DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gammaCOP and apl1

DIOPT Version :9

Sequence 1:	NP_001263145.1	Gene:	gammaCOP / 43717	FlyBaseID:	FBgn0028968	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	NP_596435.1	Gene:	apl1 / 2540375	PomBaseID:	SPBC2G2.06c	Length:	677	Species:	Schizosaccharomyces pombe

Alignment Length:	614	Identity:	128/614 - (20%)
Similarity:	235/614 - (38%)	Gaps:	126/614 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 KCIHILTKILYLINQGEQLVAREATDCFFAMTKLFQSKDVVLRRMVYLGIKELSSI-AEDVIIVT 106
            |.|..|.|.:..|:.|..:     :..|.::....:|.::.|:::.||.:|..:|: ..:.....
pombe    30 KRISALKKAIAGISYGYDM-----SSLFPSVISSMESNNLELKKLCYLYLKIYASVKPTEAKRAV 89

  Fly   107 SSLTKDMTGKEDLYRAAAIRALCSIT-DNTMLQAVERYMK-----QCIVDKNAAVSCAALVS-SL 164
            ..:..|:.....:.|:.|:|.|.|:. .|..:.|::..::     ...|.|.||:..|.|.| ..
pombe    90 KLILNDIYSSNPMIRSLALRTLTSVNIKNFWVAAMDPIVRLLDDTDPYVRKTAAIGIAKLYSYDK 154

  Fly   165 RLANTAGDVVKRWANEAQEALNSDNIMVQYHALGLLYHIRKS--------DRLAVSKLVNKLT-- 219
            ::..::|.:     :..:|.|:.::.:|..::|..|.:|..|        .|...:|||..||
pombe   155 KMVESSGLI-----DHLKEMLSDESSVVVANSLAALMNIVNSSTGFKLTFSREISNKLVKSLTDC 214

  Fly   220 -------------------RGSLK------SPY------AVCM----LIRIACKLIEEEDIPSEE 249
                               .|..:      ||:      ||||    :|......:::::...|.
pombe   215 SEWLQVAILDALIFYVPQKPGEAESFAERISPWLQHGNAAVCMGAVKVILYLTNYMKDDNRVKEY 279

  Fly   250 L--SDSPLFTFIESCLRHKSEMVIYEAAHAIVNLKNTNPRMLSPAFSILQLFCS-SPKATLRFAA 311
            .  :..||.|.    |..||....|.....|..:....|.|.  |..|...:|: .....::...
pombe   280 FMKTQPPLVTL----LARKSSATQYVILRNIQIILEQCPEMF--ANDIHFFYCNFDDPIYVKLEK 338

  Fly   312 VRTLNKVAMTH------PAAVT-TCNLDLEGLITDSNRSVATLAITTLLKTGAESSVERLMKQIS 369
            :..|.|:|..|      |..|. ...:|:| |:..|.:.:..|||.  ::......::.|::.::
pombe   339 LDILTKIADIHNLDQILPEFVEYASEIDVE-LVRKSVKCIGYLAIK--IEERKNDCIDSLIELMN 400

  Fly   370 TFVAEISDEFKVVVVQAICALCTKYPRKHTVLMNFLSGMLREEGGLEYKTSIVDTIITIIEENAD 434
            |.|..:..| .|:|::.|   ..|||..:..|:..|...|......:.|::    :|.|:.:.|:
pombe   401 TKVTYVIQE-AVIVIRDI---LRKYPGSYKSLVPILYENLDSLDEPDAKSA----VIWILGQYAE 457

  Fly   435 AKESGLSHLCEFIEDCEHVSLAVRILHLLGKEGPFAATPSKYIRFIYNRVILESPIVRAAAVTAM 499
            ..|..::.|.::::......|.:::..|..                ..:|.|:.|...|..||.:
pombe   458 EIEDSITLLNDYLKGFFDEPLEIQLTLLTA----------------VIKVFLKKPTAAADMVTNV 506

  Fly   500 AQFGASCPALLSNILVLLGRCQMDPDDEVRDRATYYLSILNSERPELYKNYIIER---ENCSLAL 561
            .|:   |...::           |||  :|||...|..:| |..|||.|..|:..   .|....:
pombe   507 LQW---CTDEVN-----------DPD--LRDRGIIYSRML-SANPELAKKVILANMPPVNVGTGM 554

  Fly   562 LEKSLVEHLNGDVDTRFDISIVPKAAIVK 590
            .:....|.|..::.|...|...|....||
pombe   555 YDPDTTEQLMLNISTLSSIYHKPPNRFVK 583

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gammaCOP	NP_001263145.1	SEC21	11..877	CDD:227565	128/614 (21%)
		HEAT repeat	402..427	CDD:293787	3/24 (13%)
		HEAT repeat	439..465	CDD:293787	3/25 (12%)
		HEAT repeat	475..505	CDD:293787	7/29 (24%)
		HEAT repeat	512..538	CDD:293787	7/25 (28%)
		COP-gamma_platf	620..761	CDD:285908
		Coatomer_g_Cpla	763..877	CDD:292991
apl1	NP_596435.1	COG5096	11..677	CDD:227427	128/614 (21%)
		HEAT repeat	11..34	CDD:293787	2/3 (67%)
		HEAT repeat	88..116	CDD:293787	6/27 (22%)
		Cnd1	100..266	CDD:289487	36/170 (21%)
		HEAT repeat	122..152	CDD:293787	7/29 (24%)
		HEAT repeat	161..187	CDD:293787	6/30 (20%)
		HEAT repeat	200..227	CDD:293787	6/26 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910