DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gammaCOP and copg-1

DIOPT Version :9

Sequence 1:	NP_001263145.1	Gene:	gammaCOP / 43717	FlyBaseID:	FBgn0028968	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	NP_001255464.1	Gene:	copg-1 / 177891	WormBaseID:	WBGene00011775	Length:	885	Species:	Caenorhabditis elegans

Alignment Length:	880	Identity:	482/880 - (54%)
Similarity:	635/880 - (72%)	Gaps:	17/880 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 RREKDDEEDGPSNAYQNLEKTSVLQETRTFNETPVNPRKCIHILTKILYLINQGEQLVAREATDC 69
            :..|.|||.| .|.|.:|:|||||||.|.|||||:|.|||..||:|::|:|.|||.:...|||:.
Worm    15 KTNKKDEETG-GNVYAHLDKTSVLQEARAFNETPINARKCCFILSKLIYIIQQGESIGRTEATEA 78

  Fly    70 FFAMTKLFQSKDVVLRRMVYLGIKELSSIAEDVIIVTSSLTKDMTGKEDLYRAAAIRALCSITDN 134
            ||.:|||:|||||.|||||||.:|||:.:::|||||||||||||||:|||||||||||||.|||.
Worm    79 FFGVTKLWQSKDVSLRRMVYLAVKELAEVSDDVIIVTSSLTKDMTGREDLYRAAAIRALCKITDT 143

  Fly   135 TMLQAVERYMKQCIVDKNAAVSCAALVSSLRLANTAGDVVKRWANEAQEALNSDNIMVQYHALGL 199
            .|||.:||||||.|||:|:|:|.:|:|||:.|...:.:||:|||||.|||::|||.|||||||.|
Worm   144 GMLQTIERYMKQAIVDRNSAISSSAIVSSIHLMRKSSEVVRRWANEVQEAVSSDNHMVQYHALAL 208

  Fly   200 LYHIRKSDRLAVSKLVNKLTRGSLKSPYAVCMLIRIACKLIEEEDIPSEELSDSPLFTFIESCLR 264
            ||.||.:|||||:|||.|.::.:|:||||||.|||||.:.:.::|   ....||.:|||||||||
Worm   209 LYQIRANDRLAVNKLVQKFSKNALRSPYAVCYLIRIATRCLVDDD---HCRPDSSVFTFIESCLR 270

  Fly   265 HKSEMVIYEAAHAIVNLKNTNPRMLSPAFSILQLFCSSPKATLRFAAVRTLNKVAMTHPAAVTTC 329
            ||||||:||||.|||:|..|.|..:.||.:.||:.|:||||.:|||||||||||||.||.||.:|
Worm   271 HKSEMVVYEAARAIVSLPQTTPSEIQPAITALQMCCTSPKAAVRFAAVRTLNKVAMAHPNAVMSC 335

  Fly   330 NLDLEGLITDSNRSVATLAITTLLKTGAESSVERLMKQISTFVAEISDEFKVVVVQAICALCTKY 394
            |:|||..|||.|||:|||||||||||||||||||||:||:.||.|||||||:|||.||.:||::|
Worm   336 NVDLEKFITDPNRSIATLAITTLLKTGAESSVERLMQQIAGFVNEISDEFKIVVVDAIRSLCSRY 400

  Fly   395 PRKHTVLMNFLSGMLREEGGLEYKTSIVDTIITIIEENADAKESGLSHLCEFIEDCEHVSLAVRI 459
            ||||||:|.||:.|||.:|..:||.:||:|||.|||||.|||.:||:|||||||||||.:|:.|:
Worm   401 PRKHTVMMPFLAKMLRSDGSYDYKKAIVETIIAIIEENPDAKVAGLAHLCEFIEDCEHDNLSTRV 465

  Fly   460 LHLLGKEGPFAATPSKYIRFIYNRVILESPIVRAAAVTAMAQFGASCPALLSNILVLLGRCQMDP 524
            |||||:|.|....||.|||||||||||||..||||||||:|:|||.|..|..:|.|||.||.:|.
Worm   466 LHLLGREAPKTPNPSSYIRFIYNRVILESTKVRAAAVTALAKFGAQCVDLRPSIQVLLKRCLLDS 530

  Fly   525 DDEVRDRATYYLSILNSERPELYKNYIIERENCSLALLEKSLVEHL-NGDVDTRFDISIVP--KA 586
            |||||||||:||.:|......|..|:|::....|.:.||:|::::| :|...:.||:.:||  :.
Worm   531 DDEVRDRATFYLKMLTEAAEGLIHNFILDGLQVSPSGLERSILDYLRSGSYSSPFDLRVVPVTQQ 595

  Fly   587 AIVKPVIANDVMLVTSSAPRPPKITREEESAARLAQLPGIQVLGPIHRSTAPIQLTESETEYTVQ 651
            |:.:|......::.....|:.||:   |..||:||.:|....|||:.:|:..|.||||..||||.
Worm   596 ALSQPEKRVPQLVEEEEKPKAPKV---EPYAAQLAAIPQFAALGPVFKSSTRIALTESIAEYTVH 657

  Fly   652 CIKHIFGQHVVFQFDCLNTLSDQILENVRVELTLPEG-FTTRAVIPCPKLPYNDLQTTFVIVEFP 715
            .|||.|...:|.||:|.||::||:|.:|.|||..|:| :.|...:...||||.::.:.|.::|||
Worm   658 MIKHTFANAMVLQFECKNTMNDQLLLDVSVELEDPDGEWETGNTVQIDKLPYGEVHSAFSLLEFP 722

  Fly   716 PDAANSIATFGATLRFVVKDCDPNTGEPESEEGYDDEYMLEDLELTVADQIQKTRKNNFQVSWDA 780
            ...|.| .:.||.|:|.|.|.||.:|||:|::.|:..|:||::::.|:|.:|...|::|..:|:|
Worm   723 DSGAIS-GSLGAILKFKVMDVDPTSGEPDSDDTYEQTYVLEEVDVNVSDSVQGVAKSSFGSAWEA 786

  Fly   781 ADSEEWLQAEDTFVLSAVTTLQDAVNTIVKILGLGAANLSENVPEGTHLHTLLCSGTFRGGAEIL 845
            ...:  ...|:||.||.|..:.|||..|.:||||.....|:.||||...||:..||.||||.::|
Worm   787 LGDD--ATREETFQLSTVENIPDAVKKISEILGLVPCERSDRVPEGKTQHTVFLSGVFRGGYDVL 849

  Fly   846 VRAKLAL---SEGVTLNLTVRSTDQDVAELITAAI 877
            .:|.:|:   ...:.:|:.::|.:..||:|:.:|:
Worm   850 SKATVAVDPNDNSIAMNIIIKSNEPLVADLVISAV 884

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gammaCOP	NP_001263145.1	SEC21	11..877	CDD:227565	479/872 (55%)
		HEAT repeat	402..427	CDD:293787	13/24 (54%)
		HEAT repeat	439..465	CDD:293787	19/25 (76%)
		HEAT repeat	475..505	CDD:293787	24/29 (83%)
		HEAT repeat	512..538	CDD:293787	18/25 (72%)
		COP-gamma_platf	620..761	CDD:285908	62/141 (44%)
		Coatomer_g_Cpla	763..877	CDD:292991	41/116 (35%)
copg-1	NP_001255464.1	SEC21	14..881	CDD:227565	481/875 (55%)
		HEAT repeat	298..328	CDD:293787	21/29 (72%)
		Nipped-B_C	305..>358	CDD:289591	39/52 (75%)
		HEAT repeat	338..364	CDD:293787	21/25 (84%)
		HEAT repeat	373..395	CDD:293787	16/21 (76%)
		HEAT repeat	408..433	CDD:293787	13/24 (54%)
		HEAT repeat	445..471	CDD:293787	19/25 (76%)
		HEAT repeat	481..511	CDD:293787	24/29 (83%)
		HEAT repeat	518..544	CDD:293787	18/25 (72%)
		HEAT repeat	550..576	CDD:293787	7/25 (28%)
		COP-gamma_platf	624..767	CDD:285908	63/143 (44%)
		Coatomer_g_Cpla	769..884	CDD:292991	41/116 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158558
Domainoid	1	1.000	685	1.000	Domainoid score	I60
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56292
Inparanoid	1	1.050	909	1.000	Inparanoid score	I184
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53896
OrthoDB	1	1.010	-	-		D207992at33208
OrthoFinder	1	1.000	-	-		FOG0002163
OrthoInspector	1	1.000	-	-		oto20216
orthoMCL	1	0.900	-	-		OOG6_101348
Panther	1	1.100	-	-	LDO	PTHR10261
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R230
SonicParanoid	1	1.000	-	-		X1625
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.940