 200
            ||||:||||||.||||.::||.:||||||.:...:.||||||.||||||.:||||||||||||:|
Human   136 MLQAIERYMKQAIVDKVSSVSSSALVSSLHMMKISYDVVKRWINEAQEAASSDNIMVQYHALGVL 200

  Fly   201 YHIRKSDRLAVSKLVNKLTRGSLKSPYAVCMLIRIACKLIEEEDIPSEELSDSPLFTFIESCLRH 265
            ||:||:|||||||::||.|:..|||.:|.|||||||.:|::|    :|:..:||||.|||||||:
Human   201 YHLRKNDRLAVSKMLNKFTKSGLKSQFAYCMLIRIASRLLKE----TEDGHESPLFDFIESCLRN 261

  Fly   266 KSEMVIYEAAHAIVNLKNTNPRMLSPAFSILQLFCSSPKATLRFAAVRTLNKVAMTHPAAVTTCN 330
            |.||||||||.||::|.|...|.|:||.|:|||||||||..||:|||||||||||.||:|||.||
Human   262 KHEMVIYEAASAIIHLPNCTARELAPAVSVLQLFCSSPKPALRYAAVRTLNKVAMKHPSAVTACN 326

  Fly   331 LDLEGLITDSNRSVATLAITTLLKTGAESSVERLMKQISTFVAEISDEFKVVVVQAICALCTKYP 395
            ||||.||||||||:||||||||||||:||||:|||||||:||:||||||||||||||.|||.|||
Human   327 LDLENLITDSNRSIATLAITTLLKTGSESSVDRLMKQISSFVSEISDEFKVVVVQAISALCQKYP 391

  Fly   396 RKHTVLMNFLSGMLREEGGLEYKTSIVDTIITIIEENADAKESGLSHLCEFIEDCEHVSLAVRIL 460
            |||:|:|.|||.|||::||.|||.:|||.||:|:|||.::||:||:|||||||||||..||.:||
Human   392 RKHSVMMTFLSNMLRDDGGFEYKRAIVDCIISIVEENPESKEAGLAHLCEFIEDCEHTVLATKIL 456

  Fly   461 HLLGKEGPFAATPSKYIRFIYNRVILESPIVRAAAVTAMAQFGASCPALLSNILVLLGRCQMDPD 525
            ||||||||....||||||||:|||:||:..||||||:|:|:|||...:||.:|||||.||.||.|
Human   457 HLLGKEGPRTPVPSKYIRFIFNRVVLENEAVRAAAVSALAKFGAQNESLLPSILVLLQRCMMDTD 521

  Fly   526 DEVRDRATYYLSILNSERPELYKNYIIERENCSLALLEKSLVEHLNGDVDTRFDISIVPKAAIVK 590
            ||||||||:||::|...:..|...||......|:..:||:|.::.....:..||:..:|.|  :.
Human   522 DEVRDRATFYLNVLQQRQMALNATYIFNGLTVSVPGMEKALHQYTLEPSEKPFDMKSIPLA--MA 584

  Fly   591 PVIANDVMLVTSSAPRPPKI--TREEESAARLAQLPGIQVLGPIHRSTAPIQLTESETEYTVQCI 653
            ||...... :|..|.:|.|:  :|::....:||.:|....:||:.:|:.|:||||:||||.|:||
Human   585 PVFEQKAE-ITLVATKPEKLAPSRQDIFQEQLAAIPEFLNIGPLFKSSEPVQLTEAETEYFVRCI 648

  Fly   654 KHIFGQHVVFQFDCLNTLSDQILENVRVELTLPEGFTTRAVIPCPKLPYNDLQTTFVIVEFPPDA 718
            ||:|..|:||||||.|||:||:||.|.|::...:.:...:.||.|.||||.....:.:|..|.|.
Human   649 KHMFTNHIVFQFDCTNTLNDQLLEKVTVQMEPSDSYEVLSCIPAPSLPYNQPGICYTLVRLPDDD 713

  Fly   719 ANSIA-TFGATLRFVVKDCDPNTGEPESEEGYDDEYMLEDLELTVADQIQKTRKNNFQVSWDAAD 782
            ..::| :|..|::|.|:|||||||.|: |:||||||:|||||:||:|.|||..|.||..:|:  :
Human   714 PTAVAGSFSCTMKFTVRDCDPNTGVPD-EDGYDDEYVLEDLEVTVSDHIQKVLKPNFAAAWE--E 775

  Fly   783 SEEWLQAEDTFVLSAVTTLQDAVNTIVKILGLGAANLSENVPEGTHLHTLLCSGTFRGGAEILVR 847
            ..:..:.|:||.||:..||::|||.|:..||:.....|:.|||..:.|:|..:|.||||.::|||
Human   776 VGDTFEKEETFALSSTKTLEEAVNNIITFLGMQPCERSDKVPENKNSHSLYLAGIFRGGYDLLVR 840

  Fly   848 AKLALSEGVTLNLTVRSTDQDVAELITAAIG 878
            ::|||::|||:.:||||.::...::|.|::|
Human   841 SRLALADGVTMQVTVRSKERTPVDVILASVG 871

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gammaCOP	NP_001263145.1	SEC21	11..877	CDD:227565	518/869 (60%)
		HEAT repeat	402..427	CDD:293787	16/24 (67%)
		HEAT repeat	439..465	CDD:293787	20/25 (80%)
		HEAT repeat	475..505	CDD:293787	21/29 (72%)
		HEAT repeat	512..538	CDD:293787	20/25 (80%)
		COP-gamma_platf	620..761	CDD:285908	72/141 (51%)
		Coatomer_g_Cpla	763..877	CDD:292991	47/113 (42%)
COPG2	NP_036265.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21		7/14 (50%)
		SEC21	7..866	CDD:227565	518/868 (60%)
		HEAT 1	64..101		23/36 (64%)
		HEAT 2	283..320		28/36 (78%)
		HEAT repeat	288..313	CDD:293787	19/24 (79%)
		HEAT 3	321..355		29/33 (88%)
		HEAT repeat	323..354	CDD:293787	27/30 (90%)
		HEAT 4	356..392		30/35 (86%)
		HEAT repeat	363..385	CDD:293787	19/21 (90%)
		HEAT 5	395..430		22/34 (65%)
		HEAT repeat	398..423	CDD:293787	16/24 (67%)
		HEAT repeat	435..461	CDD:293787	20/25 (80%)
		HEAT 6	467..504		24/36 (67%)
		HEAT repeat	471..501	CDD:293787	21/29 (72%)
		HEAT repeat	508..534	CDD:293787	20/25 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145440
Domainoid	1	1.000	734	1.000	Domainoid score	I102
eggNOG	1	0.900	-	-		E1_COG5240
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56292
Inparanoid	1	1.050	1008	1.000	Inparanoid score	I286
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53896
OrthoDB	1	1.010	-	-		D207992at33208
OrthoFinder	1	1.000	-	-		FOG0002163
OrthoInspector	1	1.000	-	-		otm40884
orthoMCL	1	0.900	-	-		OOG6_101348
Panther	1	1.100	-	-	LDO	PTHR10261
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R230
SonicParanoid	1	1.000	-	-		X1625
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	15	14.840